US5457191A
Expired / Lapsed
US
⏱️ 0.0 years remaining
3-deazapurines
Assignee: Ionis Pharmaceuticals Inc
•
Filing: 1993-03-05
•
Granted: 1995-10-10
•
Expires: 2013-03-05
Abstract
Abstract This invention relates to compounds based on the 3-deazapurines ring system and to methods for making such compounds. The invention also generally relates to the field of "antisense" agents, agents that are capable of specific hybridization with a nucleotide sequence of an RNA. The 3-deazapurine-containing compounds of this invention can be useful for modulating the activity of RNA when incorporated into oligonucleotides. Oligonucleotides and their analogs are used for a variety of therapeutic and diagnostic purposes, such as treating diseases, regulating gene expression in experimental systems, assaying for RNA and for RNA products through the employment of antisense interactions with such RNA, diagnosing diseases, modulating the production of proteins and cleaving RNA in site specific fashions.
Inventors
- 👤 P. Dan Cook
- 👤 Oscar L. Acevedo
- 👤 Robert S. Andrews
Bibliographic Details
Application Number
—
Jurisdiction
US
Data Source
google_patents
Last Synchronized
2026-11-05 04:49
CPC Classifications
C; C12; C12N; C12N15/00; C12N15/09; C12N15/11; C12N15/113; C12N15/1138; A; A61; A61K; A61K47/00; A61K47/50; A61K47/51; C07; C07H; C07H19/00; C07H19/02; C07H19/04; C07H19/06; C07H19/10; C07H19/16; C07H19/20; C07H21/00; C07H23/00; C07J; C07J43/00; C07J43/003; C12N15/1131; C12N15/1132; C12N15/1133; C12N15/1135; C12N15/1137; C12N9/00; C12N9/0004; C12N9/0069; C12Q; C12Q1/00; C12Q1/68; C12Y; C12Y113/00; C12Y113/11; C12Y113/11012; A61K38/00; A61K48/00; C12N2310/00; C12N2310/30; C12N2310/31; C12N2310/312; C12N2310/3125; C12N2310/315; C12N2310/318; C12N2310/32; C12N2310/321; C12N2310/322; C12N2310/33; C12N2310/333; C12N2310/336; C12N2310/35; C12N2310/352; C12N2310/3521; C12N2310/3523; C12N2310/3527; C12N2310/353; C12N2310/3531; C12N2310/3533
Claims Analysis
Total Claims: 29
Claim 1
Independent Claim
120 words
A compound having the formula: ##STR7## wherein G is C or N; R 1 is NH 2 , alkyl having from one to about 12 carbons, substituted alkyl having from one to about 12 carbons, alkenyl having from one to about 12 carbons, substituted alkenyl having from one to about 12 carbons, aralkyl having from about 6 to about 30 carbons, amino, R 2 is amino, alkyl having from one to about 12 carbons, substituted alkyl having from one to about 12 carbons, alkenyl having from one to about 12 carbons, substituted alkenyl having from one to about 12 carbons, aralkyl having from about 6 to about 30 carbons; and Y is H, a nitrogen protecting group, ribose or deoxyribose.
Claim 2
Dependent Claim
120 words
A compound having the formula: ##STR7## wherein G is C or N; R 1 is NH 2 , alkyl having from one to about 12 carbons, substituted alkyl having from one to about 12 carbons, alkenyl having from one to about 12 carbons, substituted alkenyl having from one to about 12 carbons, aralkyl having from about 6 to about 30 carbons, amino, R 2 is amino, alkyl having from one to about 12 carbons, substituted alkyl having from one to about 12 carbons, alkenyl having from one to about 12 carbons, substituted alkenyl having from one to about 12 carbons, aralkyl having from about 6 to about 30 carbons; and Y is H, a nitrogen protecting group, ribose or deoxyribose.
Claim 3
Dependent Claim
11 words
The compound of claim 1 wherein Y is ribose or deoxyribose.
Claim 4
Dependent Claim
10 words
The compound of claim 1 wherein R 2 is amino.
Claim 5
Dependent Claim
18 words
The compound of claim 1 wherein R 1 is alkyl having from one to about 12 carbon atoms.
Claim 6
Dependent Claim
18 words
The compound of claim 1 wherein R 1 is alkenyl having from two to about 12 carbon atoms.
Claim 7
Dependent Claim
19 words
The compound of claim 1 wherein R 1 is aralkyl having from about 6 to about 30 carbon atoms.
Claim 8
Dependent Claim
18 words
The compound of claim 2 wherein R 1 is alkyl having from one to about 12 carbon atoms.
Claim 9
Dependent Claim
18 words
The compound of claim 2 wherein R 1 is alkenyl having from two to about 12 carbon atoms.
Claim 10
Dependent Claim
19 words
The compound of claim 2 wherein R 1 is aralkyl having from about 6 to about 30 carbon atoms.
Claim 11
Dependent Claim
31 words
The compound of claim 1 wherein G is N; R 1 is alkyl having from one to about 12 Garbon atoms; R 2 is amino; and Y is ribose or deoxyribose.
