Abstract A method for activating a mammalian immune system entails a series of continuous IL-2 infusions that are effected intermittently over an extended period. For example, IL-2 can be administered continuously for a period that is on the order of 5 days in length, and successive infusions of this nature can be separated by a period of at least 4 weeks. Sustained beneficial effects, including elevated CD4 cell counts, restoration of lymphocyte function and an increase in the number of IL-2 receptors, are achieved with such intermittent IL-2 therapy, which can be combined with another therapy which targets a specific disease state, such as an anti-retroviral therapy comprising, for example, the administration of AZT, ddI or interferon alpha.
A method for activating the immune system of a patient, comprising the step of administering an amount of IL-2 to said patient that is sufficient to increase the level of helper/inducer T-cell function in said patient, wherein: (A) said IL-2 is administered in a series of infusions effected intermittently, (B) each of said infusions is continuous over a period of time of from 1 day to 2 weeks, and (C) successive infusions are separated by a period of time of at least 4 weeks.
Claim 2
Independent Claim
84 words
A method for activating the immune system of a patient, comprising the step of administering an amount of IL-2 to said patient that is sufficient to increase the level of helper/inducer T-cell function in said patient, wherein: (A) said IL-2 is administered in a series of infusions effected intermittently, (B) each of said infusions is continuous over a period of time of from 1 day to 2 weeks, and (C) successive infusions are separated by a period of time of at least 4 weeks.
Claim 3
Dependent Claim
19 words
A method as claimed in claim 1, wherein said amount is sufficient to increase CD4 count in said patient.
Claim 4
Dependent Claim
23 words
A method as claimed in claim 1, wherein each of said infusions comprises a dosage of IL-2 of from 1.8 to 24 MU/day.
Claim 5
Dependent Claim
24 words
A method as claimed in claim 3, wherein said period of time of each of said infusions is on the order of 5 days.
Claim 6
Dependent Claim
23 words
A method as claimed in claim 1, further comprising administering zidovudine to said patient prior to or concomitantly with said administering of IL-2.