Patent US2357122A successfully refreshed from Google Patents.
Patent US5417975A successfully refreshed from Google Patents.
US5417975A
Expired / Lapsed
US
⏱️ 0.0 years remaining
Chemical Compound
Assignee: Ed Geistlich Soehne AG fuer Chemische Industrie
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Filing: 1994-01-04
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Granted: 1995-05-23
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Expires: 2014-01-04
Abstract
Abstract The invention provides a process for the preparation of high purity bone mineral wherein the organic matter in degreased bone is degraded and solubilized by heating with ammonia or a primary amine, characterized in that the solubilized degradation products are extracted by washing with flowing water at temperatures below 60° C., such heating with primary amine and washing steps optionally being repeated, whereby substantially all organic matter removable by these steps is removed, the bone mineral so treated being heated in air at temperatures of up to 700° C.
Inventors
- 👤 Heinz Lussi
- 👤 Peter Geistlich
Bibliographic Details
Application Number
—
Jurisdiction
US
Data Source
google_patents
Last Synchronized
2026-10-23 19:53
CPC Classifications
A; A61; A61L; A61L27/00; A61L27/36; A61L27/3604; A61L27/3608; A61L27/3641; A61L27/3645; A61L27/365; A61L27/3683; A61L27/3695; A61L27/50; A61L27/54; A61L2300/00; A61L2300/20; A61L2300/252; A61L2300/40; A61L2300/404; A61L2300/406; A61L2300/412; A61L2300/414; A61L2300/45; A61L2430/00; A61L2430/02; A61L2430/40; Y; Y10; Y10S; Y10S530/00; Y10S530/827; Y10S530/84
Claims Analysis
Total Claims: 5
Claim 1
Independent Claim
52 words
A bone mineral for use in medicine derived from natural bone and retaining substantially the original crystal structure and mineral microstructure of natural bone permitting physiologically controlled, cell mediated remodelling on implantation, while having an organic impurity content below 150 parts per million and a protein content below 135 parts per million.
Claim 2
Dependent Claim
52 words
A bone mineral for use in medicine derived from natural bone and retaining substantially the original crystal structure and mineral microstructure of natural bone permitting physiologically controlled, cell mediated remodelling on implantation, while having an organic impurity content below 150 parts per million and a protein content below 135 parts per million.
Claim 3
Dependent Claim
28 words
A bone mineral as claimed in claim 1 which has absorbed thereon a therapeutic amount of one or more antibiotics, sulphonamides or condensation products of formaldehyde and taurinamide.
Claim 4
Dependent Claim
29 words
A bone mineral as claimed in claim 1 or claim 2 having adsorbed thereon a therapeutic amount of one or more mitogenic, morphogenic, angiogenic factors and/or transforming growth factors.
Claim 5
Dependent Claim
39 words
A method of bone implantation or bone replacement, comprising forming a remodelling implant or a prosthetic bone replacement from bone mineral as claimed in claim 1, and surgically introducing the remodelling implant or prosthetic bone replacement into a patient.
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JPS5858041A
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EP0182483A1
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WO1986007265A1
Cited
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JPS63125258A
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DE8901347U1
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USPTO Annuity & Maintenance Windows
| Annuity Stage | Window Opens | Payment Deadline | Surcharge Period Until | Estimated Fee | Status |
|---|---|---|---|---|---|
| 3.5 Years (Year 4) | 1998-05-22 | 1998-11-21 | 1999-05-23 | $2000.00 | Window Closed / Lapsed |
| 7.5 Years (Year 8) | 2002-05-22 | 2002-11-21 | 2003-05-23 | $3760.00 | Window Closed / Lapsed |
| 11.5 Years (Year 12) | 2006-05-22 | 2006-11-21 | 2007-05-23 | $7700.00 | Window Closed / Lapsed |