US5403858A
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New compositions containing taxane derivatives
Assignee: Aventis Pharma SA
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Filing: 1992-07-03
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Granted: 1995-04-04
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Expires: 2012-07-03
Abstract
Abstract PCT No. PCT/FR92/00624 Sec. 371 Date Aug. 23, 1993 Sec. 102(e) Date Aug. 23, 1993 PCT Filed Jul. 3, 1992 PCT Pub. No. WO93/00928 PCT Pub. Date Jan. 21, 1993.Compositions containing taxane derivatives, consist of a solution of such derivative in a surfactant consisting of polysorbate, polyethelene glycol or hydrogenated castor oil. These compositions can be used to prepare perfusion solutions essentially free of ethanol.
Inventors
- 👤 Jean-Pierre Bastard
- 👤 Thierry Dupechez
- 👤 Jean-Louis Fabre
Bibliographic Details
Application Number
—
Jurisdiction
US
Data Source
google_patents
Last Synchronized
2026-10-27 09:57
CPC Classifications
A; A61; A61K; A61K31/00; A61K31/33; A61K31/335; A61K47/00; A61K47/06; A61K47/08; A61K47/10; A61K47/26; A61K47/44; A61K9/00; A61K9/0012; A61K9/0019; A61K9/08; A61P; A61P35/00; A61K9/0043
Claims Analysis
Total Claims: 19
Claim 1
Independent Claim
52 words
A composition consisting essentially of a compound of formula: ##STR2## in which R represents a hydrogen atom or an acetyl radical and R 1 represents a tert-butoxycarbonylamino or benzoylamino radical, dissolved in a surfactant selected from the group consisting of polysorbate, polyoxyethylene glycol and hydrogenated castor oil, and essentially free of ethanol.
Claim 2
Dependent Claim
52 words
A composition consisting essentially of a compound of formula: ##STR2## in which R represents a hydrogen atom or an acetyl radical and R 1 represents a tert-butoxycarbonylamino or benzoylamino radical, dissolved in a surfactant selected from the group consisting of polysorbate, polyoxyethylene glycol and hydrogenated castor oil, and essentially free of ethanol.
Claim 3
Dependent Claim
15 words
A composition according to claim 1, which contains less than 5% by volume of ethanol.
Claim 4
Dependent Claim
23 words
A composition according to claim 1, wherein, in the compound of formula (I), R represents hydrogen and R 1 represents a tert-butoxycarbonylamino radical.
Claim 5
Dependent Claim
25 words
A composition according to claim 1, wherein, in the compound of formula (I), R represents an acetyl group and R 1 represents a benzoyloxyamino radical.
Claim 6
Dependent Claim
17 words
A composition according to claim 1, which contains up to 200 mg/ml of compound of formula (I).
Claim 7
Dependent Claim
17 words
A composition according to claim 3, which contains 20 to 80 mg/ml of compound of formula (I).
Claim 8
Dependent Claim
17 words
A composition according to claim 4, which contains 6 to 20 mg/ml of compound of formula (I).
Claim 9
Dependent Claim
15 words
A composition according to claim 2, wherein the composition contains less than 2% of ethanol.
Claim 10
Dependent Claim
17 words
A composition according to claim 5, which contains up to 80 mg/ml of compound of formula (I).
Claim 11
Dependent Claim
57 words
Composition consisting essentially of a taxane derivative of the formula: ##STR3## in which R represents a hydrogen atom or an acetyl radical and R 1 represents a tert-butoxycarbonylamino or benzoylamino radical dissolved in a surfactant selected from the group consisting of polysorbate, polyoxyethylene glycol and hydrogenated castor oil, said composition containing less than 5% by volume ethanol.
Claim 12
Dependent Claim
57 words
Composition consisting essentially of a taxane derivative of the formula: ##STR3## in which R represents a hydrogen atom or an acetyl radical and R 1 represents a tert-butoxycarbonylamino or benzoylamino radical dissolved in a surfactant selected from the group consisting of polysorbate, polyoxyethylene glycol and hydrogenated castor oil, said composition containing less than 5% by volume ethanol.
Claim 13
Dependent Claim
13 words
Composition according to claim 10, wherein ethanol is less than 2% by volume.
Claim 14
Dependent Claim
28 words
A perfusion comprising less than 0.5 mg/ml of compound as defined in claim 3 and less than 1 ml/l of ethanol and less than 15 ml/l of surfactant.
Claim 15
Dependent Claim
21 words
A perfusion, comprising 1 mg/ml or less of compound as defined in claim 4 and less than 1 ml/l of ethanol.
Claim 16
Dependent Claim
31 words
A perfusion according to claim 12, wherein the perfusion contains 0.1 to 0.3 mg/ml of a compound of formula (I) wherein R represents hydrogen and R 1 represents a tert-butoxycarbonylamino radical.
Claim 17
Dependent Claim
27 words
A method for preparing a composition according to claim 1, which comprises dissolving a compound of formula (I) in ethanol, adding the surfactant and removing the ethanol.
Claim 18
Dependent Claim
33 words
A method for preparing a composition according to claim 1, which comprises slowly adding a compound of formula (I) to a solution of the surfactant containing 1 to 2% by volume of ethanol.
Claim 19
Dependent Claim
16 words
A method for preparing a composition according to claim 15, wherein ethanol is removed by evaporation.
References Cited (Backward Citations)
US4206221A
Cited
US4960790A
Cited
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