US5383848A
Expired / Lapsed
US
⏱️ 0.0 years remaining
Iontophoretic administration of drugs
Assignee: Sicor Inc
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Filing: 1991-04-04
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Granted: 1995-01-24
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Expires: 2011-04-04
Abstract
Abstract Methods, formulations, and a system for improved iontophoretic administration of a drug, by, preferably, topical administration of a formulation containing an active vasodilator, rubefacient, or counterirritant agent such as capsaicin on the skin at the electrode site, or, iontophoretic administration of a vasodilator formulation or alpha blocker prior to iontophoretic administration of the drug.
Inventors
- 👤 Robert S. Hillman
- 👤 John M. Pawelchak
Bibliographic Details
Application Number
—
Jurisdiction
US
Data Source
google_patents
Last Synchronized
2026-11-05 18:05
CPC Classifications
A; A61; A61K; A61K45/00; A61K45/06; A61K31/00; A61K31/33; A61K31/395; A61K31/41; A61K31/415; A61K31/435; A61K31/44; A61K31/455; A61K31/60; A61K31/618; A61K31/621; A61K36/00; A61K36/18; A61K36/185; A61K36/81; A61K9/00; A61K9/0002; A61K9/0009
Claims Analysis
Total Claims: 12
Claim 1
Independent Claim
155 words
An improved method of iontophoretic administration of a drug to a subject comprising the steps of: selecting a site on the subject's skin for iontophoretic administration of the drug; administering a formulation capable of increasing blood flow to the subject's skin near the site and prior to iontophoretic administration of the drug; allowing sufficient time to pass for the formulation to effect increased flow of blood in the skin near the site on the subject's skin; and iontophoretically administering the drug to the subject at the site; wherein said formulation includes from about 0.1 to about 5% methyl nicotinate and from about 0.02% to about 0.3% capsaicin in a vehicle of which comprises a short chain aliphatic alcohol, light mineral oil or propylene glycol and methyl salicylate, in a ratio which comprises about 2 to about 6 parts alcohol and about 1 to about 4 parts mineral oil or propylene glycol per part methyl salicylate.
Claim 2
Dependent Claim
155 words
An improved method of iontophoretic administration of a drug to a subject comprising the steps of: selecting a site on the subject's skin for iontophoretic administration of the drug; administering a formulation capable of increasing blood flow to the subject's skin near the site and prior to iontophoretic administration of the drug; allowing sufficient time to pass for the formulation to effect increased flow of blood in the skin near the site on the subject's skin; and iontophoretically administering the drug to the subject at the site; wherein said formulation includes from about 0.1 to about 5% methyl nicotinate and from about 0.02% to about 0.3% capsaicin in a vehicle of which comprises a short chain aliphatic alcohol, light mineral oil or propylene glycol and methyl salicylate, in a ratio which comprises about 2 to about 6 parts alcohol and about 1 to about 4 parts mineral oil or propylene glycol per part methyl salicylate.
Claim 3
Dependent Claim
23 words
A method according to claim 1 wherein said vehicle comprises 2.9 parts ethyl alcohol and 2.0 parts propylene glycol per part methyl salicylate.
Claim 4
Dependent Claim
19 words
The method according to claim 2 wherein said formulation comprises about 0.27% (w/w) methyl nicotinate and about 0.028% capsaicin.
Claim 5
Dependent Claim
23 words
A method according to claim 1 wherein said vehicle comprises 2.9 parts isopropyl alcohol and 2.0 parts mineral oil per part methyl salicylate.
Claim 6
Dependent Claim
17 words
The method according to claim 4 wherein said formulation comprises 0.27% (w/w) methyl nicotinate and 0.028% capsaicin.
