US5397572A
Expired / Lapsed
US
⏱️ 0.0 years remaining
Resorbable materials based on independently gelling polymers of a single enantiomeric lactide
Assignee: The University of Texas System
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Filing: 1993-12-02
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Granted: 1995-03-14
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Expires: 2013-12-02
Abstract
Abstract Resorbable materials and their preparation based on gelling a solution of a single polylactide enantiomer. The gel may be dried to produce solid materials, or may be extracted with a nonsolvent prior to drying to make microporous materials. Physical and mechanical properties of the material may be varied by varying the molecular weight of the gelling polymer, or by blending the gelling solution with other polymers or fillers. The resorbable materials can be used to make biodegradable implantation devices.
Inventors
- 👤 Allan G. A. Coombes
- 👤 James D. Heckman
- 👤 Barbara D. Boyan
Bibliographic Details
Application Number
—
Jurisdiction
US
Data Source
google_patents
Last Synchronized
2026-11-02 09:52
CPC Classifications
A; A61; A61F; A61F2/00; A61F2/02; A61F2/28; A61L; A61L27/00; A61L27/14; A61L27/18; A61L27/50; A61L27/58; C; C08; C08J; C08J9/00; C08J9/28; A61F2/30; A61F2/3094; A61F2002/2835; A61F2002/30001; A61F2002/30003; A61F2002/30004; A61F2002/3006; A61F2002/30062; A61F2002/30065; A61F2002/30108; A61F2002/3011; A61F2002/30112; A61F2002/30113; A61F2002/30199; A61F2002/302; A61F2002/30224; A61F2002/30225; A61F2002/30667; A61F2002/30677; A61F2/30767; A61F2/30771; A61F2002/30772; A61F2002/30784; A61F2002/30785; A61F2210/00; A61F2210/0004; A61F2210/0071; A61F2230/00; A61F2230/0002; A61F2230/0004; A61F2230/0006; A61F2230/0063; A61F2230/0065; A61F2230/0069; A61F2250/00; A61F2250/0014; C08J2367/00; C08J2367/04; Y; Y10; Y10T; Y10T428/00; Y10T428/249921; Y10T428/249953; Y10T428/249978; Y10T428/249979
Claims Analysis
Total Claims: 21
Claim 1
Independent Claim
55 words
A resorable implantation device comprising a dried gel, the dried gel being formed from cooling a polymer solution comprising an independently-gelling polymer of a single enantiomeric lactide dissolved in a solvent to form a gel capable of substantially retaining a molded shape upon handling thereof, and drying the gel to form the resorbable implantation device.
Claim 2
Dependent Claim
55 words
A resorable implantation device comprising a dried gel, the dried gel being formed from cooling a polymer solution comprising an independently-gelling polymer of a single enantiomeric lactide dissolved in a solvent to form a gel capable of substantially retaining a molded shape upon handling thereof, and drying the gel to form the resorbable implantation device.
Claim 3
Dependent Claim
70 words
A resorbable implantation device comprising a dried microporous material, the dried microporous material being formed from cooling a polymer solution comprising an independently-gelling polymer of a single enantiomeric lactide dissolved in a solvent to form a gel capable of substantially retaining a molded shape upon handling thereof, extracting the solvent with a nonsolvent to precipitate out the microporous material, and drying the microporous material to form the resorbable implantation device.
Claim 4
Dependent Claim
70 words
A resorbable implantation device comprising a dried microporous material, the dried microporous material being formed from cooling a polymer solution comprising an independently-gelling polymer of a single enantiomeric lactide dissolved in a solvent to form a gel capable of substantially retaining a molded shape upon handling thereof, extracting the solvent with a nonsolvent to precipitate out the microporous material, and drying the microporous material to form the resorbable implantation device.
Claim 5
Dependent Claim
17 words
The resorbable implantation device of claim 1 which includes a second material incorporated within the dried gel.
Claim 6
Dependent Claim
18 words
The resorbable implantation device of claim 2 which includes a second material incorporated within the dried microporous material.
Claim 7
Dependent Claim
16 words
The resorbable implantation device of claim 3 or 4, wherein the second material comprises a polymer.
Claim 8
Dependent Claim
41 words
The resorbable implantation device of claim 5, wherein the second polymer comprises a polymer of an alpha-hydroxy acid, a polymer of a lactone, a copolymer of at least one alpha-hydroxy acid, a polyethylene oxide, or a copolymer containing a thermoplastic elastomer.
Claim 9
Dependent Claim
17 words
The resorbable implantation device of claim 1 which includes a filler material incorporated within the dried gel.
Claim 10
Dependent Claim
18 words
The resorbable implantation device of claim 2 which includes a filler material incorporated within the dried microporous material.
Claim 11
Dependent Claim
16 words
The resorbable implantation device of claim 1 or 2, wherein the single enantiomeric lactide is L-lactide.
Claim 12
Dependent Claim
14 words
The resorbable implantation device of claim 1 or 2, wherein the polymer is poly(L-lactide).
Claim 13
Dependent Claim
16 words
The resorbable implantation device of claim 1 or 2, wherein the single enantiomeric lactide is D-lactide.
Claim 14
Dependent Claim
14 words
The resorbable implantation device of claim 1 or 2, wherein the polymer is poly(D-lactide).
Claim 15
Dependent Claim
20 words
The resorbable implantation device of claim 1 or 2 which has a minimum thickness of at least about 2 mm.
Claim 16
Dependent Claim
20 words
The resorbable implantation device of claim 1 or 2 which has a minimum thickness of at least about 5 mm.
Claim 17
Dependent Claim
20 words
The resorbable implantation device of claim 1 or 2 which has a minimum thickness of at least about 10 mm.
Claim 18
Dependent Claim
14 words
The resorbable implantation device of claim 1 or 2 which has a honeycomb structure.
Claim 19
Dependent Claim
17 words
The resorbable implantation device of claim 1 or 2, wherein the solvent is acetone or ethyl acetate.
Claim 20
Dependent Claim
16 words
The resorable implantation device of claim 1 or 2 which includes at least one bore therein.
Claim 21
Dependent Claim
16 words
The resorable implantation device of claim 1 or 2 which includes a bioactive material incorporated therein.
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USPTO Annuity & Maintenance Windows
| Annuity Stage | Window Opens | Payment Deadline | Surcharge Period Until | Estimated Fee | Status |
|---|---|---|---|---|---|
| 3.5 Years (Year 4) | 1998-03-13 | 1998-09-12 | 1999-03-14 | $2000.00 | Window Closed / Lapsed |
| 7.5 Years (Year 8) | 2002-03-13 | 2002-09-12 | 2003-03-14 | $3760.00 | Window Closed / Lapsed |
| 11.5 Years (Year 12) | 2006-03-13 | 2006-09-12 | 2007-03-14 | $7700.00 | Window Closed / Lapsed |