US5405607A
Expired / Lapsed
US
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Method for preparing fibrinogen adhesive from whole blood
Assignee: Baxter International Inc
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Filing: 1993-07-12
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Granted: 1995-04-11
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Expires: 2013-07-12
Abstract
Abstract A process and apparatus for one-step preparation of the fibrinogen component of an adhesive is described. The fibrinogen is precipitated directly from plasma using polyethylene glycol. This permits preparation of autologous fibrinogen from the patient during surgery which can be combined with calcium, ion and thrombin and used as an adhesive.
Inventors
- 👤 Gordon H. Epstein
Bibliographic Details
Application Number
—
Jurisdiction
US
Data Source
google_patents
Last Synchronized
2026-10-25 08:46
CPC Classifications
A; A61; A61B; A61B17/00; A61B17/00491; A61L; A61L24/00; A61L24/0005; A61L24/04; A61L24/10; A61L24/106; C; C07; C07K; C07K14/00; C07K14/435; C07K14/745; C07K14/75; A61B2017/00495; A61K; A61K38/00; Y; Y10; Y10S; Y10S435/00; Y10S435/81; Y10S604/00; Y10S604/902
Claims Analysis
Total Claims: 9
Claim 1
Independent Claim
58 words
A process for preparing a fibrinogen adhesive composition from whole blood which consists essentially of: contacting plasma, which has been removed from said whole blood, with an amount of polyethylene glycol (PEG) (MW200-8000 daltons) effective to precipitate said fibrinogen adhesive composition; recovering the precipitated fibrinogen adhesive composition; and suspending said precipitated fibrinogen adhesive composition in an aqueous medium.
Claim 2
Dependent Claim
58 words
A process for preparing a fibrinogen adhesive composition from whole blood which consists essentially of: contacting plasma, which has been removed from said whole blood, with an amount of polyethylene glycol (PEG) (MW200-8000 daltons) effective to precipitate said fibrinogen adhesive composition; recovering the precipitated fibrinogen adhesive composition; and suspending said precipitated fibrinogen adhesive composition in an aqueous medium.
Claim 3
Dependent Claim
18 words
The process of claim 1 wherein the plasma is prepared by centrifugation of whole blood treated with anticoagulant.
Claim 4
Dependent Claim
11 words
The process of claim 2 wherein the anticoagulant is citrate buffer.
Claim 5
Dependent Claim
15 words
The process of claim 1 wherein the PEG has a molecular weight of 1000-1500 daltons.
Claim 6
Dependent Claim
12 words
The process of claim 4 wherein said effective amount is 8-15% w/v.
Claim 7
Dependent Claim
15 words
The process of claim 1 wherein the precipitated fibrinogen adhesive composition is recovered by centrifugation.
Claim 8
Independent Claim
87 words
A method of cementing tissues with a fibrinogen adhesive comprising applying to said tissues an amount of said adhesive effective to cement said tissues, comprising thrombin, calcium ions, and a fibrinogen adhesive composition prepared from whole blood by a process consisting essentially of: contacting plasma, which has been removed from said whole blood, with an amount of polyethylene glycol (PEG) (MW 200-8000 daltons) effective to precipitate said fibrinogen adhesive composition; recovering the precipitated fibrinogen adhesive composition; and suspending said precipitated fibrinogen adhesive composition in an aqueous medium.
Claim 9
Independent Claim
87 words
A method of cementing tissues with a fibrinogen adhesive comprising applying to said tissues an amount of said adhesive effective to cement said tissues, comprising thrombin, calcium ions, and a fibrinogen adhesive composition prepared from whole blood by a process consisting essentially of: contacting plasma, which has been removed from said whole blood, with an amount of polyethylene glycol (PEG) (MW 200-8000 daltons) effective to precipitate said fibrinogen adhesive composition; recovering the precipitated fibrinogen adhesive composition; and suspending said precipitated fibrinogen adhesive composition in an aqueous medium.
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USPTO Annuity & Maintenance Windows
| Annuity Stage | Window Opens | Payment Deadline | Surcharge Period Until | Estimated Fee | Status |
|---|---|---|---|---|---|
| 3.5 Years (Year 4) | 1998-04-10 | 1998-10-10 | 1999-04-11 | $2000.00 | Window Closed / Lapsed |
| 7.5 Years (Year 8) | 2002-04-10 | 2002-10-10 | 2003-04-11 | $3760.00 | Window Closed / Lapsed |
| 11.5 Years (Year 12) | 2006-04-10 | 2006-10-10 | 2007-04-11 | $7700.00 | Window Closed / Lapsed |