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US5382523A
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Use of sparingly soluble salt of a heteropoly acid for the determination of an analyte, a corresponding method of determination as well as a suitable agent thereof
Assignee: Roche Diagnostics GmbH
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Filing: 1993-04-13
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Granted: 1995-01-17
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Expires: 2013-04-13
Abstract
Abstract A sparingly soluble salt of a heteropoly acid is used for the determination of an analyte which is an aromatic amine rich in electrons or together with another substance leads to such an amine. The analyte is determined by means of the heteropoly blue color formed.
Inventors
- 👤 Joachim Hoenes
- 👤 Hans Wielinger
- 👤 Volker Unkrig
Bibliographic Details
Application Number
—
Jurisdiction
US
Data Source
google_patents
Last Synchronized
2026-11-04 22:35
CPC Classifications
G; G01; G01N; G01N33/00; G01N33/48; G01N33/50; C; C12; C12Q; C12Q1/00; C12Q1/26; C12Q1/34; C12Q1/48; G01N33/52; G01N33/525; Y; Y10; Y10T; Y10T436/00; Y10T436/17; Y10T436/173845; Y10T436/174614; Y10T436/175383
Claims Analysis
Total Claims: 9
Claim 1
Independent Claim
67 words
A reagent for the determination of an analyte comprising: a substance or substances capable of reacting with the analyte to form an organic amine which is a stronger reducing agent than aniline, and a sparingly soluble salt of a heteropoly acid which forms heteropoly blue with the organic amines wherein the cation of the sparingly soluble salt of the heteropoly acid is larger than NH 4 +.
Claim 2
Dependent Claim
67 words
A reagent for the determination of an analyte comprising: a substance or substances capable of reacting with the analyte to form an organic amine which is a stronger reducing agent than aniline, and a sparingly soluble salt of a heteropoly acid which forms heteropoly blue with the organic amines wherein the cation of the sparingly soluble salt of the heteropoly acid is larger than NH 4 +.
Claim 3
Dependent Claim
36 words
A reagent according to claim 1, wherein the heteropoly acid is a heteropoly acid of molybdenum, molybdenum and tungsten, vanadium and molybdenum or vanadium, molybdenum and tungsten with phosphorus, arsenic, silicon or germanium as the heteroatoms.
Claim 4
Dependent Claim
15 words
A reagent according to claim 2, wherein the heteropoly acid of molybdenum is 18-molybdodiphosphoric acid.
Claim 5
Dependent Claim
92 words
A reagent according to claim 1, wherein the cation is the formula R 1 R 2 R 3 R 4 X + in which R 1 , R 2 , R 3 and R 4 are the same or different and denote hydrogen, or an alkyl, aryl or aralkyl residue, with the proviso that all of R 1 , R 2 , R 3 and R 4 are not hydrogen, or two alkyl residues may be taken together to form an alkylene residue, and X represents a phosphorus or a nitrogen atom.
Claim 6
Dependent Claim
12 words
A reagent according to claim 4, wherein X is a nitrogen atom.
Claim 7
Dependent Claim
153 words
A reagent according to claim 1 wherein the amine has the formula II ##STR2## in which R 5 denotes hydroxy or amino, in which the amino group is optionally substituted once or twice by an alkyl residue, and the alkyl residue is itself optionally substituted by a hydroxy group, an amino group optionally substituted once or twice by alkyl, PO 3 H 2 , SO 3 H or CO 2 H, and R 6 and R 7 which are both the same or different and represent hydrogen or alkyl, in which the alkyl residue is optionally substituted by a hydroxy group, an amino group optionally substituted once or twice by alkyl, PO 3 H 2 , SO 3 H or CO 2 H, and R 8 , R 9 , R 10 and R 11 are the same or different and denote hydrogen, alkyl, alkoxy, alkylthio, aryloxy, arylthio, halogen, carboxy, carboxyalkyl or alkoxycarbonyl.
Claim 8
Dependent Claim
11 words
A reagent according to claim 1 which is in a solution.
Claim 9
Dependent Claim
11 words
A reagent according to claim 1 which is on a carrier.
References Cited (Backward Citations)
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| 3.5 Years (Year 4) | 1998-01-16 | 1998-07-18 | 1999-01-17 | $2000.00 | Window Closed / Lapsed |
| 7.5 Years (Year 8) | 2002-01-16 | 2002-07-18 | 2003-01-17 | $3760.00 | Window Closed / Lapsed |
| 11.5 Years (Year 12) | 2006-01-16 | 2006-07-18 | 2007-01-17 | $7700.00 | Window Closed / Lapsed |