US5350839A
Expired / Lapsed
US
⏱️ 0.0 years remaining
2'-position modified compound of erythromycin or its derivative
Assignee: Taisho Pharmaceutical Co Ltd
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Filing: 1991-10-08
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Granted: 1994-09-27
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Expires: 2011-10-08
Abstract
Abstract PCT No. PCT/JP91/01368 Sec. 371 Date Apr. 15, 1992 Sec. 102(e) Date Apr. 15, 1992 PCT Filed Oct. 8, 1991 PCT Pub. No. WO92/06991 PCT Pub. Date Apr. 30, 1992.Erythromycins showing an extremely relieved bitterness at administration and an improved absorbability in vivo when orally administered are provided. A compound having a group represented by the following formula: -O-CO-O-[(CH2)m-O]n-R (wherein R represents an alkyl group having from 1 to 12 carbon atoms, m represents an integer of from 2 to 4, and n represents an integer of from 1 to 7) at the 2'-position of erythromycins or a salt thereof.
Inventors
- 👤 Toshifumi Asaka
- 👤 Yoko Misawa
- 👤 Masato Kashimura
- 👤 Shigeo Morimoto
- 👤 Yoshiaki Watanabe
- 👤 Katsuo Hatayama
Bibliographic Details
Application Number
—
Jurisdiction
US
Data Source
google_patents
Last Synchronized
2026-11-07 10:28
CPC Classifications
C; C07; C07H; C07H17/00; C07H17/04; C07H17/08
Claims Analysis
Total Claims: 3
Claim 1
Independent Claim
59 words
A compound having a group represented by the following formula (I): --O--CO--O--[(CH.sub.2).sub.m --O].sub.n --R (I) wherein R represents an alkyl group having from 1 to 12 carbon atoms, m represents an integer of from 2 to 4, and n represents an integer of from 1 to 7, at the 2'-position of an erythromycin or a pharmaceutically acceptable salt thereof.
Claim 2
Dependent Claim
59 words
A compound having a group represented by the following formula (I): --O--CO--O--[(CH.sub.2).sub.m --O].sub.n --R (I) wherein R represents an alkyl group having from 1 to 12 carbon atoms, m represents an integer of from 2 to 4, and n represents an integer of from 1 to 7, at the 2'-position of an erythromycin or a pharmaceutically acceptable salt thereof.
Claim 3
Dependent Claim
51 words
A compound as claimed in claim 1 wherein said erythromycin is erythromycin A, erythromycin B, clarithromycin, roxithromycin, azithromycin, davercin, flurithromycin, 6-0-methylerythromycin A 9-[0-(2,6-difluorobenzyl)oxime], 6-0-methylerythromycin A 9-[0-(4-bromobenzyl)oxime], 9-deoxo-ll,12-dideoxy-9,12-epoxy-11-oxo-9,10didehydroerythromycin A, 11-amino-9-deoxo-11,12-dideoxy-9,12epoxyerythromycin A, 9-deoxo-9-(4,4-dimethyl)piperidinoerythromycin A, 11-deoxy-11-[carboxy-(N-methyl, N-benzy! aminoethyl)amino]-6-0-methylerythromycin A 11,12-cyclic ester, 4"-deoxyerythromycin A or 4"-deoxyerythromycin A 11,12-cyclic carbonate, or a pharmaceutically acceptable salt thereof.
References Cited (Backward Citations)
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| Annuity Stage | Window Opens | Payment Deadline | Surcharge Period Until | Estimated Fee | Status |
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| 3.5 Years (Year 4) | 1997-09-26 | 1998-03-28 | 1998-09-27 | $2000.00 | Window Closed / Lapsed |
| 7.5 Years (Year 8) | 2001-09-26 | 2002-03-28 | 2002-09-27 | $3760.00 | Window Closed / Lapsed |
| 11.5 Years (Year 12) | 2005-09-26 | 2006-03-28 | 2006-09-27 | $7700.00 | Window Closed / Lapsed |