Patent US5419912A successfully refreshed from Google Patents.
US5419912A
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Adhesive patch for percutaneous delivery of isosorbide dinitrate
Assignee: Toko Yakuhin Kogyo KK
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Filing: 1994-05-16
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Granted: 1995-05-30
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Expires: 2014-05-16
Abstract
Abstract An adhesive patch for percutaneous delivery of isosorbide dinitrate includes a piece of separating paper; a percutaneous salve preparation which is solvent free and which is comprised of: (a) isosorbide dinitrate; (b) a percutaneous absorption accelerator which is at least one substance selected from the group consisting of a chained monocarboxylate and a higher alcohol; and (c) a tackifier composition as an additive, wherein the chained monocarboxylate is selected from the group consisting of isopropyl palmitate, isopropyl myristate, cetyl lactate, diethyl sebacate, xylol laurate, cetyl isooctanoate and lauryl lactate, wherein the higher alcohol is selected from the group consisting of cetanol, stearyl alcohol, lauryl alcohol, cetostearyl alcohol and myristyl alcohol, and wherein the percutaneous absorption accelerator is present in an amount ranging between 3 and 12 wt % if a chained monocarboxylate is used and between 1 and 3 wt % if a higher alcohol is used; and a surface coating material which is polymeric.
Inventors
- 👤 Yasunori Morimoto
- 👤 Kenji Sugibayashi
- 👤 Masatoshi Suzuki
Bibliographic Details
Application Number
—
Jurisdiction
US
Data Source
google_patents
Last Synchronized
2026-11-09 21:45
CPC Classifications
A; A61; A61K; A61K9/00; A61K9/70; A61K9/7023; A61K9/703; A61K9/7038; A61K9/7046; A61K9/7053; A61K31/00; A61K31/33; A61K31/335; A61K31/34; A61K47/00; A61K47/06; A61K47/08; A61K47/10; A61K47/14; A61K9/0012; A61K9/0014; A61K9/7061; A61K9/7069; A61K9/7076; A61P; A61P9/00
Claims Analysis
Total Claims: 7
Claim 1
Independent Claim
184 words
An adhesive patch for percutaneous delivery of isosorbide dinitrate, comprising: a sheet of paper; a percutaneous salve preparation which is applied to the sheet of paper, which consists of: (a) isosorbide dinitrate; (b) a percutaneous absorption accelerator which is at least one substance selected from the group consisting of a chained monocarboxylate and a higher alcohol; (c) a tackifier composition as an additive, wherein the chained monocarboxylate is selected from the group consisting of isopropyl palmitate, isopropyl myristate, cetyl lactate, diethyl sebacate, xylol laurate, cetyl isooctanoate and lauryl lactate; (d) a fluid paraffin softening agent; (e) at least one filler; and (f) at least one stabilizer, wherein the higher alcohol is selected from the group consisting of cetanol, stearyl alcohol, lauryl alcohol, cetostearyl alcohol and myristyl alcohol, and wherein the percutaneous absorption accelerator is present in an amount ranging between 3 and 12 wt % if a chained monocarboxylate is used and between 1 and 3 wt % if a higher alcohol is used; and a polymeric sheet which covers the percutaneous salve preparation and which is removable when the adhesive patch is used.
Claim 2
Dependent Claim
184 words
An adhesive patch for percutaneous delivery of isosorbide dinitrate, comprising: a sheet of paper; a percutaneous salve preparation which is applied to the sheet of paper, which consists of: (a) isosorbide dinitrate; (b) a percutaneous absorption accelerator which is at least one substance selected from the group consisting of a chained monocarboxylate and a higher alcohol; (c) a tackifier composition as an additive, wherein the chained monocarboxylate is selected from the group consisting of isopropyl palmitate, isopropyl myristate, cetyl lactate, diethyl sebacate, xylol laurate, cetyl isooctanoate and lauryl lactate; (d) a fluid paraffin softening agent; (e) at least one filler; and (f) at least one stabilizer, wherein the higher alcohol is selected from the group consisting of cetanol, stearyl alcohol, lauryl alcohol, cetostearyl alcohol and myristyl alcohol, and wherein the percutaneous absorption accelerator is present in an amount ranging between 3 and 12 wt % if a chained monocarboxylate is used and between 1 and 3 wt % if a higher alcohol is used; and a polymeric sheet which covers the percutaneous salve preparation and which is removable when the adhesive patch is used.
