US5428008A
Expired / Lapsed
US
⏱️ 0.0 years remaining
Therapeutic composition of micellar structures capable of promoting hemotasis
Assignee: PRP Inc
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Filing: 1991-10-31
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Granted: 1995-06-27
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Expires: 2011-10-31
Abstract
Abstract A reconstituted platelet membrane vesicle or micellar structure preparation is provided. The preparation, directed at promoting hemostasis, may be prepared from proteins and lipids derived from either synthetic sources or from mammalian platelet membranes. The product may be used for transfusions or may be topically applied. Methods for forming the vesicles or micellar structures and products for storing and dispensing the vesicles or micellar structures also are disclosed.
Inventors
- 👤 Francis C. Chao
- 👤 Frank H. Liang
Bibliographic Details
Application Number
—
Jurisdiction
US
Data Source
google_patents
Last Synchronized
2026-10-26 20:32
CPC Classifications
A; A61; A61K; A61K35/00; A61K35/12; A61K35/14; A61K35/19; A61K9/00; A61K9/10; A61K9/127; A61K9/1271; A61K9/48; A61K9/50; A61K9/5005; A61K9/5063; A61K9/5068; B; B82; B82Y; B82Y5/00; C; C07; C07K; C07K14/00; C07K14/435; C07K14/705; C07K14/70546; C07K14/70557; A61K38/00
Claims Analysis
Total Claims: 18
Claim 1
Independent Claim
28 words
A therapeutic composition comprising a pharmaceutically acceptable sterile preparation of micellar structures capable of promoting hemostasis, the micellar structures consisting essentially of a combination of glycoprotein and phospholipid.
Claim 2
Dependent Claim
28 words
A therapeutic composition comprising a pharmaceutically acceptable sterile preparation of micellar structures capable of promoting hemostasis, the micellar structures consisting essentially of a combination of glycoprotein and phospholipid.
Claim 3
Dependent Claim
15 words
The therapeutic composition of claim 1 wherein the glycoprotein:phospholipid ratio is between 1:20 and 3:5.
Claim 4
Dependent Claim
12 words
The therapeutic composition of claim 2 wherein the ratio is about 1:10.
Claim 5
Dependent Claim
23 words
The therapeutic composition of claim 1 wherein the glycoprotein comprises glycoprotein Ib and wherein the glycoprotein Ib:phospholipid ratio is between 1:50 and 3:5.
Claim 6
Dependent Claim
14 words
The therapeutic composition of claim 4 wherein the ratio is between 1:25 and 1:10.
Claim 7
Dependent Claim
22 words
The therapeutic composition of claim 1 wherein the glycoprotein comprises glycoprotein Ib and wherein the glycoprotein Ib: phospholipid ratio is about 1:10.
Claim 8
Dependent Claim
16 words
The therapeutic composition of claim 1 wherein the composition is free of glycoprotein IIb/glycoprotein IIIa complex.
Claim 9
Dependent Claim
28 words
The therapeutic composition of claim 1 wherein the lipid composition permits greater than 80% incorporation of the glycoprotein when the glycoprotein:phospholipid ratio as starting materials is about 1:10.
Claim 10
Dependent Claim
12 words
The therapeutic composition of claim 8 wherein the glycoprotein is glycoprotein Ib.
Claim 11
Dependent Claim
15 words
The therapeutic composition of claim 8 wherein the glycoprotein is glycoprotein IIb or glycoprotein IIIa.
Claim 12
Dependent Claim
18 words
The therapeutic composition of claim 1 wherein the micellar structures are formed of a phospholipid having procoagulant activity.
Claim 13
Dependent Claim
18 words
The therapeutic composition of claim 1 wherein the micellar structures are derived from non-human platelets and human platelets.
Claim 14
Dependent Claim
26 words
The therapeutic composition of claim 1 further comprising a therapeutic agent entrapped within the lumina of the micellar structures or incorporated in the micellar structure membrane.
Claim 15
Dependent Claim
20 words
The therapeutic composition of claim 1,2,3,4,5,6,7,8 or 11 wherein the material is formulated in an in vivo pharmaceutically effective preparation.
Claim 16
Dependent Claim
13 words
The therapeutic composition of claim 14 wherein the preparation comprises a bactericidal agent.
Claim 17
Dependent Claim
24 words
A pharmaceutical preparation comprising a pharmaceutically acceptable sterile preparation of micellar structures capable of promoting hemostasis, wherein the preparation is in a spray-bottle container.
Claim 18
Dependent Claim
24 words
A pharmaceutical preparation comprising a pharmaceutically acceptable sterile preparation of micellar structures capable of promoting hemostasis, wherein the preparation is in a spray-bottle container.
References Cited (Backward Citations)
USPTO Annuity & Maintenance Windows
| Annuity Stage | Window Opens | Payment Deadline | Surcharge Period Until | Estimated Fee | Status |
|---|---|---|---|---|---|
| 3.5 Years (Year 4) | 1998-06-26 | 1998-12-26 | 1999-06-27 | $2000.00 | Window Closed / Lapsed |
| 7.5 Years (Year 8) | 2002-06-26 | 2002-12-26 | 2003-06-27 | $3760.00 | Window Closed / Lapsed |
| 11.5 Years (Year 12) | 2006-06-26 | 2006-12-26 | 2007-06-27 | $7700.00 | Window Closed / Lapsed |