Patent US5485831A successfully refreshed from Google Patents.
US5485831A
Expired / Lapsed
US
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Pulse-injector for quantitative angiographic blood-flow measurements
Assignee: London Health Sciences Centre
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Filing: 1993-11-30
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Granted: 1996-01-23
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Expires: 2013-11-30
Abstract
Abstract A technique for pulsed-injection of radiographic contrast agent uses a pressurized source of contrast agent interrupted by a rotary valve at rates ranging from 1 to 30 Hz. This produces well-defined boli at the end of the catheter. The position of these boli is recorded by a digital radiographic system and analyzed to produce quantitative measurements of blood velocity and flow rate throughout the cardiac cycle.
Inventors
- 👤 David W. Holdsworth
- 👤 Maria Drangova
- 👤 Aaron Fenster
Bibliographic Details
Application Number
—
Jurisdiction
US
Data Source
google_patents
Last Synchronized
2026-10-24 14:22
CPC Classifications
A; A61; A61M; A61M5/00; A61M5/007
Claims Analysis
Total Claims: 37
Claim 1
Independent Claim
152 words
Injection apparatus for quantitative angiographic blood flow measurements by injection of a contrast agent into a fluid transporting vessel, said apparatus comprising a pressurized source of contrast agent, a catheter for conducting the contrast agent from the source into the vessel, a control valve to control flow of said agent between said source and said vessel, said control valve having an inlet port connected to said source, an outlet port connected to said catheter and a valve body within a housing and including a passageway to extend between said inlet and outlet port, said valve body being rotatable within said housing between an open position in which flow between said inlet and said outlet is permitted and a closed position in which flow between said inlet and said outlet is inhibited to connect and disconnect periodically said inlet port and said outlet port and thereby alternately allow and inhibit fluid flow therebetween.
Claim 2
Dependent Claim
152 words
Injection apparatus for quantitative angiographic blood flow measurements by injection of a contrast agent into a fluid transporting vessel, said apparatus comprising a pressurized source of contrast agent, a catheter for conducting the contrast agent from the source into the vessel, a control valve to control flow of said agent between said source and said vessel, said control valve having an inlet port connected to said source, an outlet port connected to said catheter and a valve body within a housing and including a passageway to extend between said inlet and outlet port, said valve body being rotatable within said housing between an open position in which flow between said inlet and said outlet is permitted and a closed position in which flow between said inlet and said outlet is inhibited to connect and disconnect periodically said inlet port and said outlet port and thereby alternately allow and inhibit fluid flow therebetween.
Claim 3
Dependent Claim
35 words
Injection apparatus according to claim 1 wherein said body includes a circumferential surface and said passageway includes a radial portion intersecting said surface and alignable with one of said ports during rotation of said body.
Claim 4
Dependent Claim
23 words
Injection apparatus according to claim 2 wherein said passageway includes an axial portion extending from said radial portion to another of said ports.
Claim 5
Dependent Claim
20 words
Injection apparatus according to claim 3 wherein said axial portion is located on the axis of rotation of said body.
Claim 6
Dependent Claim
16 words
Injection apparatus according to claim 4 wherein said axial portion is connected to said inlet port.
Claim 7
Dependent Claim
35 words
Injection apparatus according to claim 5 wherein said outlet port is located in a circumferential wall of said housing extending about said circumferential wall of said valve body and axially aligned with said radial portion.
Claim 8
Dependent Claim
20 words
Injection apparatus according to claim 1 wherein a drive motor is connected to said valve body to effect rotation thereof.
Claim 9
Dependent Claim
18 words
Injection apparatus according to claim 7 including a controller to vary the speed of rotation of said motor.
Claim 10
Dependent Claim
23 words
Injection apparatus according to claim 7 wherein said housing includes a cylindrical bore and said valve body is rotatably mounted in said bore.
Claim 11
Dependent Claim
24 words
Injection apparatus according to claim 9 wherein said bore includes an end wall and one of said ports is located in said end wall.
Claim 12
Dependent Claim
21 words
Injection apparatus according to claim 10 wherein said one port is located on the axis of rotation of said valve body.
Claim 13
Dependent Claim
20 words
Injection apparatus according to claim 10 wherein another of said ports is located in the circumferential wall of said bore.
Claim 14
Dependent Claim
28 words
Injection apparatus according to claim 12 wherein said passageway includes an axial portion aligned with said one port and a radial portion axially aligned with said other port.
Claim 15
Dependent Claim
43 words
Injection apparatus according to claim 13 wherein said radial portion of said passageway and said other port have respectively circular cross sections and flow between said inlet port and said outlet port is permitted upon said radial portion and said other port overlapping.
Claim 16
Dependent Claim
21 words
Injection apparatus according to claim 14 wherein said one port is located on the axis of rotation of said valve body.
Claim 17
Dependent Claim
14 words
Injection apparatus according to claim 15 wherein said one port is said inlet port.
