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US5376361A
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Method and compositions for topical application to the skin for prevention and/or treatment of radiation-induced skin damage
Assignee: NV Perricone LLC
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Filing: 1993-01-13
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Granted: 1994-12-27
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Expires: 2013-01-13
Abstract
Abstract A method for the prevention and/or treatment of radiation-induced skin damage, particularly ultraviolet-induced skin burn (e.g., sunburn), in which a tocotrienol, a derivative thereof or a vitamin E preparation enriched with tocotrienol or a tocotrienol derivative, is topically applied to the exposed or affected skin areas. A fat-soluble fatty acid ester of ascorbic acid such as palmityl ascorbate is preferably applied with the tocotrienol in association with a dermatologically acceptable carrier. Tocotrienol augments the efficacy of sunscreens containing compounds that reduce penetration of or absorb ultraviolet radiation.
Inventors
- 👤 Nicholas V. Perricone
Bibliographic Details
Application Number
—
Jurisdiction
US
Data Source
google_patents
Last Synchronized
2026-11-09 15:35
CPC Classifications
A; A61; A61K; A61K8/00; A61K8/18; A61K8/30; A61K8/49; A61K8/4973; A61K8/498; A61K31/00; A61K31/33; A61K31/335; A61K31/35; A61K31/352; A61K31/353; A61K31/355; A61K31/60; A61K8/67; A61K8/676; A61K8/678; A61Q; A61Q17/00; A61Q17/04
Claims Analysis
Total Claims: 23
Claim 1
Independent Claim
40 words
A method for preventing radiation-induced skin damage, said method comprising topically applying to skin areas subject to such damage an effective amount of an active ingredient selected from the group consisting of tocotrienols and vitamin E preparations enriched with tocotrienols.
Claim 2
Independent Claim
40 words
A method for preventing radiation-induced skin damage, said method comprising topically applying to skin areas subject to such damage an effective amount of an active ingredient selected from the group consisting of tocotrienols and vitamin E preparations enriched with tocotrienols.
Claim 3
Dependent Claim
24 words
A method according to claim 1 wherein the active ingredient is a tocotrienol selected from the group consisting of alpha-tocotrienol, beta-tocotrienol, gamma-tocotrienol, and delta-tocotrienol.
Claim 4
Dependent Claim
19 words
A method according to claim 1 wherein said effective amount is applied as a composition further comprising a reductant.
Claim 5
Dependent Claim
18 words
A method according to claim 3 wherein said reductant is a fat-soluble fatty acid ester of ascorbic acid.
Claim 6
Dependent Claim
33 words
A method according to claim 4 wherein said fat-soluble fatty acid ester of ascorbic acid is selected from the group consisting of ascorbyl palmitate, ascorbyl laurate, ascorbyl myristate, ascorbyl stearate, and mixtures thereof.
Claim 7
Dependent Claim
18 words
A method according to claim 5 wherein said fat-soluble fatty acid ester of ascorbic acid is ascorbyl palmitate.
Claim 8
Dependent Claim
25 words
A method according to claim 1 wherein said active compound is applied in the form of a sunscreen composition further comprising a dermatologically acceptable carrier.
Claim 9
Dependent Claim
21 words
A method according to claim 7 wherein the sunscreen composition contains a compound that reduces penetration of or absorbs ultraviolet radiation.
Claim 10
Dependent Claim
41 words
A method according to claim 8 wherein the compound that reduces penetration of or absorbs ultraviolet radiation is selected from the group consisting of para-aminobenzoic acid, para-aminobenzoic acid esters, cinnamates, benzophenone, anthranilate, titanium dioxide, zinc oxide, iron oxide, and mixtures thereof.
Claim 11
Dependent Claim
33 words
A method according to claim 7 wherein the combination of the compound and the carrier is in a form selected from the group consisting of solutions, dispersions, creams, lotions, gels and solid sticks.
Claim 12
Dependent Claim
18 words
A method according to claim 7 wherein the combination comprises about 0.5% to about 5% by weight tocotrienol.
