Patent US5351006A successfully refreshed from Google Patents.
US5351006A
Expired / Lapsed
US
⏱️ 0.0 years remaining
Method and apparatus for correcting spatial distortion in magnetic resonance images due to magnetic field inhomogeneity including inhomogeneity due to susceptibility variations
Assignee: Leland Stanford Junior University
•
Filing: 1993-10-12
•
Granted: 1994-09-27
•
Expires: 2013-10-12
Abstract
Abstract An in-vivo correction method for the non-linear, shape dependent spatial distortion in MR images due to magnetic field inhomogeneity including inhomogeneity due to susceptibility variations is disclosed. Geometric distortion at the air/tissue and tissue/bone interfaces before and after the correction is quantified using a phantom. The results are also compared to the "distortion-free" CT images of the same phantom. Magnetic susceptibility of cortical cattle bone was measured using a SQUID magnetometer and found to be -8.86 ppm which is quite similar to that of tissue (-9 ppm). The distortion at the bone/tissue boundary was negligible while that at the air/tissue boundary created displacements of about 2.0 mm with a1.5T main magnetic field and a 3.13 mT/m gradient field, a significant value if MR images are used to localize targets with the high accuracy expected for stereotaxic surgery. The correction method reduces the errors to at least the same level of accuracy as CT.
Inventors
- 👤 Thilaka S. Sumanaweera
- 👤 Gary H. Glover
- 👤 John R. Adler
Bibliographic Details
Application Number
—
Jurisdiction
US
Data Source
google_patents
Last Synchronized
2026-11-08 08:53
CPC Classifications
G; G01; G01R; G01R33/00; G01R33/20; G01R33/44; G01R33/48; G01R33/54; G01R33/56; G01R33/565; G01R33/56563; A; A61; A61B; A61B90/00; A61B90/10; G01R33/56527
Claims Analysis
Total Claims: 12
Claim 1
Independent Claim
176 words
A method of correcting spatial distortion in magnetic resonance images due to magnetic field inhomogeneity including inhomogeneity due to susceptibility variations in an object being imaged comprising the steps of a) placing the object in a magnetic field (B o ) oriented along an axis in a three axis coordinate system; b) applying first RF pulses to said object and a magnetic gradient along a first axis; c) applying first magnetic gradients along at least one axis in a plurality of first read-out of sequences, d) detecting a plurality of magnetic resonance signals in response to said plurality of first read-out sequences; e) processing said plurality of magnetic resonance signals to obtain a first complex image in an image plane; f) repeating steps b) through e) for second RF pulses, second magnetic gradients, and second read-out sequences and obtaining a second complex image in said image plane; g) obtaining a position-error profile for pixels from said complex images; and h) remapping the locations of pixels in the image plane using said position-error profile of said pixels.
Claim 2
Independent Claim
176 words
A method of correcting spatial distortion in magnetic resonance images due to magnetic field inhomogeneity including inhomogeneity due to susceptibility variations in an object being imaged comprising the steps of a) placing the object in a magnetic field (B o ) oriented along an axis in a three axis coordinate system; b) applying first RF pulses to said object and a magnetic gradient along a first axis; c) applying first magnetic gradients along at least one axis in a plurality of first read-out of sequences, d) detecting a plurality of magnetic resonance signals in response to said plurality of first read-out sequences; e) processing said plurality of magnetic resonance signals to obtain a first complex image in an image plane; f) repeating steps b) through e) for second RF pulses, second magnetic gradients, and second read-out sequences and obtaining a second complex image in said image plane; g) obtaining a position-error profile for pixels from said complex images; and h) remapping the locations of pixels in the image plane using said position-error profile of said pixels.
Claim 3
Dependent Claim
38 words
The method as defined by claim 1 wherein said read-out sequences are spin echo sequences and include 180° phase inversion pulses following 90° phase excitation pulses with the 180° pulses occurring at different times following the 90° pulses.
Claim 4
Dependent Claim
25 words
The method as defined by claim 1 wherein step c) and f) include applying at least two gradient-recalled echo sequences having echoes at different times.
Claim 5
Dependent Claim
96 words
The method as defined by claim 3 wherein step (g) includes obtaining registration error Δz(z) from γG.sub.z Δz(z)=Ω(z) where γ is the gyromagnetic ratio for protons, G z is a magnetic gradient along a Z axis and Ω(z) is frequency shift at the location, z, due to magnetic field inhomogeneity including inhomogeneity due to magnetic susceptibility variations defined as ##EQU5## where p(z,T+ΔT) is the image intensity for echo at time T+ΔT, p(z, T) is the image intensity for echo at time T, ΔT=2π/ω f , and ω f is the chemical shift between water and lipid.