Claim 18
Dependent Claim
29 words
Injection apparatus according to claim 9 wherein said bore includes a circumferential wall extending about said valve body and one of said ports is located in said circumferential wall.
Claim 19
Dependent Claim
31 words
Injection apparatus according to claim 17 wherein said passageway includes a radial portion extending to a circumferential wall of said body and axially aligned in said bore with said one port.
Claim 20
Dependent Claim
24 words
Injection apparatus according to claim 18 wherein said bore includes an end wall and another of said ports is located in said end wall.
Claim 21
Dependent Claim
30 words
Injection apparatus according to claim 19 wherein said passageway includes an axial portion extending from said radial portion to an end face of said body adjacent to said other port.
Claim 22
Dependent Claim
25 words
Injection apparatus according to claim 20 wherein said other port and said axial portion are located on the axis of rotation of said valve body.
Claim 23
Dependent Claim
37 words
Injection apparatus according to claim 19 wherein a bearing is located between said body and said housing at an opposite end of said bore to said end wall to support said body for rotation in said housing.
Claim 24
Dependent Claim
62 words
Injection apparatus according to claim 1 wherein said catheter includes a plurality of spaced apertures at its distal end to permit egress of said contrast agent from an internal duct of said catheter, said distal end being sealed and said apertures being spaced to reduce an initial extent of a bolus of contrast agent in said vessel and to reduce jetting thereof.
Claim 25
Dependent Claim
19 words
Injection apparatus according to claim 23 wherein said apertures are spaced apart along the longitudinal axis of said catheter.
Claim 26
Dependent Claim
12 words
Injection apparatus according to claim 24 wherein adjacent apertures are displaced circumferentially.
Claim 27
Dependent Claim
23 words
Injection apparatus according to claim 25 wherein said apertures provide a cumulative area greater than the cross sectional area of said internal duct.
Claim 28
Dependent Claim
21 words
Injection apparatus according to claim 26 wherein said apertures provide a cross sectional area three times that of said internal duct.
Claim 29
Dependent Claim
26 words
Injection apparatus according to claim 26 wherein said apertures are arranged as three axially spaced sets and each set includes a pair of diametrically opposed apertures.
Claim 30
Dependent Claim
21 words
Injection apparatus according to claim 28 wherein one of said sets is displaced circumferentially 90 degrees from the other two sets.
Claim 31
Dependent Claim
26 words
Injection apparatus according to claim 29 wherein said internal duct has an internal diameter of 1 mm and said apertures have a diameter of 0.7 mm.
Claim 32
Dependent Claim
128 words
A catheter for use with an injection apparatus to inject a contrast agent into a vessel, said catheter comprising an elongate body having an internal duct extending through said body and sealed at one end to inhibit flow therethrough, a plurality of apertures adjacent said one end of said body to allow egress of said agent from said duct, said apertures being axially spaced from one another along said body with adjacent apertures displaced circumferentially, said apertures being dimensioned to provide a cumulative area greater than the cross sectional area of said internal duct and being located within a 4.7 mm. axial extent of said body whereby an initial extent of a bolus of contrast agent along the vessel is reduced and jetting of the agent is avoided.
Claim 33
Dependent Claim
128 words
A catheter for use with an injection apparatus to inject a contrast agent into a vessel, said catheter comprising an elongate body having an internal duct extending through said body and sealed at one end to inhibit flow therethrough, a plurality of apertures adjacent said one end of said body to allow egress of said agent from said duct, said apertures being axially spaced from one another along said body with adjacent apertures displaced circumferentially, said apertures being dimensioned to provide a cumulative area greater than the cross sectional area of said internal duct and being located within a 4.7 mm. axial extent of said body whereby an initial extent of a bolus of contrast agent along the vessel is reduced and jetting of the agent is avoided.
Claim 34
Dependent Claim
21 words
A catheter according to claim 31 wherein said apertures provide a cross sectional area three times that of said internal duct.
Claim 35
Dependent Claim
26 words
A catheter according to claim 32 wherein said apertures are arranged as three axially spaced sets and each set includes a pair of diametrically opposed apertures.
Claim 36
Dependent Claim
21 words
A catheter according to claim 33 wherein one of said sets is displaced circumferentially 90 degrees from the other two sets.
Claim 37
Dependent Claim
26 words
A catheter according to claim 34 wherein said internal duct has an internal diameter of 1 mm. and said apertures have a diameter of 0.7 mm.
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USPTO Annuity & Maintenance Windows
| Annuity Stage | Window Opens | Payment Deadline | Surcharge Period Until | Estimated Fee | Status |
|---|---|---|---|---|---|
| 3.5 Years (Year 4) | 1999-01-22 | 1999-07-24 | 2000-01-23 | $2000.00 | Window Closed / Lapsed |
| 7.5 Years (Year 8) | 2003-01-22 | 2003-07-24 | 2004-01-23 | $3760.00 | Window Closed / Lapsed |
| 11.5 Years (Year 12) | 2007-01-22 | 2007-07-24 | 2008-01-23 | $7700.00 | Window Closed / Lapsed |