US5476444A
Expired / Lapsed
US
⏱️ 0.0 years remaining
Specialized perfusion protocol for whole-body hyperthermia
Assignee: THERMASOLUTIONS
•
Filing: 1994-10-04
•
Granted: 1995-12-19
•
Expires: 2014-10-04
Abstract
Abstract A method for extracorporeal blood heating to effect whole body hyperthermia, which utilizes a hemodialyzer with a sorbent suspension in the dialysate, a blood pump and a heat exchanger--in addition to various probes and catheters and heated anterior and posterior blankets for the patient--to effect extracorporeal treatment without adverse effect on blood physiology and without the need for general anesthesia. Blood returning to the body is heated to at least about 46° C. Incorporation of hemodialysis into the blood heating treatment solves at once several problems which plagued prior art hyperthermia techniques: it rectifies any imbalances of sodium, potassium, magnesium, bicarbonate or phosphate, and may remove toxins incident to necrosis of tumors and virally infected cells. Hyperthermia protocols with sorbent--based dialysis of blood thus avoid the various serious side effects which complicated--even to the point of death--the hyperthermia treatments known from the past.
Inventors
- 👤 Norman G. Keeling
- 👤 Stephen R. Ash
- 👤 Robert B. Truitt
- 👤 Joseph A. Guzman
Bibliographic Details
Application Number
—
Jurisdiction
US
Data Source
google_patents
Last Synchronized
2026-10-26 22:48
CPC Classifications
A; A61; A61M; A61M1/00; A61M1/36; A61M1/369; A61F; A61F7/00; A61F7/0053; A61F7/02; A61F7/08; A61F7/12; A61M1/34; A61M1/3472; A61M1/3486; A61M1/3493; A61M1/3607; A61M1/3609; A61F2007/0054; A61F2007/0059; A61F2007/126; A61M1/14; A61M1/16; A61M1/1694; A61M1/1696; A61M2205/00; A61M2205/33; A61M2205/3368; A61M2205/36; A61M2205/366
Claims Analysis
Total Claims: 18
Claim 1
Independent Claim
112 words
A method for the extracorporeal heating of blood in a patient having veins and arteries for the flow of blood in which extracorporeal hyperthermia is indicated, comprising the steps of: creating an extracorporeal blood circuit; catheterizing one of said veins or said arteries; connecting said catheterizing vein or artery to said extracorporeal blood circuit, whereby blood flows from said vein or artery into said circuit; heating at least some of the blood in said extracorporeal blood circuit to a temperature of at least 46° C. by a primary heating means; subjecting at least some of the blood in said extracorporeal blood circuit to hemodialysis; and returning said heated blood to the patient.
Claim 2
Independent Claim
112 words
A method for the extracorporeal heating of blood in a patient having veins and arteries for the flow of blood in which extracorporeal hyperthermia is indicated, comprising the steps of: creating an extracorporeal blood circuit; catheterizing one of said veins or said arteries; connecting said catheterizing vein or artery to said extracorporeal blood circuit, whereby blood flows from said vein or artery into said circuit; heating at least some of the blood in said extracorporeal blood circuit to a temperature of at least 46° C. by a primary heating means; subjecting at least some of the blood in said extracorporeal blood circuit to hemodialysis; and returning said heated blood to the patient.
Claim 3
Dependent Claim
37 words
The method according to claim 1 wherein said heating step further comprises heating at least some of the blood in said extracorporeal blood circuit by elevating the temperature of a dialyzing solution used in the hemodialysis step.
Claim 4
Dependent Claim
37 words
The method according to claim 2 wherein said heating step further comprises heating at least some of the blood in said extracorporeal blood circuit by elevating the temperature of the blood directly with a heat exchanging means.
Claim 5
Dependent Claim
36 words
The method according to claim 1 wherein said heating step further comprises heating at least some of the blood in said extracorporeal blood circuit to raise the core temperature of the patient to approximately 41.5°-42° C.
Claim 6
Dependent Claim
15 words
The method according to claim 1 wherein said extracorporeal blood circuit includes a blood pump.
Claim 7
Dependent Claim
30 words
The method according to claim 5 wherein said blood pump is upstream of a means for effecting said hemodialysis, and including a supplemental heating means associated with said blood pump.
Claim 8
Dependent Claim
26 words
The method according to claim 6 wherein said hemodialysis is effected by means of a hemodialyzer containing at least one dialysis membrane and a sorbent suspension.
Claim 9
Dependent Claim
22 words
The method according to claim 7 wherein said heating step further includes heating the body of the patient with a heated mattress.
Claim 10
Dependent Claim
22 words
The method according to claim 8 wherein said heating step further includes heating the body of the patient with a heated blanket.
Claim 11
Dependent Claim
19 words
The method according to claim 9 wherein said extracorporeal blood circuit contains a heat exchanger downstream of said hemodialyzer.
Claim 12
Independent Claim
39 words
A method for treating a neoplasm in a patient, comprising the steps of heating and dialyzing the blood of said patient, wherein the blood of the patient is heated for a period of time to at least 46° C.
Claim 13
Independent Claim
39 words
A method for treating a neoplasm in a patient, comprising the steps of heating and dialyzing the blood of said patient, wherein the blood of the patient is heated for a period of time to at least 46° C.
Claim 14
Dependent Claim
21 words
The method according to claim 11 wherein said heating effects whole body hyperthermia to a core body temperature of 41.5°-42° C.
Claim 15
Dependent Claim
70 words
The method according to claim 12 wherein said dialyzing is accomplished by means of sorbent suspension containing a water suspension of 140 grams powdered activated charcoal; 22.1 grams Na 2 HPO 4 *7H 2 O; 12.2 grams CaCl 2 *2H 2 O; 100 grams cation exchange resin loaded with Na, Ca, Mg and K ions; 8.8 grams NaCl; 15.1 grams NaHCO 3 ; and 3 grams of a glycol derivative.
Claim 16
Independent Claim
40 words
A method for treating a viral infection in a patient, comprising the steps of heating and dialyzing the blood of said patient, wherein the blood of the patient is heated for a period of time to at least 46° C.
Claim 17
Independent Claim
40 words
A method for treating a viral infection in a patient, comprising the steps of heating and dialyzing the blood of said patient, wherein the blood of the patient is heated for a period of time to at least 46° C.
Claim 18
Dependent Claim
21 words
The method according to claim 14 wherein said heating effects whole body hyperthermia to a core body temperature of 41.5°-42° C.
References Cited (Backward Citations)
US2886771A
Cited
US3482575A
Cited
US4061141A
Cited
US4479798A
Cited
US4191182A
Cited
US4321918B1
Cited
US4321918A
Cited
US4322275A
Cited
US4381004A
Cited
US4563170A
Cited
US4540401A
Cited
US4576143A
Cited
US4692138A
Cited
US4787883A
Cited
US4808189A
Cited
US4950225A
Cited
USPTO Annuity & Maintenance Windows
| Annuity Stage | Window Opens | Payment Deadline | Surcharge Period Until | Estimated Fee | Status |
|---|---|---|---|---|---|
| 3.5 Years (Year 4) | 1998-12-18 | 1999-06-19 | 1999-12-19 | $2000.00 | Window Closed / Lapsed |
| 7.5 Years (Year 8) | 2002-12-18 | 2003-06-19 | 2003-12-19 | $3760.00 | Window Closed / Lapsed |
| 11.5 Years (Year 12) | 2006-12-18 | 2007-06-19 | 2007-12-19 | $7700.00 | Window Closed / Lapsed |