Patent US5496804A successfully refreshed from Google Patents.
US5496804A
Expired / Lapsed
US
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Method for treating taxol side-effects with G-CSF
Assignee: United States Department of Health and Human Services
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Filing: 1994-11-21
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Granted: 1996-03-05
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Expires: 2014-11-21
Abstract
Abstract A method of treating a host using taxol comprising administering granulocyte colony-stimulating factor to the host being treated with taxol. The present inventive method allows for increased levels of taxol to be administered to the host in the treatment of various conditions, particularly with respect to ovarian tumors.
Inventors
- 👤 Eddie Reed
- 👤 Elise Kohn
- 👤 Gisele Sarosy
Bibliographic Details
Application Number
—
Jurisdiction
US
Data Source
google_patents
Last Synchronized
2026-11-07 12:53
CPC Classifications
A; A61; A61K; A61K38/00; A61K38/16; A61K38/17; A61K38/19; A61K38/193; A61P; A61P39/00
Claims Analysis
Total Claims: 16
Claim 1
Independent Claim
51 words
A method of treating a host being treated with taxol in an amount sufficient to cause a side effect selected from the group consisting of myelosupression, mucositis, and peripheral neuropathy, which method comprises administering to said host granulocyte colony-stimulating factor in an amount effective to alleviate or prevent said side effect.
Claim 2
Independent Claim
51 words
A method of treating a host being treated with taxol in an amount sufficient to cause a side effect selected from the group consisting of myelosupression, mucositis, and peripheral neuropathy, which method comprises administering to said host granulocyte colony-stimulating factor in an amount effective to alleviate or prevent said side effect.
Claim 3
Dependent Claim
24 words
The method of claim 1, wherein said host is being treated with taxol in an amount exceeding about 175 mg/m 2 / 21 days.
Claim 4
Dependent Claim
13 words
A method of claim 1, wherein said side effect is myelosuppression or mucositis.
Claim 5
Dependent Claim
21 words
The method of claim 3, wherein said granulocyte colony-stimulating factor is administered in an amount of at least about 5 μg/kg/day.
Claim 6
Dependent Claim
22 words
The method of claim 4, wherein said granulocyte colony-stimulating factor is administered in an amount of about 10 to about 20 μg/kg/day.
Claim 7
Dependent Claim
34 words
The method of claim 1, wherein said host is being treated with taxol once every three weeks and said granulocyte colony-stimulating factor is administered daily for at least seven days following the taxol treatment.
Claim 8
Dependent Claim
27 words
The method of claim 6 wherein said host is being treated with taxol in an amount of about 200 to about 250 mg/m 2 / 21 days.
Claim 9
Dependent Claim
18 words
The method of claim 1, wherein said host is being treated with taxol to treat a cancerous tumor.
Claim 10
Dependent Claim
16 words
The method of claim 8, wherein said cancerous tumor is a breast, lung or ovarian tumor.
Claim 11
Dependent Claim
13 words
The method of claim 9, wherein said cancerous tumor is an ovarian tumor.
Claim 12
Dependent Claim
24 words
The method of claim 10, wherein said host is being treated with taxol in an amount exceeding about 175 mg/m 2 / 21 days.
Claim 13
Dependent Claim
21 words
The method of claim 11, wherein said granulocyte colony-stimulating factor is administered in an amount of at least about 5 μg/kg/day.
Claim 14
Dependent Claim
22 words
The method of claim 12, wherein said granulocyte colony-stimulating factor is administered in an amount of about 10 to about 20 μg/kg/day.
Claim 15
Dependent Claim
34 words
The method of claim 13, wherein said host is being treated with taxol once every three weeks and said granulocyte colony-stimulating factor is administered daily for at least seven days following the taxol treatment.
Claim 16
Dependent Claim
27 words
The method of claim 14, wherein said host is being treated with taxol in an amount of about 200 to about 250 mg/m 2 / 21 days.
References Cited (Backward Citations)
USPTO Annuity & Maintenance Windows
| Annuity Stage | Window Opens | Payment Deadline | Surcharge Period Until | Estimated Fee | Status |
|---|---|---|---|---|---|
| 3.5 Years (Year 4) | 1999-03-05 | 1999-09-04 | 2000-03-05 | $2000.00 | Window Closed / Lapsed |
| 7.5 Years (Year 8) | 2003-03-05 | 2003-09-04 | 2004-03-05 | $3760.00 | Window Closed / Lapsed |
| 11.5 Years (Year 12) | 2007-03-05 | 2007-09-04 | 2008-03-05 | $7700.00 | Window Closed / Lapsed |