US5478745A
Expired / Lapsed
US
⏱️ 0.0 years remaining
Recombinant viral vector system
Assignee: University of Pittsburgh
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Filing: 1992-12-04
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Granted: 1995-12-26
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Expires: 2012-12-04
Abstract
Abstract The present invention relates to a system for replication and encapsidation of recombinant DNA fragments into virus particles comprised of adenovirus associated viral (AAV) capsid proteins. The invention provides a means of obtaining recombinant viral stocks that may be used to treat patients suffering from genetic diseases.
Inventors
- 👤 Richard J. Samulski
- 👤 Xiao Xiao
Bibliographic Details
Application Number
—
Jurisdiction
US
Data Source
google_patents
Last Synchronized
2026-11-03 23:13
CPC Classifications
C; C12; C12N; C12N15/00; C12N15/09; C12N15/63; C12N15/79; C12N15/85; C12N15/86; A; A61; A61K; A61K48/00; C12N2750/00; C12N2750/00011; C12N2750/14011; C12N2750/14111; C12N2750/14141; C12N2750/14143
Claims Analysis
Total Claims: 7
Claim 1
Independent Claim
20 words
A nucleic acid molecule comprising a 165 base pair nucleotide sequence as depicted in FIG. 9 (SEQ ID NO: 1).
Claim 2
Dependent Claim
20 words
A nucleic acid molecule comprising a 165 base pair nucleotide sequence as depicted in FIG. 9 (SEQ ID NO: 1).
Claim 3
Dependent Claim
30 words
A recombinant DNA vector comprising a DNA nucleotide sequence encoding a protein of interest and a 165 base pair nucleotide sequence as depicted in FIG. 9 (SEQ ID NO: 1).
Claim 4
Dependent Claim
30 words
A recombinant DNA vector comprising a DNA nucleotide sequence encoding a protein of interest and a 165 base pair nucleotide sequence as depicted in FIG. 9 (SEQ ID NO: 1).
Claim 5
Dependent Claim
22 words
The recombinant DNA vector according to claim 2 further comprising a DNA nucleotide sequence that encodes the AAV REP and CAP proteins.
Claim 6
Dependent Claim
29 words
The recombinant DNA vector according to claim 2 further comprising a DNA nucleotide sequence recognized by bacterial gamma delta resolvase as depicted in FIG. 10 (SEQ ID NO: 2).
Claim 7
Dependent Claim
29 words
The recombinant DNA vector according to claim 3 further comprising a DNA nucleotide sequence recognized by bacterial gamma delta resolvase as depicted in FIG. 10 (SEQ ID NO: 2).
References Cited (Backward Citations)
US4797368A
Cited
US5139941A
Cited
USPTO Annuity & Maintenance Windows
| Annuity Stage | Window Opens | Payment Deadline | Surcharge Period Until | Estimated Fee | Status |
|---|---|---|---|---|---|
| 3.5 Years (Year 4) | 1998-12-25 | 1999-06-26 | 1999-12-26 | $2000.00 | Window Closed / Lapsed |
| 7.5 Years (Year 8) | 2002-12-25 | 2003-06-26 | 2003-12-26 | $3760.00 | Window Closed / Lapsed |
| 11.5 Years (Year 12) | 2006-12-25 | 2007-06-26 | 2007-12-26 | $7700.00 | Window Closed / Lapsed |