Patent BE524630A successfully refreshed from Google Patents.
US5480980A
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US
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7-Deaza-2'-deoxyguanosine nucleotides and nucleic acids analogs thereof
Assignee: Roche Diagnostics GmbH
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Filing: 1988-11-14
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Granted: 1996-01-02
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Expires: 2008-11-14
Abstract
Abstract The present invention provides 7-deaza-2'-deoxy-guanosine nucleotides of the general formula: <IMAGE> wherein R is a -PO3H2, -P2O6H3 or -P3O9H4 residue or an alkali metal, alkaline earth metal or ammonium salt of the phosphate groups. The present invention also provides processes for the preparation of these nucleotides and is also concerned with the use thereof in the sequencing of DNA.
Inventors
- 👤 Frank Seela
Bibliographic Details
Application Number
—
Jurisdiction
US
Data Source
google_patents
Last Synchronized
2026-11-06 14:49
CPC Classifications
C; C07; C07H; C07H19/00; C07H19/02; C07H19/04; C07H19/16; C07H19/20; C07H19/14
Claims Analysis
Total Claims: 14
Claim 1
Independent Claim
31 words
A compound of the formula ##STR4## wherein R is PO 3 H 2 , P 2 O 6 H 3 or an alkali metal, alkaline earth metal, or ammonium salt thereof.
Claim 2
Dependent Claim
31 words
A compound of the formula ##STR4## wherein R is PO 3 H 2 , P 2 O 6 H 3 or an alkali metal, alkaline earth metal, or ammonium salt thereof.
Claim 3
Dependent Claim
8 words
The compound of claim 1, designated 7-deaza-2'-deoxyguanosine 5'-diphosphate.
Claim 4
Dependent Claim
8 words
The compound of claim 1, designated 7-deaza-2'-deoxyguanosine 5'-monophosphate.
Claim 5
Dependent Claim
17 words
A desoxyribonucleic acid sequence comprising 7-deazaguanine as a nucleic base, wherein said base has the formula: ##STR5##
Claim 6
Dependent Claim
17 words
A desoxyribonucleic acid sequence comprising 7-deazaguanine as a nucleic base, wherein said base has the formula: ##STR5##
Claim 7
Dependent Claim
34 words
A nucleic acid sequence having a terminal nucleotide derived from a nucleotide of the formula: ##STR6## where R is PO 3 H 2 or an alkali metal, alkaline earth metal or ammonia salt thereof.
Claim 8
Dependent Claim
34 words
A nucleic acid sequence having a terminal nucleotide derived from a nucleotide of the formula: ##STR6## where R is PO 3 H 2 or an alkali metal, alkaline earth metal or ammonia salt thereof.
Claim 9
Dependent Claim
34 words
A nucleic acid sequence having incorporated therein at least one nucleotide of the formula ##STR7## wherein R is PO 3 H 2 , or an alkali metal, alkaline earth metal or ammonium salt thereof.
Claim 10
Dependent Claim
34 words
A nucleic acid sequence having incorporated therein at least one nucleotide of the formula ##STR7## wherein R is PO 3 H 2 , or an alkali metal, alkaline earth metal or ammonium salt thereof.
Claim 11
Dependent Claim
43 words
A nucleic acid sequence having a terminal nucleotide derived from a nucleotide of the formula: ##STR8## where R is P 2 O 6 H 3 or P 3 O 9 H 4 or an alkali metal, alkaline earth metal or ammonia salt thereof.
Claim 12
Dependent Claim
43 words
A nucleic acid sequence having a terminal nucleotide derived from a nucleotide of the formula: ##STR8## where R is P 2 O 6 H 3 or P 3 O 9 H 4 or an alkali metal, alkaline earth metal or ammonia salt thereof.
Claim 13
Dependent Claim
17 words
The nucleic acid sequence of claim 7 wherein R is P 3 O 9 H 4 .
Claim 14
Dependent Claim
17 words
The nucleic acid sequence of claim 7, wherein R is P 2 O 6 H 3 .
References Cited (Backward Citations)
USPTO Annuity & Maintenance Windows
| Annuity Stage | Window Opens | Payment Deadline | Surcharge Period Until | Estimated Fee | Status |
|---|---|---|---|---|---|
| 3.5 Years (Year 4) | 1999-01-01 | 1999-07-03 | 2000-01-02 | $2000.00 | Window Closed / Lapsed |
| 7.5 Years (Year 8) | 2003-01-01 | 2003-07-03 | 2004-01-02 | $3760.00 | Window Closed / Lapsed |
| 11.5 Years (Year 12) | 2007-01-01 | 2007-07-03 | 2008-01-02 | $7700.00 | Window Closed / Lapsed |