Claim 12
Dependent Claim
31 words
The compound of claim 1 wherein G ie N; R 1 is alkenyl having from two to about 12 carbon atoms; R 2 is amino; and Y is ribose or deoxyribose.
Claim 13
Dependent Claim
32 words
The compound of claim 1 wherein G is N; R 1 is aralkyl having from about 6 to about 30 Garbon atoms; R 2 is amino; and Y is ribose or deoxyribose.
Claim 14
Dependent Claim
29 words
The compound of claim 1 wherein G is N; R 1 is 1-methyl octane, 1-propene, phenyl methyl, or napthylethyl; R 2 is amino; and Y is ribose or deoxyribose.
Claim 15
Dependent Claim
24 words
The compound of claim 1 wherein Y is ribose or deoxyribose, said ribose or deoxyribose having an activated phosphate group at the 3' position.
Claim 16
Dependent Claim
138 words
A compound having the formula: ##STR8## wherein G is C or N; R B is H, NH 2 , alkyl having from one to about 12 carbons, substituted alkyl having from one to about 12 carbons, alkenyl having from one to about 12 carbons, substituted alkenyl having from one to about 12 carbons, aralkyl having from about 6 to about 30 carbons, amino; R 4 is NH 2 , alkyl having from one to about 12 carbons, substituted alkyl having from one to about 12 carbons, alkenyl having from one to about 12 carbons, substituted alkenyl having from one to about 12 carbons, aralkyl having from about 6 to about 30 carbons, amino; and Y is H, a nitrogen protecting group, ribose or deoxyribose; provided that when R 3 is H, R 4 is not NH 2 .
Claim 17
Dependent Claim
138 words
A compound having the formula: ##STR8## wherein G is C or N; R B is H, NH 2 , alkyl having from one to about 12 carbons, substituted alkyl having from one to about 12 carbons, alkenyl having from one to about 12 carbons, substituted alkenyl having from one to about 12 carbons, aralkyl having from about 6 to about 30 carbons, amino; R 4 is NH 2 , alkyl having from one to about 12 carbons, substituted alkyl having from one to about 12 carbons, alkenyl having from one to about 12 carbons, substituted alkenyl having from one to about 12 carbons, aralkyl having from about 6 to about 30 carbons, amino; and Y is H, a nitrogen protecting group, ribose or deoxyribose; provided that when R 3 is H, R 4 is not NH 2 .
Claim 18
Dependent Claim
11 words
The compound of claim 15 wherein Y is ribose or deoxyribose.
Claim 19
Dependent Claim
18 words
The compound of claim 15 wherein R 3 is alkyl having from one to about 12 carbon atoms.
Claim 20
Dependent Claim
18 words
The compound of claim 15 wherein R 3 is alkenyl having from two to about 12 carbon atoms.
Claim 21
Dependent Claim
19 words
The compound of claim 15 wherein R 3 is aralkyl having from about 6 to about 30 carbon atoms.
Claim 22
Dependent Claim
18 words
The compound of claim 16 wherein R 3 is alkyl having from one to about 12 carbon atoms.
Claim 23
Dependent Claim
18 words
The compound of claim 16 wherein R 3 is alkenyl having from two to about 12 carbon atoms.
Claim 24
Dependent Claim
19 words
The compound of claim 16 wherein R 3 is aralkyl having up to about 6 to 30 carbon atoms.
Claim 25
Dependent Claim
33 words
The compound of claim 15 wherein G is N; R 3 is alkyl having from one to about 12 carbon atoms; R 4 is NH 2 ; and Y is ribose or deoxyribose.
Claim 26
Dependent Claim
33 words
The compound of claim 15 wherein G is N; R 3 is alkenyl having from two to about 12 carbon atoms; R 4 is NH 2 ; and Y is ribose or deoxyribose.
Claim 27
Dependent Claim
33 words
The compound of claim 15 wherein G is N; R 3 is aralkyl having from about 6 to about 30 carbon atoms; R 4 is NH 2; and Y is ribose or deoxyribose.
Claim 28
Dependent Claim
31 words
The compound of claim 1 wherein G is N; R 3 is 1-methyl octane, 1-propene, phenyl methyl, or napthylethyl; R 4 is NH 2 ; and Y is ribose or deoxyribose.
Claim 29
Dependent Claim
24 words
The compound of claim 15 wherein Y is ribose or deoxyribose, said ribose or deoxyribose having an activated phosphate group at the 3' position.
References Cited (Backward Citations)
USPTO Annuity & Maintenance Windows
| Annuity Stage | Window Opens | Payment Deadline | Surcharge Period Until | Estimated Fee | Status |
|---|---|---|---|---|---|
| 3.5 Years (Year 4) | 1998-10-09 | 1999-04-10 | 1999-10-10 | $2000.00 | Window Closed / Lapsed |
| 7.5 Years (Year 8) | 2002-10-09 | 2003-04-10 | 2003-10-10 | $3760.00 | Window Closed / Lapsed |
| 11.5 Years (Year 12) | 2006-10-09 | 2007-04-10 | 2007-10-10 | $7700.00 | Window Closed / Lapsed |