Claim 6
Dependent Claim
29 words
The method as defined by claim 3 wherein step (h) includes remapping the image using new values of z from p'(x,y,z)=p(x,y,z-Δz) where p'=new image intensity and p=old image intensity.
Claim 7
Dependent Claim
241 words
Apparatus for use in correcting spatial distortion in magnetic resonance images due to magnetic field inhomogeneity including inhomogeneity due to susceptibility variations in a object being imaged comprising a) means for establishing a magnetic field (B 0 ) through said object along an axis in a three axis coordinate system; b) means for applying first RF pulses to said object and a first magnetic gradient along a first axis; c) means for applying first magnetic gradients along at least one axis in a plurality of first read-out sequences, d) means for detecting a plurality of magnetic resonance signals in response to said plurality of first read-out sequences; e) means for processing said plurality of first magnetic resonance signals to obtain a first complex image in an image plane; f) means for applying second RF pulses to said object and a second magnetic gradient along said first axis; g) means for applying second magnetic gradients along said at least one axis in a plurality of second read-out sequences; h) means for detecting a plurality of second magnetic resonance signals in response to said plurality of second read-out sequences; i) means for processing said plurality of second magnetic resonance signals to obtain a second complex image in said image plane; j) means for obtaining a position-error profile for pixels from said complex images; and k) means for shifting the location of pixels in the image plane using said position-error profile of said pixels.
Claim 8
Dependent Claim
241 words
Apparatus for use in correcting spatial distortion in magnetic resonance images due to magnetic field inhomogeneity including inhomogeneity due to susceptibility variations in a object being imaged comprising a) means for establishing a magnetic field (B 0 ) through said object along an axis in a three axis coordinate system; b) means for applying first RF pulses to said object and a first magnetic gradient along a first axis; c) means for applying first magnetic gradients along at least one axis in a plurality of first read-out sequences, d) means for detecting a plurality of magnetic resonance signals in response to said plurality of first read-out sequences; e) means for processing said plurality of first magnetic resonance signals to obtain a first complex image in an image plane; f) means for applying second RF pulses to said object and a second magnetic gradient along said first axis; g) means for applying second magnetic gradients along said at least one axis in a plurality of second read-out sequences; h) means for detecting a plurality of second magnetic resonance signals in response to said plurality of second read-out sequences; i) means for processing said plurality of second magnetic resonance signals to obtain a second complex image in said image plane; j) means for obtaining a position-error profile for pixels from said complex images; and k) means for shifting the location of pixels in the image plane using said position-error profile of said pixels.
Claim 9
Dependent Claim
36 words
Apparatus as defined by claim 6 wherein said read-out sequences are spin echo sequences and include 180° phase inversion pulses following 90° phase pulses with the 180° pulses occurring at different times following the 90° pulses.
Claim 10
Dependent Claim
19 words
Apparatus as defined by claim 6 wherein said read-out sequences are gradient-recalled echo sequences having echoes at different times.
Claim 11
Dependent Claim
101 words
Apparatus as defined by claim 7 wherein said means for obtaining a position error profile includes means for obtaining registration error Δz(z) from γG.sub.z Δz(z)=Ω(z) where γ is the gyromagnetic ratio for protons, G z is a magnetic gradient along a Z axis and Ω(z) is frequency shift at the location, z, due to magnetic field inhomogeneity including inhomogeneity due to magnetic susceptibility variations and defined as ##EQU6## where p(z,T+ΔT) is the image intensity for echo time T+ΔT, p(z,T) is the image intensity for echo time T, ΔT=2π/ω f , and ω f is the chemical shift between water and lipid.
Claim 12
Dependent Claim
36 words
Apparatus as defined by claim 8 wherein said means for shifting the location of pixels includes means for remapping the image using new values of z from p'(x,y,z)=p(x,y,z-Δz). where p'=new image intensity and p=old image intensity.
References Cited (Backward Citations)
US4823085A
Cited
US4876509A
Cited
USPTO Annuity & Maintenance Windows
| Annuity Stage | Window Opens | Payment Deadline | Surcharge Period Until | Estimated Fee | Status |
|---|---|---|---|---|---|
| 3.5 Years (Year 4) | 1997-09-26 | 1998-03-28 | 1998-09-27 | $2000.00 | Window Closed / Lapsed |
| 7.5 Years (Year 8) | 2001-09-26 | 2002-03-28 | 2002-09-27 | $3760.00 | Window Closed / Lapsed |
| 11.5 Years (Year 12) | 2005-09-26 | 2006-03-28 | 2006-09-27 | $7700.00 | Window Closed / Lapsed |