Patent US5439954A successfully refreshed from Google Patents.
US5439954A
Expired / Lapsed
US
⏱️ 0.0 years remaining
Substituted phenyl-1,3-diketones as protectants against skin damage
Assignee: Procter and Gamble Co
•
Filing: 1991-10-11
•
Granted: 1995-08-08
•
Expires: 2011-10-11
Abstract
Abstract The subject invention relates to pharmaceutical compositions comprising a safe and effective amount of a compound having the structure: <IMAGE> wherein each R is alkyl or hydrogen, at least two being alkyl; R' is hydrogen, alkyl or aryl; R'' is alkyl or halo; and each X is independently oxygen or sulfur; and a pharmaceutically-acceptable carrier. The subject invention also relates to methods for preventing damage to skin by topically applying a safe and effective amount of such compounds to the skin.
Inventors
- 👤 Rodney D. Bush
Bibliographic Details
Application Number
—
Jurisdiction
US
Data Source
google_patents
Last Synchronized
2026-11-09 04:50
CPC Classifications
A; A61; A61Q; A61Q17/00; A61Q17/04; A61K; A61K8/00; A61K8/18; A61K8/30; A61K8/33; A61K8/35; Y; Y10; Y10S; Y10S424/00; Y10S424/05
Claims Analysis
Total Claims: 18
Claim 1
Independent Claim
68 words
A photoprotective composition comprising: A. A safe and effective amount of a compound having the structure: ##STR5## wherein each R is independently C 1 -C 20 alkyl or hydrogen, at least two being alkyl; R' is hydrogen, or C 1 -C 20 alkyl or aryl; R" is C 1 -C 20 alkyl or halo; and each X is independently oxygen or sulfur; and B. a cosmetically-acceptable topical carrier.
Claim 2
Dependent Claim
68 words
A photoprotective composition comprising: A. A safe and effective amount of a compound having the structure: ##STR5## wherein each R is independently C 1 -C 20 alkyl or hydrogen, at least two being alkyl; R' is hydrogen, or C 1 -C 20 alkyl or aryl; R" is C 1 -C 20 alkyl or halo; and each X is independently oxygen or sulfur; and B. a cosmetically-acceptable topical carrier.
Claim 3
Dependent Claim
9 words
The composition of claim 1 wherein R" is alkyl.
Claim 4
Dependent Claim
9 words
The composition of claim 1 wherein R' is hydrogen.
Claim 5
Dependent Claim
32 words
The composition of claim 2 wherein each alkyl R is C 1 -C 4 , R' is hydrogen or C 1 -C 8 alkyl, and R" is C 1 -C 8 alkyl.
Claim 6
Dependent Claim
16 words
The composition of claim 4 wherein each alkyl R, R' and R" is unsubstituted and saturated.
Claim 7
Dependent Claim
9 words
The composition of claim 5 wherein R' is hydrogen.
Claim 8
Dependent Claim
10 words
The composition of claim 6 wherein each X is oxygen.
Claim 9
Dependent Claim
21 words
The composition of claim 7 wherein R" is C 1 -C 4 , and each alkyl R is methyl or ethyl.
Claim 10
Dependent Claim
15 words
The composition of claim 8 wherein each alkyl R is methyl and R" is methyl.
Claim 11
Dependent Claim
20 words
The composition of any of claims 1, 5, 8 or 9 wherein at least 3 of the R's are alkyl.
Claim 12
Dependent Claim
13 words
The composition of claim 9 wherein all four R's and R" are methyl.
Claim 13
Dependent Claim
28 words
The composition of claim 9 wherein the three R's in the 2'-, 3'- and 4'-positions are methyl, the R in the 5'-position is hydrogen, and R" is methyl.
Claim 14
Dependent Claim
36 words
The composition of any of claims 1, 5, 8, 9, 11 and 12 wherein the composition comprises from about 0.5% to about 10% of the compound and from about 5% to about 20% of an emollient.
Claim 15
Dependent Claim
36 words
The composition of any of claims 1, 7 and 9 wherein the composition also comprises an active agent selected from the group consisting of a sunscreen, a sunblock, an anti-inflammatory, an antioxidant and a radical scavenger.
Claim 16
Dependent Claim
18 words
The composition of any of claims 1, 7 and 9 wherein the composition comprises an additional sunscreen compound.
Claim 17
Independent Claim
36 words
A method for protecting the skin of a human or lower animal from radiation by topically administering to the skin a safe and effective amount of the composition of any of claims 1, 7 and 9.
Claim 18
Independent Claim
49 words
A method for protecting the skin of a human or lower animal from radiation by topically administering to the skin a safe and effective amount of the composition of any of claims 1, 5, 8, 9, 11 and 12 at least about once daily for more than 6 months.
References Cited (Backward Citations)
US3082071A
Cited
US3937737A
Cited
US4082807A
Cited
US4065502A
Cited
US4175012A
Cited
US3994869A
Cited
US4015980A
Cited
US4489057A
Cited
US4152396A
Cited
US4123400A
Cited
BE856814A
Cited
US4387089A
Cited
US4710373A
Cited
EP0313305A2
Cited
US4988501A
Cited
JPH02227484A
Cited
US5191121A
Cited
EP0431755A1
Cited
WO1991016034A1
Cited
WO1991016035A1
Cited
USPTO Annuity & Maintenance Windows
| Annuity Stage | Window Opens | Payment Deadline | Surcharge Period Until | Estimated Fee | Status |
|---|---|---|---|---|---|
| 3.5 Years (Year 4) | 1998-08-07 | 1999-02-06 | 1999-08-08 | $2000.00 | Window Closed / Lapsed |
| 7.5 Years (Year 8) | 2002-08-07 | 2003-02-06 | 2003-08-08 | $3760.00 | Window Closed / Lapsed |
| 11.5 Years (Year 12) | 2006-08-07 | 2007-02-06 | 2007-08-08 | $7700.00 | Window Closed / Lapsed |