US5451350A
Expired / Lapsed
US
⏱️ 0.0 years remaining
Test carrier for the determination of an analyte as well as a process for its production
Assignee: Roche Diagnostics GmbH
•
Filing: 1993-05-28
•
Granted: 1995-09-19
•
Expires: 2013-05-28
Abstract
Abstract An analytical device determines the analytes in a liquid sample. This device includes a layer of flat material which has a sample application area and a detection area thereupon. The detection area includes a reagent for determining the analyte, and the absorbent sample application area and the absorbent detection area are disposed within a liquid impermeable boundary. The layer of flat material also includes an absorbent connector which is disposed such that the sample application area and the detection area are connected by the absorbent connector. The liquid impermeable boundary and the absorbent connector prevents liquid from being transported between the sample application area and the detection area, except through the absorbent connector.
Inventors
- 👤 Heinz Macho
- 👤 Rolf Lerch
- 👤 Herbert Harttig
- 👤 Volker Zimmer
Bibliographic Details
Application Number
—
Jurisdiction
US
Data Source
google_patents
Last Synchronized
2026-10-23 02:42
CPC Classifications
G; G01; G01N; G01N33/00; G01N33/48; G01N33/50; G01N33/52; G01N33/521; Y; Y10; Y10S; Y10S435/00; Y10S435/805; Y10S436/00; Y10S436/807; Y10S436/81
Claims Analysis
Total Claims: 97
Claim 1
Independent Claim
148 words
An analytical device for determining an analyte in a liquid sample, said analytical device comprising: a layer of flat material having at least one absorbent sample application area and at least one absorbent detection area, said at least one absorbent detection area having a reagent for determining the analyte, said absorbent sample application area and said absorbent detection area being disposed within a liquid impermeable boundary, said sample application area not containing all reagents necessary for analyte detection and determination, wherein said layer of flat material further comprising at least one absorbent connector, said absorbent connector being disposed such that said sample application area and said detection area are connected by said absorbent connector, wherein said liquid impermeable boundary and said absorbent connector prevent liquid from being transported between said at least one sample application area and said at least one detection area, except through said absorbent connector.
Claim 2
Dependent Claim
148 words
An analytical device for determining an analyte in a liquid sample, said analytical device comprising: a layer of flat material having at least one absorbent sample application area and at least one absorbent detection area, said at least one absorbent detection area having a reagent for determining the analyte, said absorbent sample application area and said absorbent detection area being disposed within a liquid impermeable boundary, said sample application area not containing all reagents necessary for analyte detection and determination, wherein said layer of flat material further comprising at least one absorbent connector, said absorbent connector being disposed such that said sample application area and said detection area are connected by said absorbent connector, wherein said liquid impermeable boundary and said absorbent connector prevent liquid from being transported between said at least one sample application area and said at least one detection area, except through said absorbent connector.
Claim 3
Dependent Claim
44 words
An analytical device as recited in claim 1, wherein said at least one absorbent detection area is a plurality of detection areas, each of said plurality of detection areas being connected to said sample application area by a corresponding plurality of said absorbent connectors.
Claim 4
Dependent Claim
23 words
An analytical device as recited in claim 2, wherein said at least one sample application area is a plurality of sample application areas.
Claim 5
Dependent Claim
41 words
An analytical device as recited in claim 1, wherein said layer of flat material is heat-meltable material wherein said liquid-impermeable boundaries comprise heat treated areas of said heat-meltable material, wherein the heat treatment reduces the absorbency of the heat treated areas.
Claim 6
Dependent Claim
37 words
An analytical device as recited in claim 1, wherein said liquid-impermeable boundary comprises a material which is not a same material as the layer of material comprising the absorbent sample application area and the absorbent detection area.
Claim 7
Dependent Claim
33 words
An analytical device as recited in claim 1, wherein a surface area of said at least one sample application area is larger than a surface area of said at least one detection area.
Claim 8
Dependent Claim
27 words
An analytical device as recited in claim 1, wherein the at least one sample application area and the at least one detection area comprise a fibrous material.
Claim 9
Dependent Claim
25 words
An analytical device as recited in claim 1, wherein said at least one sample application area, detection area, and absorbent connector comprise a porous material.
Claim 10
Dependent Claim
148 words
A process for manufacturing an analytical device for determining an analyte in a liquid sample, said process comprising the steps of: providing a layer of flat absorbent first material; forming at least one absorbent sample application area on said layer of flat first material, said sample application area not containing all reagents necessary for analyte detection and determination; forming at least one absorbent detection area on said layer of flat first material; forming at least one absorbent connector connecting said at least one sample application area and said at least one detection area, wherein said at least one sample application area, said at least one detection area, and said absorbent connector are disposed within a liquid impermeable boundary, said liquid impermeable boundary being formed during said forming steps, and wherein said at least one absorbent detection area includes a reagent for determining the analyte in a liquid sample.