Claim 13
Independent Claim
50 words
A method for the treatment of radiation-induced skin damage, said treatment comprising topically applying to the affected skin areas an effective amount of a composition comprised of a dermatologically acceptable carrier and a tocotrienol composition selected from the group consisting of tocotrienols, and a vitamin E preparation enriched with tocotrienols.
Claim 14
Independent Claim
50 words
A method for the treatment of radiation-induced skin damage, said treatment comprising topically applying to the affected skin areas an effective amount of a composition comprised of a dermatologically acceptable carrier and a tocotrienol composition selected from the group consisting of tocotrienols, and a vitamin E preparation enriched with tocotrienols.
Claim 15
Dependent Claim
36 words
A method according to claim 12 wherein the composition further comprises a fat-soluble fatty acid ester of ascorbic acid selected from the group consisting of ascorbyl palmitate, ascorbyl laurate, ascorbyl myristate, ascorbyl stearate, and mixtures thereof.
Claim 16
Dependent Claim
21 words
A method according to claim 12 wherein the tocotrienol is selected from the group consisting of alpha-tocotrienol, beta-tocotrienol, gamma-tocotrienol, and delta-tocotrienol.
Claim 17
Dependent Claim
11 words
A method according to claim 14 wherein the tocotrienol is alpha-tocotrienol.
Claim 18
Dependent Claim
51 words
In a sunscreen composition comprising a compound that reduces penetration of or absorbs ultraviolet radiation and a dermatologically acceptable carrier, an improvement wherein, to augment the efficacy of the sunscreen, said composition further comprises a tocotrienol composition selected from the group consisting of tocotrienols and vitamin E preparations enriched with tocotrienols.
Claim 19
Dependent Claim
51 words
In a sunscreen composition comprising a compound that reduces penetration of or absorbs ultraviolet radiation and a dermatologically acceptable carrier, an improvement wherein, to augment the efficacy of the sunscreen, said composition further comprises a tocotrienol composition selected from the group consisting of tocotrienols and vitamin E preparations enriched with tocotrienols.
Claim 20
Dependent Claim
21 words
An improvement according to claim 16 wherein said tocotrienol is selected from the group consisting of alpha-tocotrienol, beta-tocotrienol, gamma-tocotrienol, and delta-tocotrienol.
Claim 21
Dependent Claim
41 words
An improvement according to claim 16 wherein the compound that reduces penetration of or absorbs ultraviolet radiation is selected from .the group consisting of para-aminobenzoic acid, para-aminobenzoic acid esters, cinnamates, benzophenone, anthranilate, titanium dioxide, zinc oxide, iron oxide, and mixtures thereof.
Claim 22
Dependent Claim
36 words
An improvement according to claim 16 wherein the composition further comprises a fat-soluble fatty acid ester of ascorbic acid selected from the group consisting of ascorbyl palmitate, ascorbyl laurate, ascorbyl myristate, ascorbyl stearate, and mixtures thereof.
Claim 23
Dependent Claim
11 words
An improvement according to claim 19 wherein said tocotrienol is D-alpha-tocotrienol.
References Cited (Backward Citations)
DE2000507A1
Cited
ZA756475B
Cited
JPS5261239A
Cited
US4975272A
Cited
US4695452A
Cited
JPS61152613A
Cited
US4983382A
Cited
EP0291960A2
Cited
EP0337464A2
Cited
US4938969A
Cited
USPTO Annuity & Maintenance Windows
| Annuity Stage | Window Opens | Payment Deadline | Surcharge Period Until | Estimated Fee | Status |
|---|---|---|---|---|---|
| 3.5 Years (Year 4) | 1997-12-26 | 1998-06-27 | 1998-12-27 | $2000.00 | Window Closed / Lapsed |
| 7.5 Years (Year 8) | 2001-12-26 | 2002-06-27 | 2002-12-27 | $3760.00 | Window Closed / Lapsed |
| 11.5 Years (Year 12) | 2005-12-26 | 2006-06-27 | 2006-12-27 | $7700.00 | Window Closed / Lapsed |