Claim 7
Dependent Claim
114 words
An improved method of iontophoretic administration of a drug to a subject comprising the steps of: selecting a site on the subject's skin for iontophoretic administration of the drug; administering a formulation capable of increasing blood flow to the subject's skin near the site and prior to iontophoretic administration of the drug; allowing sufficient time to pass for the formulation to effect increased flow of blood in the skin near the side on the subject's skin; and iontophoretically administering the drug to the subject at the site; wherein said formulation contains methyl salicylate, 17.5%; histamine dihydrochloride, 0.02%; methyl ester of nicotinic acid, 0.27%; and capsicum oleoresin, 0.24% in an isopropyl alcohol and water vehicle.
Claim 8
Dependent Claim
114 words
An improved method of iontophoretic administration of a drug to a subject comprising the steps of: selecting a site on the subject's skin for iontophoretic administration of the drug; administering a formulation capable of increasing blood flow to the subject's skin near the site and prior to iontophoretic administration of the drug; allowing sufficient time to pass for the formulation to effect increased flow of blood in the skin near the side on the subject's skin; and iontophoretically administering the drug to the subject at the site; wherein said formulation contains methyl salicylate, 17.5%; histamine dihydrochloride, 0.02%; methyl ester of nicotinic acid, 0.27%; and capsicum oleoresin, 0.24% in an isopropyl alcohol and water vehicle.
Claim 9
Dependent Claim
104 words
An improved method of iontophoretic administration of a drug to a subject comprising the steps of: selecting a site on the subject's skin for iontophoretic administration of the drug; administering a formulation capable of increasing blood flow to the subject's skin near the site and prior to iontophoretic administration of the drug; allowing sufficient time to pass for the formulation to effect increased flow of blood in the skin near the side on the subject's skin; and iontophoretically administering the drug to the subject at the site; wherein said formulation contains methyl salicylate, 15%; capsaicin, 0.025%; and camphor, 3.6% in 70% alcohol with acetone.
Claim 10
Dependent Claim
104 words
An improved method of iontophoretic administration of a drug to a subject comprising the steps of: selecting a site on the subject's skin for iontophoretic administration of the drug; administering a formulation capable of increasing blood flow to the subject's skin near the site and prior to iontophoretic administration of the drug; allowing sufficient time to pass for the formulation to effect increased flow of blood in the skin near the side on the subject's skin; and iontophoretically administering the drug to the subject at the site; wherein said formulation contains methyl salicylate, 15%; capsaicin, 0.025%; and camphor, 3.6% in 70% alcohol with acetone.
Claim 11
Dependent Claim
99 words
An improved method of iontophoretic administration of a drug to a subject comprising the steps of: selecting a site on the subject's skin for iontophoretic administration of the drug; administering a formulation capable of increasing blood flow to the subject's skin near the site and prior to iontophoretic administration of the drug; allowing sufficient time to pass for the formulation to effect increased flow of blood in the skin near the side on the subject's skin; and iontophoretically administering the drug to the subject at the site; wherein said formulation includes 0.24% capsaicin and 0.27% methyl nicotinate by weight.
Claim 12
Dependent Claim
99 words
An improved method of iontophoretic administration of a drug to a subject comprising the steps of: selecting a site on the subject's skin for iontophoretic administration of the drug; administering a formulation capable of increasing blood flow to the subject's skin near the site and prior to iontophoretic administration of the drug; allowing sufficient time to pass for the formulation to effect increased flow of blood in the skin near the side on the subject's skin; and iontophoretically administering the drug to the subject at the site; wherein said formulation includes 0.24% capsaicin and 0.27% methyl nicotinate by weight.
References Cited (Backward Citations)
USPTO Annuity & Maintenance Windows
| Annuity Stage | Window Opens | Payment Deadline | Surcharge Period Until | Estimated Fee | Status |
|---|---|---|---|---|---|
| 3.5 Years (Year 4) | 1998-01-23 | 1998-07-25 | 1999-01-24 | $2000.00 | Window Closed / Lapsed |
| 7.5 Years (Year 8) | 2002-01-23 | 2002-07-25 | 2003-01-24 | $3760.00 | Window Closed / Lapsed |
| 11.5 Years (Year 12) | 2006-01-23 | 2006-07-25 | 2007-01-24 | $7700.00 | Window Closed / Lapsed |