Claim 11
Dependent Claim
148 words
A process for manufacturing an analytical device for determining an analyte in a liquid sample, said process comprising the steps of: providing a layer of flat absorbent first material; forming at least one absorbent sample application area on said layer of flat first material, said sample application area not containing all reagents necessary for analyte detection and determination; forming at least one absorbent detection area on said layer of flat first material; forming at least one absorbent connector connecting said at least one sample application area and said at least one detection area, wherein said at least one sample application area, said at least one detection area, and said absorbent connector are disposed within a liquid impermeable boundary, said liquid impermeable boundary being formed during said forming steps, and wherein said at least one absorbent detection area includes a reagent for determining the analyte in a liquid sample.
Claim 12
Dependent Claim
47 words
A process for manufacturing an analytical device as recited in claim 9, wherein said steps of forming said sample application area, forming said detection area, and forming said absorbent connector comprises heat treatment of portions of said layer of flat first material forming the liquid impermeable boundaries.
Claim 13
Dependent Claim
20 words
A process for manufacturing an analytical device as recited in claim 10, wherein said heat treatment is performed with ultrasound.
Claim 14
Dependent Claim
142 words
A process for manufacturing an analytical device for determining an analyte in a liquid sample, said process comprising the steps of: providing a layer of flat absorbent first material; forming at least one absorbent sample application area on said layer of flat first material forming at least one absorbent detection area on said layer of flat first material, wherein said first absorbent first material is heat-deformable; forming at least one absorbent connector connecting said at least one sample application area and said at least one detection area, wherein said at least one sample application area, said at least one detection area, and said absorbent connector are disposed within a liquid impermeable boundary, said liquid impermeable boundary being formed during said forming steps, and wherein said at least one absorbent detection area includes a reagent for determining the analyte in a liquid sample.
Claim 15
Dependent Claim
142 words
A process for manufacturing an analytical device for determining an analyte in a liquid sample, said process comprising the steps of: providing a layer of flat absorbent first material; forming at least one absorbent sample application area on said layer of flat first material forming at least one absorbent detection area on said layer of flat first material, wherein said first absorbent first material is heat-deformable; forming at least one absorbent connector connecting said at least one sample application area and said at least one detection area, wherein said at least one sample application area, said at least one detection area, and said absorbent connector are disposed within a liquid impermeable boundary, said liquid impermeable boundary being formed during said forming steps, and wherein said at least one absorbent detection area includes a reagent for determining the analyte in a liquid sample.
Claim 16
Dependent Claim
80 words
A process for manufacturing an analytical device as recited in claim 9, further comprising the steps of: providing a heat-deformable second material; locating said heat-deformable second material under said layer of flat first material, wherein said steps of forming the sample application area, forming the detection area, and forming the absorbent connector are performed by heat-treatment of the heat-deformable second material such that the absorbent flat first material is affected in selected areas so that it is no longer absorbent.
Claim 17
Dependent Claim
177 words
A process for manufacturing an analytical device for determining an analyte in a liquid sample, said process comprising the steps of: providing a layer of flat absorbent first material; forming at least one absorbent sample application area on said layer of flat first material forming at least one absorbent detection area on said layer of flat first material; forming at least one absorbent connector connecting said at least one sample application area and said at least one detection area, providing a die having a plurality of elevations and depressions formed therein, wherein said steps of forming the sample application area, forming the detection area, and forming the absorbent connector is performed by contacting the layer of flat first material with said die; wherein said at least one sample application area, said at least one detection area, and said absorbent connector are disposed within a liquid impermeable boundary, said liquid impermeable boundary being formed during said forming steps, and wherein said at least one absorbent detection area includes a reagent for determining the analyte in a liquid sample.
Claim 18
Dependent Claim
177 words
A process for manufacturing an analytical device for determining an analyte in a liquid sample, said process comprising the steps of: providing a layer of flat absorbent first material; forming at least one absorbent sample application area on said layer of flat first material forming at least one absorbent detection area on said layer of flat first material; forming at least one absorbent connector connecting said at least one sample application area and said at least one detection area, providing a die having a plurality of elevations and depressions formed therein, wherein said steps of forming the sample application area, forming the detection area, and forming the absorbent connector is performed by contacting the layer of flat first material with said die; wherein said at least one sample application area, said at least one detection area, and said absorbent connector are disposed within a liquid impermeable boundary, said liquid impermeable boundary being formed during said forming steps, and wherein said at least one absorbent detection area includes a reagent for determining the analyte in a liquid sample.