Claim 3
Dependent Claim
19 words
The percutaneous salve preparation according to claim 1, wherein the percutaneous absorption accelerator is isopropyl myristate and lauryl alcohol.
Claim 4
Dependent Claim
18 words
The adhesive patch according to claim 1, wherein the tackifier composition is comprised of a styrene-isoprene-styrene block copolymer.
Claim 5
Dependent Claim
25 words
The adhesive patch according to claim 1, wherein the polymeric sheet is a laminate of a layer of polyester and a layer of ethylene-vinylacetate copolymer.
Claim 6
Dependent Claim
233 words
An adhesive patch for percutaneous delivery of isosorbide dinitrate, comprising: a sheet of paper; a percutaneous salve preparation which is applied to the sheet of paper, which consists of: (a) isosorbide dinitrate; (b) a percutaneous absorption accelerator which is at least one substance selected from the group consisting of a chained monocarboxylate and a higher alcohol; (c) a tackifier composition as an additive, wherein the chained monocarboxylate is selected from the group consisting of isopropyl palmitate, isopropyl myristate, cetyl lactate, diethyl sebacate, xylol laurate, cetyl isooctanoate and lauryl lactate; (d) a fluid paraffin softening agent; (e) at least one filler; and (f) at least one stabilizer, wherein the higher alcohol is selected from the group consisting of cetanol, stearyl alcohol, lauryl alcohol, cetostearyl alcohol and myristyl alcohol, and wherein the percutaneous absorption accelerator is present in an amount ranging between 3 and 12 wt % if a chained monocarboxylate is used and between 1 and 3 wt % if a higher alcohol is used; and a polymeric sheet which covers the percutaneous salve preparation and which is removable when the adhesive patch is used, prepared by a process comprising: preparing a solution of isosorbide dinitrate, the percutaneous absorption accelerator, and the tackifier composition in a solvent; applying the solution to the sheet of paper; removing the solvent to provide the percutaneous salve preparation; and covering the percutaneous salve preparation with the polymeric sheet.
Claim 7
Dependent Claim
233 words
An adhesive patch for percutaneous delivery of isosorbide dinitrate, comprising: a sheet of paper; a percutaneous salve preparation which is applied to the sheet of paper, which consists of: (a) isosorbide dinitrate; (b) a percutaneous absorption accelerator which is at least one substance selected from the group consisting of a chained monocarboxylate and a higher alcohol; (c) a tackifier composition as an additive, wherein the chained monocarboxylate is selected from the group consisting of isopropyl palmitate, isopropyl myristate, cetyl lactate, diethyl sebacate, xylol laurate, cetyl isooctanoate and lauryl lactate; (d) a fluid paraffin softening agent; (e) at least one filler; and (f) at least one stabilizer, wherein the higher alcohol is selected from the group consisting of cetanol, stearyl alcohol, lauryl alcohol, cetostearyl alcohol and myristyl alcohol, and wherein the percutaneous absorption accelerator is present in an amount ranging between 3 and 12 wt % if a chained monocarboxylate is used and between 1 and 3 wt % if a higher alcohol is used; and a polymeric sheet which covers the percutaneous salve preparation and which is removable when the adhesive patch is used, prepared by a process comprising: preparing a solution of isosorbide dinitrate, the percutaneous absorption accelerator, and the tackifier composition in a solvent; applying the solution to the sheet of paper; removing the solvent to provide the percutaneous salve preparation; and covering the percutaneous salve preparation with the polymeric sheet.
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