Patent US5362734A successfully refreshed from Google Patents.
US5362734A
Expired / Lapsed
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Certain benzo-quinolizine compounds and derivatives thereof
Assignee: Wyeth LLC
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Filing: 1993-02-18
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Granted: 1994-11-08
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Expires: 2013-02-18
Abstract
Abstract Compounds of formula ##STR1## wherein R 1 is hydrogen or one or more specified substituents, X is --O-- or --NR 2 -- where R 2 is lower alkyl, lower alkenyl, lower alkynyl, aryl or specified substituted lower alkyl or R 2 represents a group --Z-- which is connected to the 8-position of the aromatic ring so as to form a heterocyclic ring of 5 to 7 ring members, Y is O or NR 3 where R 3 is hydrogen or lower alkyl, and B is a saturated azabicyclic ring (e.g. tropanyl or quinuclidinyl) or a N-oxide thereof and their acid addition salts are 5-HT 3 antagonists which may be used in, for example, the treatment of neuro-psychiatric disorders.
Inventors
- 👤 Terence J. Ward
- 👤 Janet C. White
Bibliographic Details
Application Number
—
Jurisdiction
US
Data Source
google_patents
Last Synchronized
2026-11-05 15:06
CPC Classifications
C; C07; C07D; C07D451/00; C07D451/02; C07D451/04; A; A61; A61P; A61P1/00; A61P1/08; A61P25/00; A61P25/18; A61P43/00; C07D451/14
Claims Analysis
Total Claims: 5
Claim 1
Independent Claim
134 words
A compound of the formula ##STR13## or a pharmaceutically acceptable acid addition salt thereof, in which R 1 represents hydrogen or one or more substituents selected from lower alkyl, hydroxy, lower alkoxy, halogen, methylenedioxy, halo(lower)alkyl, nitro, amino, (lower)alkylamino and di(lower)alkylamino X represents a group of formula --Z-- which is connected to the 8-position of the aromatic ting so as to form a heterocyclic ring of 5-6 ting members wherein the ring members represented by Z are two or three methylene groups optionally substituted by one or more lower alkyl groups and the X position of the --Z-- chain is N; Y represents 0 or NR 3 where R 3 is hydrogen or lower alkyl and B represents a saturated azabicyclic ring, or an N-oxide thereof, wherein the saturated azabicyclic ting has the formula ##STR14##
Claim 2
Dependent Claim
134 words
A compound of the formula ##STR13## or a pharmaceutically acceptable acid addition salt thereof, in which R 1 represents hydrogen or one or more substituents selected from lower alkyl, hydroxy, lower alkoxy, halogen, methylenedioxy, halo(lower)alkyl, nitro, amino, (lower)alkylamino and di(lower)alkylamino X represents a group of formula --Z-- which is connected to the 8-position of the aromatic ting so as to form a heterocyclic ring of 5-6 ting members wherein the ring members represented by Z are two or three methylene groups optionally substituted by one or more lower alkyl groups and the X position of the --Z-- chain is N; Y represents 0 or NR 3 where R 3 is hydrogen or lower alkyl and B represents a saturated azabicyclic ring, or an N-oxide thereof, wherein the saturated azabicyclic ting has the formula ##STR14##
Claim 3
Dependent Claim
73 words
A compound as claimed in claim 1 which has the formula ##STR15## or a pharmaceutically acceptable acid addition salt thereof, in which R 1 , B and Y have the meanings given in claim 1 and Z is --(CH 2 ) n -- where n is 2 or 3, an alkyl substituted di- or tri-methylene chain, --OCH 2 --, --OC(lower alkyl) 2 --, --S--CH 2 CH 2 or --CH 2 OCH 2 --.
Claim 4
Dependent Claim
23 words
A compound as claimed in claim 2 wherein Z is --CH 2 CH 2 -- or --CH 2 CH 2 CH 2 --.
Claim 5
Dependent Claim
21 words
A pharmaceutical composition comprising an effective amount of a compound claimed in claim 1 in association with a pharmaceutically acceptable carrier.
References Cited (Backward Citations)
WO1984000381A1
Cited
GB2145416A
Cited
EP0200444A2
Cited
DE3827253A1
Cited
EP0382687A2
Cited
US5096901A
Cited
US5225419A
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USPTO Annuity & Maintenance Windows
| Annuity Stage | Window Opens | Payment Deadline | Surcharge Period Until | Estimated Fee | Status |
|---|---|---|---|---|---|
| 3.5 Years (Year 4) | 1997-11-07 | 1998-05-09 | 1998-11-08 | $2000.00 | Window Closed / Lapsed |
| 7.5 Years (Year 8) | 2001-11-07 | 2002-05-09 | 2002-11-08 | $3760.00 | Window Closed / Lapsed |
| 11.5 Years (Year 12) | 2005-11-07 | 2006-05-09 | 2006-11-08 | $7700.00 | Window Closed / Lapsed |