Claim 19
Dependent Claim
25 words
A process for manufacturing an analytical device as recited in claim 14, wherein an outer surface of said die is coated with a non-stick material.
Claim 20
Dependent Claim
18 words
A process for manufacturing an analytical device as recited in claim 15, wherein said non-stick material comprises Teflon™.
Claim 21
Dependent Claim
20 words
An analytical device as recited in claim 1, wherein said layer of flat material has a consistent chemical make-up throughout.
Claim 22
Dependent Claim
162 words
An analytical device for determining an analyte in a liquid sample, said analytical device comprising: a layer of flat material having at least one absorbent sample application area and at least one absorbent detection area, said at least one absorbent detection area having a reagent for determining the analyte, said absorbent sample application area and said absorbent detection area being disposed within a liquid impermeable boundary, wherein said layer of flat material further comprising at least one absorbent connector, said absorbent connector being disposed such that said sample application area and said detection area are connected by said absorbent connector, wherein said liquid impermeable boundary and said absorbent connector prevent liquid from being transported between said at least one sample application area and said at least one detection area, except through said absorbent connector, and wherein said sample application area, said absorbent connector, said detection area, and said liquid impermeable boundary of said layer of flat material comprise the same chemical elements.
Claim 23
Dependent Claim
162 words
An analytical device for determining an analyte in a liquid sample, said analytical device comprising: a layer of flat material having at least one absorbent sample application area and at least one absorbent detection area, said at least one absorbent detection area having a reagent for determining the analyte, said absorbent sample application area and said absorbent detection area being disposed within a liquid impermeable boundary, wherein said layer of flat material further comprising at least one absorbent connector, said absorbent connector being disposed such that said sample application area and said detection area are connected by said absorbent connector, wherein said liquid impermeable boundary and said absorbent connector prevent liquid from being transported between said at least one sample application area and said at least one detection area, except through said absorbent connector, and wherein said sample application area, said absorbent connector, said detection area, and said liquid impermeable boundary of said layer of flat material comprise the same chemical elements.
Claim 24
Dependent Claim
29 words
An analytical device as recited in claim 1, wherein said sample application area and said detection area are located on a same surface of said layer of flat material.
Claim 25
Dependent Claim
49 words
An analytical device as recited in claim 1, wherein said layer of flat material comprises a combination of heat-meltable and non-heat-meltable material, wherein said liquid impermeable boundaries comprise heat treated areas of said combination of heat-meltable and non-heat meltable material, wherein heat treatment reduces absorbance of the heat-treated areas.
Claim 26
Dependent Claim
161 words
An analytical device for determining an analyte in a liquid sample, said analytical device comprising: a layer of flat material having at least one absorbent sample application area and at least one absorbent detection area, said at least one absorbent detection area having a reagent for determining the analyte, said absorbent sample application area and said absorbent detection area being disposed within a liquid impermeable boundary, wherein said layer of flat material further comprising at least one absorbent connector, said absorbent connector being disposed such that said sample application area and said detection area are connected by said absorbent connector, said at least one absorbent connector having a cross-section which is less than a cross-section of the sample application area and a cross-section of the detection area, wherein said liquid impermeable boundary and said absorbent connector prevent liquid from being transported between said at least one sample application area and said at least one detection area, except through said absorbent connector.
Claim 27
Dependent Claim
161 words
An analytical device for determining an analyte in a liquid sample, said analytical device comprising: a layer of flat material having at least one absorbent sample application area and at least one absorbent detection area, said at least one absorbent detection area having a reagent for determining the analyte, said absorbent sample application area and said absorbent detection area being disposed within a liquid impermeable boundary, wherein said layer of flat material further comprising at least one absorbent connector, said absorbent connector being disposed such that said sample application area and said detection area are connected by said absorbent connector, said at least one absorbent connector having a cross-section which is less than a cross-section of the sample application area and a cross-section of the detection area, wherein said liquid impermeable boundary and said absorbent connector prevent liquid from being transported between said at least one sample application area and said at least one detection area, except through said absorbent connector.
Claim 28
Dependent Claim
43 words
An analytical device as recited in claim 21, wherein said at least one detection area is a plurality of detection areas, each of said plurality of detection areas being connected to said sample application area by a corresponding plurality of said absorbent connectors.
Claim 29
Dependent Claim
23 words
An analytical device as recited in claim 22, wherein said at least one sample application area is a plurality of sample application areas.
