EP0209032A2
Expired / Lapsed
EP
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Multilayer analytical element and method of making, using ultrasonic or laser energy
Assignee: Bayer Corp
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Filing: 1986-07-07
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Granted: —
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Expires: 2006-07-07
Abstract
Abstract A method of making a multilayer analytical test element comprising providing a plurality of layers at least one of which is responsive to detect a ligand in a liquid sample, or to detect the ligand binding capacity of the sample, and at least one other layer that is fusible when subjected to sonic energy, arranging said plurality of layers one on top of the other together to form a composite blank of said layers, subjecting said composite to ultrasonic or laser energy to cut said composite to the desired dimension of the test element and to simultaneously weld said plurality of layers at the edges thereof, said energy softening and fusing said fusible layer to thereby bond said plurality of layers together.
Inventors
- 👤 Steven C. Charlton
- 👤 Bert Walter
Bibliographic Details
Application Number
—
Jurisdiction
EP
Data Source
google_patents
Last Synchronized
2026-10-23 05:21
CPC Classifications
B; B32; B32B; B32B5/00; B32B5/02; B32B5/028; B32B27/00; B32B27/06; B32B27/10; B32B5/22; B32B5/24; B32B5/26; G; G01; G01N; G01N33/00; G01N33/48; G01N33/50; G01N33/52; G01N33/525; B32B2260/00; B32B2260/04; B32B2310/00; B32B2310/028; Y; Y10; Y10S; Y10S435/00; Y10S435/805
Claims Analysis
Total Claims: 14
Claim 1
Independent Claim
74 words
A multilayer analytical test element comprising a plurality of layers at least one of which is responsive to detect a ligand in, or detect the ligand binding capacity of, a liquid sample, and at least one of said layers being a fusible layer, said layers having been bonded together at their respective edges by ultrasonic or laser energy which is used to cut said element from a composite blank of said plurality of layers.
Claim 2
Dependent Claim
74 words
A multilayer analytical test element comprising a plurality of layers at least one of which is responsive to detect a ligand in, or detect the ligand binding capacity of, a liquid sample, and at least one of said layers being a fusible layer, said layers having been bonded together at their respective edges by ultrasonic or laser energy which is used to cut said element from a composite blank of said plurality of layers.
Claim 3
Dependent Claim
15 words
The test element according to claim 1 wherein said fusible layer is a thermoplastic mesh.
Claim 4
Dependent Claim
16 words
The test element according to claim 2 wherein said mesh is a woven or non-woven fabric.
Claim 5
Dependent Claim
129 words
A multilayer analytical test element comprising a first responsive layer having been impregnated with a reagent and which is responsive to detect a ligand in, or the ligand binding capacity of, a liquid sample, a second responsive layer having been impregnated with a reagent and which is responsive to detect a ligand in, or the liquid binding capacity of a liquid sample, and a third layer which is a fusible thermoplastic material and which is positioned adjacent to said first and second responsive layers, said first and second responsive layers having been bonded together at their respective edges by ultrasonic or laser energy which is used to cut said element from a composite blank of said plurality of layers which is of larger surface area than said test element.
Claim 6
Dependent Claim
129 words
A multilayer analytical test element comprising a first responsive layer having been impregnated with a reagent and which is responsive to detect a ligand in, or the ligand binding capacity of, a liquid sample, a second responsive layer having been impregnated with a reagent and which is responsive to detect a ligand in, or the liquid binding capacity of a liquid sample, and a third layer which is a fusible thermoplastic material and which is positioned adjacent to said first and second responsive layers, said first and second responsive layers having been bonded together at their respective edges by ultrasonic or laser energy which is used to cut said element from a composite blank of said plurality of layers which is of larger surface area than said test element.
Claim 7
Dependent Claim
26 words
The multilayer analytical test element according to claim 4, said first and second responsive layers being paper and said thermoplastic material being a screen positioned therebetween.
Claim 8
Dependent Claim
50 words
The multilayer analytical test element according to any of claims 4 and 5, further comprising a plurality of paper layers as the responsive layers each of which is impregnated with a different selected reagent which are mutually incompatible with each other and a thermoplastic screen positioned between adjacent paper layers.
Claim 9
Dependent Claim
21 words
The multilayer analytical test element according to any of clains 4 to 6 wherein said thermoplastic layer is a thermoplastic mesh.
Claim 10
Dependent Claim
21 words
The multilayer analytical test element according to any of clains 4 to 6 wherein said thermoplastic layer is a thermoplastic mesh.
Claim 11
Independent Claim
126 words
A method of making a multilayer analytical test element comprising providing a plurality of layers at least one of which is responsive to detect a ligand in, or to detect the ligand binding capacity of, a liquid sample and at least one other layer that is fusible when subjected to ultrasonic or laser energy, arranging said plurality of layers one on top of the other together to form a composite blank of said layers, subjecting said composite to ultrasonic or laser energy of sufficient energy to cut said composite to the desired dimension of the test element and to simultaneously weld said plurality of layers at their respective edges only, said energy softening and fusing said fusible layer to thereby bond said plurality of layers together.
Claim 12
Independent Claim
126 words
A method of making a multilayer analytical test element comprising providing a plurality of layers at least one of which is responsive to detect a ligand in, or to detect the ligand binding capacity of, a liquid sample and at least one other layer that is fusible when subjected to ultrasonic or laser energy, arranging said plurality of layers one on top of the other together to form a composite blank of said layers, subjecting said composite to ultrasonic or laser energy of sufficient energy to cut said composite to the desired dimension of the test element and to simultaneously weld said plurality of layers at their respective edges only, said energy softening and fusing said fusible layer to thereby bond said plurality of layers together.
Claim 13
Dependent Claim
89 words
The method of making a multilayer analytical test element according to claim 8, further comprising arranging said plurality of layers in alternating manner so that a fusible layer is adjacent a layer responsive to a ligand, generating ultrasonically varying forces along a line having a finite width, moving said plurality of layers to said line of ultrasonically generated force whereby the application of said ultrasonic forces cuts said plurality of layers in accordance with the desired configuration and simultaneously welds their respective edges to form an integral test element.
Claim 14
Independent Claim
28 words
The method of making a multilayer analytical test element according to any of claims 8 and 9, said fusible layer being a thermoplastic resin woven or nonwoven mesh.
References Cited (Backward Citations)
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