Imidazolin-2-ones
Abstract
Abstract A compound having the formula: ##STR1## wherein R, R 1 and R 2 are independently selected from hydrogen; hydroxy; fluorine; bromine; chlorine; C 1 -C 20 alkyl; C 2 -C 20 alkenyl; C 2 -C 20 alkynyl; C 3 -C 10 cycloalkyl; C 2 -C 20 (monohydroxy or polyhydroxy)alkyl; C 1 -C 20 (monohalo or polyhalo)alkyl; carboxy; C 1 -C 20 alkylcarboxy; C 1 -C 20 alkenylcarboxy; C 1 -C 20 carboxyalkyl; C 1 -C 20 alkanoyl; C 1 -C 20 alkanoyloxy; C 1 -C 20 alkoxycarbonyl; carbamoyl; carbamyl; C 1 -C 20 alkylcarbamyl; sulfo; C 1 -C 20 alkylsulfonyl; C 1 -C 20 alkylsulfinyl; C 1 -C 20 alkylsulfoxide; C 1 -C 20 alkylsulfone; thio; C 1 -C 20 alkylthio; amino; nitro; C 1 -C 20 alkylamino; C 1 -C 20 aminoalkyl; substituted or unsubstituted phenyl or benzyl, the substituents being selected from hydroxy, fluorine, bromine, chlorine, C 1 -C 20 alkyl, C 2 -C 20 alkenyl, C 2 -C 20 (monohydroxy or polyhydroxy)alkyl, X is methyl or oxygen and n is 0 to 20. The invention is also directed to a method for increasing the topical penetration of a physiologically active agent across the skin or membrane of a mammalian organism. Also claimed is a pharmaceutical composition and a novel method for preparing 1-substituted-4-imidazolin-2-one.
Inventors
- 👤 Takeru Higuchi, deceased
- 👤 co-executor by Kenji W. Higuchi
- 👤 Ooi Wong
Bibliographic Details
Claims Analysis
Total Claims: 7References Cited (Backward Citations)
USPTO Annuity & Maintenance Windows
| Annuity Stage | Window Opens | Payment Deadline | Surcharge Period Until | Estimated Fee | Status |
|---|---|---|---|---|---|
| 3.5 Years (Year 4) | 1992-07-03 | 1993-01-02 | 1993-07-04 | $2000.00 | Window Closed / Lapsed |
| 7.5 Years (Year 8) | 1996-07-03 | 1997-01-02 | 1997-07-04 | $3760.00 | Window Closed / Lapsed |
| 11.5 Years (Year 12) | 2000-07-03 | 2001-01-02 | 2001-07-04 | $7700.00 | Window Closed / Lapsed |