Claim 30
Dependent Claim
41 words
An analytical device as recited in claim 21, wherein said layer of flat material is heat-meltable material wherein said liquid-impermeable boundaries comprise heat treated areas of said heat-meltable material, wherein the heat treatment reduces the absorbency of the heat treated areas.
Claim 31
Dependent Claim
48 words
An analytical device as recited in claim 21, wherein said layer of flat material comprises a combination of heat-meltable and non-heat-meltable material, wherein said liquid impermeable boundaries comprise heat treated areas of said combination of heat-meltable and non-heat-meltable material, wherein heat treatment reduces absorbance of the heat-treated areas.
Claim 32
Dependent Claim
37 words
An analytical device as recited in claim 21, wherein said liquid-impermeable boundary comprises a material which is not a same material as the layer of material comprising the absorbent sample application area and the absorbent detection area.
Claim 33
Dependent Claim
33 words
An analytical device as recited in claim 21, wherein a surface area of said at least one sample application area is larger than a surface area of said at least one detection area.
Claim 34
Dependent Claim
27 words
An analytical device as recited in claim 21, wherein the at least one sample application area and the at least one detection area comprise a fibrous material.
Claim 35
Dependent Claim
24 words
An analytical device as recited in claim 21, wherein at least one sample application area, detection area, and absorbent connector comprise a porous material.
Claim 36
Dependent Claim
20 words
An analytical device as recited in claim 21, wherein said layer of flat material has a consistent chemical make-up throughout.
Claim 37
Dependent Claim
29 words
An analytical device as recited in claim 21, wherein said sample application area and said detection area are located on a same surface of said layer of flat material.
Claim 38
Dependent Claim
166 words
An analytical device for determining an analyte in a liquid sample, said analytical device comprising: a layer of flat material having at least one absorbent sample application area and at least one absorbent detection area, said at least one absorbent detection area having a reagent for determining the analyte, said absorbent sample application area and said absorbent detection area being disposed within a liquid impermeable boundary, said layer of flat material being heat-meltable material, wherein the liquid-impermeable boundaries comprise heat treated areas of said heat-meltable material, wherein the heat treatment reduces the absorbency of the heat treated areas, wherein said layer of flat material further comprising at least one absorbent connector, said absorbent connector being disposed such that said sample application area and said detection area are connected by said absorbent connector, wherein said liquid impermeable boundary and said absorbent connector prevent liquid from being transported between said at least one sample application area and said at least one detection area, except through said absorbent connector.
Claim 39
Dependent Claim
166 words
An analytical device for determining an analyte in a liquid sample, said analytical device comprising: a layer of flat material having at least one absorbent sample application area and at least one absorbent detection area, said at least one absorbent detection area having a reagent for determining the analyte, said absorbent sample application area and said absorbent detection area being disposed within a liquid impermeable boundary, said layer of flat material being heat-meltable material, wherein the liquid-impermeable boundaries comprise heat treated areas of said heat-meltable material, wherein the heat treatment reduces the absorbency of the heat treated areas, wherein said layer of flat material further comprising at least one absorbent connector, said absorbent connector being disposed such that said sample application area and said detection area are connected by said absorbent connector, wherein said liquid impermeable boundary and said absorbent connector prevent liquid from being transported between said at least one sample application area and said at least one detection area, except through said absorbent connector.
Claim 40
Dependent Claim
43 words
An analytical device as recited in claim 32, wherein said at least one detection area is a plurality of detection areas, each of said plurality of detection areas being connected to said sample application area by a corresponding plurality of said absorbent connectors.
Claim 41
Dependent Claim
23 words
An analytical device as recited in claim 33, wherein said at least one sample application area is a plurality of sample application areas.
Claim 42
Dependent Claim
37 words
An analytical device as recited in claim 32, wherein said liquid-impermeable boundary comprises a material which is not a same material as the layer of material comprising the absorbent sample application area and the absorbent detection area.
Claim 43
Dependent Claim
33 words
An analytical device as recited in claim 32, wherein a surface area of said at least one sample application area is larger than a surface area of said at least one detection area.
Claim 44
Dependent Claim
27 words
An analytical device as recited in claim 32, wherein the at least one sample application area and the at least one detection area comprise a fibrous material.
Claim 45
Dependent Claim
24 words
An analytical device as recited in claim 32, wherein at least one sample application area, detection area, and absorbent connector comprise a porous material.
Claim 46
Dependent Claim
20 words
An analytical device as recited in claim 32, wherein said layer of flat material has a consistent chemical make-up throughout.
Claim 47
Dependent Claim
29 words
An analytical device as recited in claim 32, wherein said sample application area and said detection area are located on a same surface of said layer of flat material.
