US4576143A
Expired / Lapsed
US
⏱️ 0.0 years remaining
Method of immune modification by means of extracorporeal irradiation of the blood
Assignee: Individual
•
Filing: 1984-10-05
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Granted: 1986-03-18
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Expires: 2004-10-05
Abstract
Abstract In order to modify the immune system in humans having symptoms of a disorder of the immune system characterized by the presence of lymphocytes not apparently activated such lymphocytes are deactivated by a limited and closely controlled extracorporeal irradiation of an intensity and duration sufficient to cause the symptoms to disappear.
Inventors
- 👤 William T. Clark, III
Bibliographic Details
Application Number
—
Jurisdiction
US
Data Source
google_patents
Last Synchronized
2026-10-23 12:23
CPC Classifications
A; A61; A61M; A61M1/00; A61M1/36; A61M1/3681
Claims Analysis
Total Claims: 4
Claim 1
Independent Claim
132 words
A method for immune modification in a human patient having symptoms of a disorder of the immune system characterized by the presence of lymphocytes which are not appropriately activated which comprises: deactivating those lymphocytes which are not appropriately activated by passing the patient's blood through an extracoporeal link, and irradiating it while in transit through the link with a transit dose to render the not appropriately activated lymphocytes inactive but less than that required to significantly diminish the patient's lymphocyte count, and continuing such irradiation until a different lymphocyte population emerges, which different lymphocyte population is characterized by lymphocytes which have not been inappropriately activated, said irradiation continuing until the symptoms of the disorder have subsided, and further continuing the aforesaid irradiation of the patient's blood if the symptoms of disorder reappear.
Claim 2
Independent Claim
132 words
A method for immune modification in a human patient having symptoms of a disorder of the immune system characterized by the presence of lymphocytes which are not appropriately activated which comprises: deactivating those lymphocytes which are not appropriately activated by passing the patient's blood through an extracoporeal link, and irradiating it while in transit through the link with a transit dose to render the not appropriately activated lymphocytes inactive but less than that required to significantly diminish the patient's lymphocyte count, and continuing such irradiation until a different lymphocyte population emerges, which different lymphocyte population is characterized by lymphocytes which have not been inappropriately activated, said irradiation continuing until the symptoms of the disorder have subsided, and further continuing the aforesaid irradiation of the patient's blood if the symptoms of disorder reappear.
Claim 3
Dependent Claim
18 words
A method of claim 1 wherein the total dose per treatment is between about 24.4R and about 93.3R.
Claim 4
Dependent Claim
14 words
A method of claim 1 wherein the general immunity of the patient is increased.
References Cited (Backward Citations)
USPTO Annuity & Maintenance Windows
| Annuity Stage | Window Opens | Payment Deadline | Surcharge Period Until | Estimated Fee | Status |
|---|---|---|---|---|---|
| 3.5 Years (Year 4) | 1989-03-17 | 1989-09-16 | 1990-03-18 | $2000.00 | Window Closed / Lapsed |
| 7.5 Years (Year 8) | 1993-03-17 | 1993-09-16 | 1994-03-18 | $3760.00 | Window Closed / Lapsed |
| 11.5 Years (Year 12) | 1997-03-17 | 1997-09-16 | 1998-03-18 | $7700.00 | Window Closed / Lapsed |