Patent US5360610A successfully refreshed from Google Patents.
US5360610A
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US
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Method for stimulating nerve fiber growth
Assignee: Surmodics SMP Inc
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Filing: 1993-03-15
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Granted: 1994-11-01
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Expires: 2013-03-15
Abstract
Abstract The present invention relates to polymeric microspheres as injectable, drug-delivery systems for use to deliver bioactive agents to sites within the central nervous system, and for the stimulation of nerve fiber growth by implanting such microspheres within the central nervous system of a patient.
Inventors
- 👤 Thomas R. Tice
- 👤 Deborah L. Dillon
- 👤 David W. Mason
- 👤 Amanda McRae-McFarlane
- 👤 Annica B. Dahlstrom
Bibliographic Details
Application Number
—
Jurisdiction
US
Data Source
google_patents
Last Synchronized
2026-10-24 20:40
CPC Classifications
A; A61; A61K; A61K31/00; A61K31/13; A61K31/135; A61K9/00; A61K9/0012; A61K9/0085; A61K9/14; A61K9/16; A61K9/1605; A61K9/1629; A61K9/1641; A61K9/1647; A61P; A61P25/00; A61P25/08; A61P25/14; A61P25/16; A61P25/28
Claims Analysis
Total Claims: 12
Claim 1
Independent Claim
43 words
A method for eliciting neural fiber growth within the central nervous system which comprises implanting within the central nervous system a neuro-active neural fiber growth eliciting molecule encapsulated within a microsphere comprising the copolymer of poly(lactide-co-glycolide) or a homopolymer of polylactide or polyglycolide.
Claim 2
Independent Claim
43 words
A method for eliciting neural fiber growth within the central nervous system which comprises implanting within the central nervous system a neuro-active neural fiber growth eliciting molecule encapsulated within a microsphere comprising the copolymer of poly(lactide-co-glycolide) or a homopolymer of polylactide or polyglycolide.
Claim 3
Dependent Claim
37 words
A method according to claim 1 wherein the microsphere is selected from a group consisting of particles having the neuro-active molecule centrally located within a polymeric membrane, or an matrix structure of neuro-active molecule and polymeric excipient.
Claim 4
Dependent Claim
22 words
A method according to claim 1 wherein the microspheres are spherical particles of from about 5 to about 45 μm in diameter.
Claim 5
Dependent Claim
37 words
A method according to claim 1 wherein the neuro-active molecule is selected from the group consisting of neurotransmitters, neuropeptides, dopamine, dopamine precursors, norepinephrine, epinephrine, serotonin, substance P, somatostatin, nerve growth factor, angiotensin II, and gamma aminobutyric acid.
Claim 6
Dependent Claim
19 words
A method according to claim 4 wherein the neuro-active molecule is dopamine, dopamine precursors, norepinephrine, epinephrine and mixtures thereof.
Claim 7
Dependent Claim
16 words
A method according to claim 1 wherein the neuro-active molecule is dopamine or a dopamine precursor.
Claim 8
Dependent Claim
27 words
A method according to claim 1 wherein the amount of neuro-active molecule is from about 10 to 80 per cent of the total weight of the microsphere.
Claim 9
Dependent Claim
24 words
A method according to claim 1 wherein implantation is by injection and wherein placement is within the medial axis of the central nervous system.
Claim 10
Dependent Claim
14 words
A method according to claim 1 wherein the microsphere comprises the copolymer of poly(lactide-co-glycolide).
Claim 11
Dependent Claim
14 words
A method according to claim 1 wherein the microsphere comprises the homopolymer of polylactide.
Claim 12
Dependent Claim
14 words
A method according to claim 1 wherein the microsphere comprises the homopolymer of polyglycolide.
References Cited (Backward Citations)
USPTO Annuity & Maintenance Windows
| Annuity Stage | Window Opens | Payment Deadline | Surcharge Period Until | Estimated Fee | Status |
|---|---|---|---|---|---|
| 3.5 Years (Year 4) | 1997-10-31 | 1998-05-02 | 1998-11-01 | $2000.00 | Window Closed / Lapsed |
| 7.5 Years (Year 8) | 2001-10-31 | 2002-05-02 | 2002-11-01 | $3760.00 | Window Closed / Lapsed |
| 11.5 Years (Year 12) | 2005-10-31 | 2006-05-02 | 2006-11-01 | $7700.00 | Window Closed / Lapsed |