Claim 48
Dependent Claim
177 words
An analytical device for determining an analyte in a liquid sample, said analytical device comprising: a layer of flat material having at least one absorbent sample application area and at least one absorbent detection area, said at least one absorbent detection area having a reagent for determining the analyte, said absorbent sample application area and said absorbent detection area being disposed within a liquid impermeable boundary, said layer of flat material being formed of a mixture of heat-meltable and non-heat-meltable material, wherein said liquid impermeable boundary comprises heat treated areas of said mixture of heat-meltable and non-heat-meltable material, wherein the heat treatment reduces absorbance of the heat treated areas, wherein said layer of flat material further comprising at least one absorbent connector, said absorbent connector being disposed such that said sample application area and said detection area are connected by said absorbent connector, wherein said liquid impermeable boundary and said absorbent connector prevent liquid from being transported between said at least one sample application area and said at least one detection area, except through said absorbent connector.
Claim 49
Dependent Claim
177 words
An analytical device for determining an analyte in a liquid sample, said analytical device comprising: a layer of flat material having at least one absorbent sample application area and at least one absorbent detection area, said at least one absorbent detection area having a reagent for determining the analyte, said absorbent sample application area and said absorbent detection area being disposed within a liquid impermeable boundary, said layer of flat material being formed of a mixture of heat-meltable and non-heat-meltable material, wherein said liquid impermeable boundary comprises heat treated areas of said mixture of heat-meltable and non-heat-meltable material, wherein the heat treatment reduces absorbance of the heat treated areas, wherein said layer of flat material further comprising at least one absorbent connector, said absorbent connector being disposed such that said sample application area and said detection area are connected by said absorbent connector, wherein said liquid impermeable boundary and said absorbent connector prevent liquid from being transported between said at least one sample application area and said at least one detection area, except through said absorbent connector.
Claim 50
Dependent Claim
43 words
An analytical device as recited in claim 41, wherein said at least one detection area is a plurality of detection areas, each of said plurality of detection areas being connected to said sample application area by a corresponding plurality of said absorbent connectors.
Claim 51
Dependent Claim
23 words
An analytical device as recited in claim 42, wherein said at least one sample application area is a plurality of sample application areas.
Claim 52
Dependent Claim
37 words
An analytical device as recited in claim 41, wherein said liquid-impermeable boundary comprises a material which is not a same material as the layer of material comprising the absorbent sample application area and the absorbent detection area.
Claim 53
Dependent Claim
33 words
An analytical device as recited in claim 41, wherein a surface area of said at least one sample application area is larger than a surface area of said at least one detection area.
Claim 54
Dependent Claim
27 words
An analytical device as recited in claim 41, wherein the at least one sample application area and the at least one detection area comprise a fibrous material.
Claim 55
Dependent Claim
24 words
An analytical device as recited in claim 41, wherein at least one sample application area, detection area, and absorbent connector comprise a porous material.
Claim 56
Dependent Claim
20 words
An analytical device as recited in claim 41, wherein said layer of flat material has a consistent chemical make-up throughout.
Claim 57
Dependent Claim
29 words
An analytical device as recited in claim 41, wherein said sample application area and said detection area are located on a same surface of said layer of flat material.
Claim 58
Dependent Claim
197 words
A process for manufacturing an analytical device for determining an analyte in a liquid sample, said process comprising the steps of: providing a layer of flat absorbent first material; forming at least one absorbent sample application area on said layer of flat first material; forming at least one absorbent detection area on said layer of flat first material; forming at least one absorbent connector connecting said at least one sample application area and said at least one detection area; providing a heat-deformable second material; locating said heat-deformable second material under said layer of flat first material, wherein said steps of forming the sample application area, forming the detection area, and forming the absorbent connector are performed by heat-treatment of the heat-deformable second material such that the absorbent flat first material is affected in selected areas so that it is no longer absorbent, wherein said at least one sample application area, said at least one detection area, and said absorbent connector are disposed within a liquid impermeable boundary, said liquid impermeable boundary being formed during said forming steps, and wherein said at least one absorbent detection area includes a reagent for determining the analyte in a liquid sample.
Claim 59
Dependent Claim
197 words
A process for manufacturing an analytical device for determining an analyte in a liquid sample, said process comprising the steps of: providing a layer of flat absorbent first material; forming at least one absorbent sample application area on said layer of flat first material; forming at least one absorbent detection area on said layer of flat first material; forming at least one absorbent connector connecting said at least one sample application area and said at least one detection area; providing a heat-deformable second material; locating said heat-deformable second material under said layer of flat first material, wherein said steps of forming the sample application area, forming the detection area, and forming the absorbent connector are performed by heat-treatment of the heat-deformable second material such that the absorbent flat first material is affected in selected areas so that it is no longer absorbent, wherein said at least one sample application area, said at least one detection area, and said absorbent connector are disposed within a liquid impermeable boundary, said liquid impermeable boundary being formed during said forming steps, and wherein said at least one absorbent detection area includes a reagent for determining the analyte in a liquid sample.
