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Patent US5436228A successfully refreshed from Google Patents.
US5436228A
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Chemotactic wound healing peptides
Assignee: Research Corp
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Filing: 1993-09-28
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Granted: 1995-07-25
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Expires: 2013-09-28
Abstract
Abstract Peptides corresponding to an no acid sequences in the C-terminal region of TGF- beta are provided. The peptides all contain at least a seven amino acid sequence substantially corresponding to the amino acid sequence of TGF- beta 1 amino acids 368-374: VYYVGRK, as well as homologs and analogs thereof. The peptides have chemotactic activity towards fibroblasts, monocytes and neutrophils and induce fibroblast proliferation and collagen synthesis. The peptides may be used in compositions and methods for promoting wound healing.
Inventors
- 👤 Arnold E. Postlethwaite
- 👤 Jerome Seyer
- 👤 Andrew Kang
Bibliographic Details
Application Number
—
Jurisdiction
US
Data Source
google_patents
Last Synchronized
2026-11-08 17:16
CPC Classifications
C; C07; C07K; C07K14/00; C07K14/435; C07K14/475; C07K14/495; A; A61; A61K; A61K38/00
Claims Analysis
Total Claims: 23
Claim 1
Independent Claim
23 words
A chemotactic peptide having an amino acid sequence as set forth in SEQ ID NO. 1, or a homolog, or an analog thereof.
Claim 2
Dependent Claim
23 words
A chemotactic peptide having an amino acid sequence as set forth in SEQ ID NO. 1, or a homolog, or an analog thereof.
Claim 3
Dependent Claim
41 words
A chemotactic peptide wherein the amino acid sequence of the peptide is selected from the group consisting of SEQ ID NO. 1, SEQ. ID NO. 2, SEQ ID NO. 3, SEQ ID NO. 4, SEQ ID NO. 5 and analogs thereof.
Claim 4
Dependent Claim
41 words
A chemotactic peptide wherein the amino acid sequence of the peptide is selected from the group consisting of SEQ ID NO. 1, SEQ. ID NO. 2, SEQ ID NO. 3, SEQ ID NO. 4, SEQ ID NO. 5 and analogs thereof.
Claim 5
Dependent Claim
41 words
A chemotactic peptide wherein the amino acid sequence of the peptide is selected from the group consisting of SEQ ID NO. 6, SEQ ID NO. 7, SEQ ID NO. 8, SEQ ID NO. 9, SEQ ID NO. 10 and analogs thereof.
Claim 6
Dependent Claim
41 words
A chemotactic peptide wherein the amino acid sequence of the peptide is selected from the group consisting of SEQ ID NO. 6, SEQ ID NO. 7, SEQ ID NO. 8, SEQ ID NO. 9, SEQ ID NO. 10 and analogs thereof.
Claim 7
Dependent Claim
41 words
A chemotactic peptide wherein the amino acid sequence of the peptide is selected from the group consisting of SEQ ID NO. 11, SEQ ID NO. 12, SEQ ID NO. 13, SEQ ID NO. 14, SEQ ID NO. 15 and analogs thereof.
Claim 8
Dependent Claim
41 words
A chemotactic peptide wherein the amino acid sequence of the peptide is selected from the group consisting of SEQ ID NO. 11, SEQ ID NO. 12, SEQ ID NO. 13, SEQ ID NO. 14, SEQ ID NO. 15 and analogs thereof.
Claim 9
Dependent Claim
40 words
A chemotactic peptide wherein the amino acid sequence of the peptide is selected from the group consisting of SEQ ID NO. 16, SEQ ID NO. 17, SEQ ID NO. 18, SEQ ID NO. 19, SEQ ID NO. 20 and analogs.
Claim 10
Dependent Claim
40 words
A chemotactic peptide wherein the amino acid sequence of the peptide is selected from the group consisting of SEQ ID NO. 16, SEQ ID NO. 17, SEQ ID NO. 18, SEQ ID NO. 19, SEQ ID NO. 20 and analogs.
Claim 11
Independent Claim
41 words
A method for inducing either in vitro or in vivo chemotaxis of fibroblasts and/or inflammatory cells comprising administering to the fibroblasts and/or inflammatory cells at least one peptide of any one of claims 1-5 in an amount effective to induce chemotaxis.
Claim 12
Independent Claim
45 words
A method for inducing or a homolog thereof and a pharmaceutically acceptable carrier proliferation of fibroblasts and/or inflammatory cells comprising administering to the fibroblasts and/or inflammatory cells at least one peptide of any one of claims 1-5 in an amount effective to induce cellular proliferation.
Claim 13
Independent Claim
37 words
A method for inducing either in vitro or in vivo collagen synthesis by fibroblasts comprising administering to the fibroblasts at least one peptide of any one of claims 1-5 in an amount effective to induce collagen synthesis.
Claim 14
Independent Claim
35 words
A method for promoting wound healing in a patient comprising administering to the patient at least one peptide of any one of claims 1-5 in an amount effective to promote wound healing in the patient.
Claim 15
Dependent Claim
18 words
A chemotactic peptide consisting of a seven amino acid sequence as set forth in SEQ ID NO. 1.
Claim 16
Dependent Claim
18 words
A chemotactic peptide consisting of a seven amino acid sequence as set forth in SEQ ID NO. 1.
Claim 17
Dependent Claim
35 words
A chemotactic peptide having an amino acid sequence selected from the group consisting of SEQ ID NO. 1, SEQ ID NO. 2, SEQ ID NO. 3, SEQ ID NO. 4 and SEQ ID NO. 5.
Claim 18
Dependent Claim
35 words
A chemotactic peptide having an amino acid sequence selected from the group consisting of SEQ ID NO. 1, SEQ ID NO. 2, SEQ ID NO. 3, SEQ ID NO. 4 and SEQ ID NO. 5.
Claim 19
Dependent Claim
25 words
An analog of a chemotactic peptide set forth in SEQ ID NO. 6 having a cysteine residue attached to the C-terminal end of said peptide.
Claim 20
Dependent Claim
25 words
An analog of a chemotactic peptide set forth in SEQ ID NO. 6 having a cysteine residue attached to the C-terminal end of said peptide.
Claim 21
Dependent Claim
28 words
An analog of a chemotactic peptide set forth in any one of claims 1-5 having a cysteine residue attached to the C-terminal or N-terminal end of said peptide.
Claim 22
Dependent Claim
12 words
A pharmaceutical composition comprising either a peptide of SEQ ID NO. 1.
Claim 23
Dependent Claim
12 words
A pharmaceutical composition comprising either a peptide of SEQ ID NO. 1.
References Cited (Backward Citations)
US5104977A
Cited
US4806523A
Cited
US5008240A
Cited
US4971952A
Cited
US5055447A
Cited
JPH02152988A
Cited
US5061786A
Cited
WO1991003491A1
Cited
WO1991005565A1
Cited
EP0542679A1
Cited
USPTO Annuity & Maintenance Windows
| Annuity Stage | Window Opens | Payment Deadline | Surcharge Period Until | Estimated Fee | Status |
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| 3.5 Years (Year 4) | 1998-07-24 | 1999-01-23 | 1999-07-25 | $2000.00 | Window Closed / Lapsed |
| 7.5 Years (Year 8) | 2002-07-24 | 2003-01-23 | 2003-07-25 | $3760.00 | Window Closed / Lapsed |
| 11.5 Years (Year 12) | 2006-07-24 | 2007-01-23 | 2007-07-25 | $7700.00 | Window Closed / Lapsed |