US4677097A
Expired / Lapsed
US
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Compositions for inducing contractile motility of the gastrointestinal tract
Assignee: KITASATO KENKYUSHO 9-1 SHIROKANE 5-CHOME MINATO-KU TOKYO-TO JAPAN A NON-PROFIT JURIDICAL PERSON OF JAPAN
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Filing: 1985-10-04
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Granted: 1987-06-30
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Expires: 2005-10-04
Abstract
Abstract A pharmaceutical composition for inducing contractile motility of the gastrointestinal tract in humans and animals, comprising as active ingredient 8,9-anhydroerythromycin 6,9-hemiketals, anhydroerythromycins, derivatives thereof and/or pharmaceutically acceptable salts thereof, in association with a pharmaceutically acceptable carrier or excipient. The active compounds may be produced by chemical modification of erythromycin and exhibit no or little antimicrobial activity. By administering the present composition to humans and animals, contractile motility of the gastrointestinal tract similar to the motility occurring naturally under normal conditions may be effectively induced.
Inventors
- 👤 Satoshi Omura
- 👤 Zen Itoh
Bibliographic Details
Application Number
—
Jurisdiction
US
Data Source
google_patents
Last Synchronized
2026-11-07 12:40
CPC Classifications
C; C07; C07H; C07H17/00; C07H17/04; C07H17/08; A; A61; A61P; A61P1/00; A61P1/14
Claims Analysis
Total Claims: 7
Claim 1
Independent Claim
73 words
A method for inducing contractile motility of the gastrointestinal tract of an animal subject which comprises administering an effective amount of an active ingredient selected from the group consisting of 8,9-anhydroerythromycin A 6,9 hemiketal; 8,9 anhydroerythromycin B 6,9-hemiketal; 8,9-anhydroerythromicin C, 6,9-hemiketal; 8,9-anhydroerythromycin D, 6,9-hemiketal; 8,9-anhydroerythromycin F 6,9-hemiketal; anhydroerythromycin A, anhydroerythromycin C, anhydroerythromycin F; erythromycin derivatives thereof and pharmaceutically acceptable salts thereof; such active ingredient being admixed with a pharmaceutically acceptable carrier or excipient.
Claim 2
Independent Claim
73 words
A method for inducing contractile motility of the gastrointestinal tract of an animal subject which comprises administering an effective amount of an active ingredient selected from the group consisting of 8,9-anhydroerythromycin A 6,9 hemiketal; 8,9 anhydroerythromycin B 6,9-hemiketal; 8,9-anhydroerythromicin C, 6,9-hemiketal; 8,9-anhydroerythromycin D, 6,9-hemiketal; 8,9-anhydroerythromycin F 6,9-hemiketal; anhydroerythromycin A, anhydroerythromycin C, anhydroerythromycin F; erythromycin derivatives thereof and pharmaceutically acceptable salts thereof; such active ingredient being admixed with a pharmaceutically acceptable carrier or excipient.
Claim 3
Dependent Claim
34 words
The method of claim 1 wherein said active ingredient is administered by intravenous injection at a daily dosage of from about 0.001 mg/kg to about 10 mg/kg of body weight based on active ingredient.
Claim 4
Dependent Claim
30 words
The method of claim 1 wherein one composition is administered orally at a daily dosage of 5 to 10 times the range to 0.001 to 10 mg/kg of body weight.
Claim 5
Dependent Claim
38 words
The method of claim 1 wherein the derivative employed is an erythromycin derivative selected from the group consisting of ethylsuccinic acid esters, ethylcarbonic acid esters, glycopeptonates, stearic acid esters, propionic acid esters, lauric acid-propionic acid diesters and lactobionate.
Claim 6
Dependent Claim
27 words
The method of claim 1 wherein the composition is administered in a form selected from the group consisting of emulsion, hydrate, solution, powder, granules, capsules and tablets.
Claim 7
Dependent Claim
20 words
The method of claim 2 wherein said active ingredient is administered by intravenous injection at a dose of 1.0 mg/kg.
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USPTO Annuity & Maintenance Windows
| Annuity Stage | Window Opens | Payment Deadline | Surcharge Period Until | Estimated Fee | Status |
|---|---|---|---|---|---|
| 3.5 Years (Year 4) | 1990-06-29 | 1990-12-29 | 1991-06-30 | $2000.00 | Window Closed / Lapsed |
| 7.5 Years (Year 8) | 1994-06-29 | 1994-12-29 | 1995-06-30 | $3760.00 | Window Closed / Lapsed |
| 11.5 Years (Year 12) | 1998-06-29 | 1998-12-29 | 1999-06-30 | $7700.00 | Window Closed / Lapsed |