Claim 60
Dependent Claim
161 words
A process for manufacturing an analytical device for determining an analyte in a liquid sample, said process comprising the steps of: providing a layer of flat absorbent first material; forming at least one absorbent sample application area on said layer of flat first material; forming at least one absorbent detection area on said layer of flat first material; forming at least one absorbent connector connecting said at least one sample application area and said at least one detection area, said at least one absorbent connector having a cross-section which is less than a cross-section of the sample application area and a cross-section of the detection area, wherein said at least one sample application area, said at least one detection area, and said absorbent connector are disposed within a liquid impermeable boundary, said liquid impermeable boundary being formed during said forming steps, and wherein said at least one absorbent detection area includes a reagent for determining the analyte in a liquid sample.
Claim 61
Dependent Claim
161 words
A process for manufacturing an analytical device for determining an analyte in a liquid sample, said process comprising the steps of: providing a layer of flat absorbent first material; forming at least one absorbent sample application area on said layer of flat first material; forming at least one absorbent detection area on said layer of flat first material; forming at least one absorbent connector connecting said at least one sample application area and said at least one detection area, said at least one absorbent connector having a cross-section which is less than a cross-section of the sample application area and a cross-section of the detection area, wherein said at least one sample application area, said at least one detection area, and said absorbent connector are disposed within a liquid impermeable boundary, said liquid impermeable boundary being formed during said forming steps, and wherein said at least one absorbent detection area includes a reagent for determining the analyte in a liquid sample.
Claim 62
Dependent Claim
47 words
A process for manufacturing an analytical device as recited in claim 51, wherein said steps of forming said sample application area, forming said detection area, and forming said absorbent connector comprises heat treatment of portions of said layer of flat first material forming the liquid impermeable boundaries.
Claim 63
Dependent Claim
20 words
A process for manufacturing an analytical device as recited in claim 52, wherein said heat treatment is performed with ultrasound.
Claim 64
Dependent Claim
80 words
A process for manufacturing an analytical device as recited in claim 51, further comprising the steps of: providing a heat-deformable second material; locating said heat-deformable second material under said layer of flat first material, wherein said steps of forming the sample application area, forming the detection area, and forming the absorbent connector are performed by heat-treatment of the heat-deformable second material such that the absorbent flat first material is affected in selected areas so that it is no longer absorbent.
Claim 65
Dependent Claim
168 words
A process for manufacturing an analytical device for determining an analyte in a liquid sample, said process comprising the steps of: providing a layer of flat absorbent first material; forming at least one absorbent sample application area on said layer of flat first material; forming at least one absorbent detection area on said layer of flat first material; forming at least one absorbent connector connecting said at least one sample application area and said at least one detection area, wherein said at least one sample application area, said at least one detection area, and said absorbent connector are disposed within a liquid impermeable boundary, said liquid impermeable boundary being formed during said forming steps, and wherein said at least one absorbent detection area includes a reagent for determining the analyte in a liquid sample, said layer of flat absorbent material being a heat-meltable material wherein said liquid-impermeable boundaries comprise heat treated areas of said heat-meltable material, wherein the heat treatment reduces the absorbency of the heat treated areas.
Claim 66
Dependent Claim
168 words
A process for manufacturing an analytical device for determining an analyte in a liquid sample, said process comprising the steps of: providing a layer of flat absorbent first material; forming at least one absorbent sample application area on said layer of flat first material; forming at least one absorbent detection area on said layer of flat first material; forming at least one absorbent connector connecting said at least one sample application area and said at least one detection area, wherein said at least one sample application area, said at least one detection area, and said absorbent connector are disposed within a liquid impermeable boundary, said liquid impermeable boundary being formed during said forming steps, and wherein said at least one absorbent detection area includes a reagent for determining the analyte in a liquid sample, said layer of flat absorbent material being a heat-meltable material wherein said liquid-impermeable boundaries comprise heat treated areas of said heat-meltable material, wherein the heat treatment reduces the absorbency of the heat treated areas.
Claim 67
Dependent Claim
47 words
A process for manufacturing an analytical device as recited in claim 55, wherein said steps of forming said sample application area, forming said detection area, and forming said absorbent connector comprises heat treatment of portions of said layer of flat first material forming the liquid impermeable boundaries.
