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US5409940A
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3,4-dehydropiperidine derivatives
Assignee: Duphar International Research BV
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Filing: 1993-10-19
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Granted: 1995-04-25
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Expires: 2013-10-19
Abstract
Abstract The invention relates to a group of new 3,4-dehydropiperidine derivatives of the formula <IMAGE> wherein R1 is a hydrogen atom or an alkyl group having 1-3 carbon atoms; Y is a group of the general formula 2 <IMAGE> (2) wherein R2 is a group of the formula -(CH2)n-C(=X)-NR3R4, -(CH2)n-SO2-NR3R4, -(CH2)n-NR5-C(=X)-R6 or -(CH2)n-NR5-SO2-R6, wherein R3, R4 and R5 independent of each other represent hydrogen or alkyl (1-3C), R6 is alkyl (1-3C), X represents O or S; n is 0-4, and R is hydrogen or alkyl (1-3C). These compounds have interesting serotonin-1-like (partial) agonistic activity and can be used for the treatment of migraine.
Inventors
- 👤 Antonius Hulkenberg
- 👤 Karin J. van Charldorp
- 👤 Rolf van Hes
- 👤 Ineke VAN Wijngaarden
Bibliographic Details
Application Number
—
Jurisdiction
US
Data Source
google_patents
Last Synchronized
2026-11-07 15:04
CPC Classifications
C; C07; C07D; C07D409/00; C07D409/02; C07D409/04; A; A61; A61P; A61P25/00; A61P25/04
Claims Analysis
Total Claims: 4
Claim 1
Independent Claim
125 words
A 3,4-dehydropiperidine compound of the formula ##STR11## wherein R 1 is a hydrogen atom or an alkyl group having 1-3 carbon atoms; Y is a group of the formula 2 ##STR12## wherein R 2 is a group of the formula --(CH 2 ) n --C(═X)--NR 3 R 4 , --(CH 2 ) n --SO 2 --NR 3 R 4 , --(CH 2 ) n --NR 5 --C(═X)--R 6 or --(CH 2 ) n --NR 5 --SO 2 --R 6 , wherein R 3 , R 4 and R 5 independent of each other represent hydrogen or alkyl (1-3C), R 6 is alkyl (1-3C), X represents O or S; and n is 0-4; R is hydrogen or alkyl (1-3C), and a pharmaceutically acid addition salt thereof.
Claim 2
Dependent Claim
125 words
A 3,4-dehydropiperidine compound of the formula ##STR11## wherein R 1 is a hydrogen atom or an alkyl group having 1-3 carbon atoms; Y is a group of the formula 2 ##STR12## wherein R 2 is a group of the formula --(CH 2 ) n --C(═X)--NR 3 R 4 , --(CH 2 ) n --SO 2 --NR 3 R 4 , --(CH 2 ) n --NR 5 --C(═X)--R 6 or --(CH 2 ) n --NR 5 --SO 2 --R 6 , wherein R 3 , R 4 and R 5 independent of each other represent hydrogen or alkyl (1-3C), R 6 is alkyl (1-3C), X represents O or S; and n is 0-4; R is hydrogen or alkyl (1-3C), and a pharmaceutically acid addition salt thereof.
Claim 3
Dependent Claim
15 words
A pharmaceutical composition which comprises a 3,4-dehydropiperidine compound defined in claim 1 and a carrier.
Claim 4
Dependent Claim
28 words
A method of treating migraine in a human patient, said method comprising administering an antimigraine effective amount of a compound as claimed in claim 1 to the patient.
References Cited (Backward Citations)
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| 3.5 Years (Year 4) | 1998-04-24 | 1998-10-24 | 1999-04-25 | $2000.00 | Window Closed / Lapsed |
| 7.5 Years (Year 8) | 2002-04-24 | 2002-10-24 | 2003-04-25 | $3760.00 | Window Closed / Lapsed |
| 11.5 Years (Year 12) | 2006-04-24 | 2006-10-24 | 2007-04-25 | $7700.00 | Window Closed / Lapsed |