Inhibitors of farnesyl protein transferase

Claim 1

A compound which inhibits farnesyl-protein transferase of the formula: ##STR9## wherein: X or Y are independently H 2 or O, provided that at least one of these is H 2 ; R 1 is H, an alkyl group, an acyl group, an alkylsulfonyl group or arylsulfonyl group, wherein alkyl and acyl groups comprise straight chain or branched chain hydrocarbons of 1 to 6 carbon atoms, or in the alternative R 1 NH may be absent; R 2 and R 3 are the side chains of naturally occurring amino acids, or in the alternative may be substituted or unsubstituted aliphatic, aromatic or heterocyclic groups, which comprise allyl, cyclohexyl, phenyl, pyridyl, imidazolyl or saturated chains of 2 to 8 carbon atoms, wherein the aliphatic substitutents may be substituted with an aromatic or heteroaromatic ring; Z is O or S; and n is 0, 1, or 2; or the pharmaceutically acceptable salts thereof.