Claim 68
Dependent Claim
80 words
A process for manufacturing an analytical device as recited in claim 55, further comprising the steps of: providing a heat-deformable second material; locating said heat-deformable second material under said layer of flat first material, wherein said steps of forming the sample application area, forming the detection area, and forming the absorbent connector are performed by heat-treatment of the heat-deformable second material such that the absorbent flat first material is affected in selected areas so that it is no longer absorbent.
Claim 69
Dependent Claim
173 words
A process for manufacturing an analytical device for determining an analyte in a liquid sample, said process comprising the steps of: providing a layer of flat absorbent first material; forming at least one absorbent sample application area on said layer of flat first material; forming at least one absorbent detection area on said layer of flat first material; forming at least one absorbent connector connecting said at least one sample application area and said at least one detection area, wherein said at least one sample application area, said at least one detection area, and said absorbent connector are disposed within a liquid impermeable boundary, said liquid impermeable boundary being formed during said forming steps, and wherein said at least one absorbent detection area includes a reagent for determining the analyte in a liquid sample, and wherein said layer of flat material comprises a mixture of heat-meltable and non-heat-meltable material, wherein said liquid impermeable boundary comprises heat treated areas of said heat-meltable material, wherein the heat treatment reduces absorbance of the heat treated areas.
Claim 70
Dependent Claim
173 words
A process for manufacturing an analytical device for determining an analyte in a liquid sample, said process comprising the steps of: providing a layer of flat absorbent first material; forming at least one absorbent sample application area on said layer of flat first material; forming at least one absorbent detection area on said layer of flat first material; forming at least one absorbent connector connecting said at least one sample application area and said at least one detection area, wherein said at least one sample application area, said at least one detection area, and said absorbent connector are disposed within a liquid impermeable boundary, said liquid impermeable boundary being formed during said forming steps, and wherein said at least one absorbent detection area includes a reagent for determining the analyte in a liquid sample, and wherein said layer of flat material comprises a mixture of heat-meltable and non-heat-meltable material, wherein said liquid impermeable boundary comprises heat treated areas of said heat-meltable material, wherein the heat treatment reduces absorbance of the heat treated areas.
Claim 71
Dependent Claim
47 words
A process for manufacturing an analytical device as recited in claim 58, wherein said steps of forming said sample application area, forming said detection area, and forming said absorbent connector comprises heat treatment of portions of said layer of flat first material forming the liquid impermeable boundaries.
Claim 72
Dependent Claim
20 words
A process for manufacturing an analytical device as recited in claim 59, wherein said heat treatment is performed with ultrasound.
Claim 73
Dependent Claim
80 words
A process for manufacturing an analytical device as recited in claim 58, further comprising the steps of: providing a heat-deformable second material; locating said heat-deformable second material under said layer of flat first material, wherein said steps of forming the sample application area, forming the detection area, and forming the absorbent connector are performed by heat-treatment of the heat-deformable second material such that the absorbent flat first material is affected in selected areas so that it is no longer absorbent.
Claim 74
Dependent Claim
35 words
An analytical device as recited in claim 1, further comprising absorbent functional areas within said liquid impermeable boundary, said absorbent functional areas interrupting said absorbent connector between said sample application area and said detection area.
Claim 75
Dependent Claim
25 words
An analytical device as recited in claim 62, wherein said functional areas have a cross-section which is greater than a cross-section of the absorbent connector.
Claim 76
Dependent Claim
35 words
An analytical device as recited in claim 18, further comprising absorbent functional areas within said liquid impermeable boundary, said absorbent functional areas interrupting said absorbent connector between said sample application area and said detection area.
Claim 77
Dependent Claim
25 words
An analytical device as recited in claim 64, wherein said functional areas have a cross-section which is greater than a cross-section of the absorbent connector.
Claim 78
Dependent Claim
35 words
An analytical device as recited in claim 21, further comprising absorbent functional areas within said liquid impermeable boundary, said absorbent functional areas interrupting said absorbent connector between said sample application area and said detection area.
Claim 79
Dependent Claim
25 words
An analytical device as recited in claim 66, wherein said functional areas have a cross-section which is greater than the cross-section of the absorbent connector.
Claim 80
Dependent Claim
35 words
An analytical device as recited in claim 32, further comprising absorbent functional areas within said liquid impermeable boundary, said absorbent functional areas interrupting said absorbent connector between said sample application area and said detection area.
Claim 81
Dependent Claim
25 words
An analytical device as recited in claim 68, wherein said functional areas have a cross-section which is greater than a cross-section of the absorbent connector.
Claim 82
Dependent Claim
35 words
An analytical device as recited in claim 41, further comprising absorbent functional areas within said liquid impermeable boundary, said absorbent functional areas interrupting said absorbent connector between said sample application area and said detection area.
Claim 83
Dependent Claim
25 words
An analytical device as recited in claim 70, wherein said functional areas have a cross-section which is greater than a cross-section of the absorbent connector.
Claim 84
Dependent Claim
46 words
A process for manufacturing an analytical device as recited in claim 9, further comprising the step of forming at least one absorbent functional area within said liquid impermeable boundary, said absorbent functional area interrupting said absorbent connector between said sample application area and said detection area.
Claim 85
Dependent Claim
32 words
A process for manufacturing an analytical device as recited in claim 72, wherein said absorbent functional area is formed with a cross-section which is larger than a cross-section of the absorbent connector.
Claim 86
Dependent Claim
46 words
A process for manufacturing an analytical device as recited in claim 12, further comprising the step of forming at least one absorbent functional area within said liquid impermeable boundary, said absorbent functional area interrupting said absorbent connector between said sample application area and said detection area.
Claim 87
Dependent Claim
32 words
A process for manufacturing an analytical device as recited in claim 74, wherein said absorbent functional area is formed with a cross-section which is larger than a cross-section of the absorbent connector.
Claim 88
Dependent Claim
46 words
A process for manufacturing an analytical device as recited in claim 14, further comprising the step of forming at least one absorbent functional area within said liquid impermeable boundary, said absorbent functional area interrupting said absorbent connector between said sample application area and said detection area.
Claim 89
Dependent Claim
32 words
A process for manufacturing an analytical device as recited in claim 76, wherein said absorbent functional area is formed with a cross-section which is larger than a cross-section of the absorbent connector.
Claim 90
Dependent Claim
46 words
A process for manufacturing an analytical device as recited in claim 50, further comprising the step of forming at least one absorbent functional area within said liquid impermeable boundary, said absorbent functional area interrupting said absorbent connector between said sample application area and said detection area.
Claim 91
Dependent Claim
32 words
A process for manufacturing an analytical device as recited in claim 78, wherein said absorbent functional area is formed with a cross-section which is larger than a cross-section of the absorbent connector.
Claim 92
Dependent Claim
46 words
A process for manufacturing an analytical device as recited in claim 51, further comprising the step of forming at least one absorbent functional area within said liquid impermeable boundary, said absorbent functional area interrupting said absorbent connector between said sample application area and said detection area.
Claim 93
Dependent Claim
32 words
A process for manufacturing an analytical device as recited in claim 80, wherein said absorbent functional area is formed with a cross-section which is larger than the cross-section of the absorbent connector.
Claim 94
Dependent Claim
46 words
A process for manufacturing an analytical device as recited in claim 55, further comprising the step of forming at least one absorbent functional area within said liquid impermeable boundary, said absorbent functional area interrupting said absorbent connector between said sample application area and said detection area.
Claim 95
Dependent Claim
32 words
A process for manufacturing an analytical device as recited in claim 82, wherein said absorbent functional area is formed with a cross-section which is larger than a cross-section of the absorbent connector.
Claim 96
Dependent Claim
46 words
A process for manufacturing an analytical device as recited in claim 58, further comprising the step of forming at least one absorbent functional area within said liquid impermeable boundary, said absorbent functional area interrupting said absorbent connector between said sample application area and said detection area.
Claim 97
Dependent Claim
32 words
A process for manufacturing an analytical device as recited in claim 84, wherein said absorbent functional area is formed with a cross-section which is larger than a cross-section of the absorbent connector.
References Cited (Backward Citations)
DE2934760A1
Cited
US4235601A
Cited
DE3222366A1
Cited
EP0126357A1
Cited
EP0133895A1
Cited
DE3442820A1
Cited
EP0166365A2
Cited
EP0185982A1
Cited
US4678757A
Cited
EP0199205A1
Cited
EP0209032A2
Cited
US4837373A
Cited
EP0443231A1
Cited
USPTO Annuity & Maintenance Windows
| Annuity Stage | Window Opens | Payment Deadline | Surcharge Period Until | Estimated Fee | Status |
|---|---|---|---|---|---|
| 3.5 Years (Year 4) | 1998-09-18 | 1999-03-20 | 1999-09-19 | $2000.00 | Window Closed / Lapsed |
| 7.5 Years (Year 8) | 2002-09-18 | 2003-03-20 | 2003-09-19 | $3760.00 | Window Closed / Lapsed |
| 11.5 Years (Year 12) | 2006-09-18 | 2007-03-20 | 2007-09-19 | $7700.00 | Window Closed / Lapsed |