Patent US5336620A successfully refreshed from Google Patents.
US5336620A
Expired / Lapsed
US
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Process for the production of an anticoagulant composition
Assignee: Scientific Protein Laboratories LLC
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Filing: 1993-07-22
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Granted: 1994-08-09
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Expires: 2013-07-22
Abstract
Abstract A process is disclosed for the production of an anticoagulant composition which allows for the accurate analysis of blood electrolyte concentrations. Also disclosed is the anticoagulant composition produced in accordance with the disclosed method and an apparatus containing said composition useful in the selection and sampling of blood.
Inventors
- 👤 Edward Mancilla
- 👤 Elizabeth M. Lagwinska
Bibliographic Details
Application Number
—
Jurisdiction
US
Data Source
google_patents
Last Synchronized
2026-11-03 21:26
CPC Classifications
A; A61; A61K; A61K31/00; A61K31/70; A61K31/715; A61K31/726; A61K31/727; C; C08; C08B; C08B37/00; C08B37/006; C08B37/0063; C08B37/0075; A61P; A61P7/00; A61P7/02; Y; Y10; Y10T; Y10T436/00; Y10T436/10; Y10T436/108331; Y10T436/25
Claims Analysis
Total Claims: 19
Claim 1
Independent Claim
90 words
A process for the production of an anticoagulant composition comprising a) contacting an aqueous solution of sodium heparin with an acidic ion exchange resin for a period sufficient such that aqueous effluent produced possesses a pH of about 3 or less; b) reacting said effluent with a heavy metal-containing compound suitable to produce a heavy metal heparin salt; and c) reacting said heavy metal heparin salt with an aqueous solution of lithium salts in sufficient amounts such that the resulting solution exhibits a pH of about 6 to about 7.
Claim 2
Dependent Claim
90 words
A process for the production of an anticoagulant composition comprising a) contacting an aqueous solution of sodium heparin with an acidic ion exchange resin for a period sufficient such that aqueous effluent produced possesses a pH of about 3 or less; b) reacting said effluent with a heavy metal-containing compound suitable to produce a heavy metal heparin salt; and c) reacting said heavy metal heparin salt with an aqueous solution of lithium salts in sufficient amounts such that the resulting solution exhibits a pH of about 6 to about 7.
Claim 3
Dependent Claim
14 words
The process of claim 1 further comprising filtering the solution resulting from step (c).
Claim 4
Dependent Claim
14 words
The process of claim 1 further comprising drying the solution resulting from step (c).
Claim 5
Dependent Claim
16 words
The process of claim 3 wherein the solution resulting from step (c) is dried by lyophilization.
Claim 6
Dependent Claim
22 words
The process of claim 1 wherein the solution utilized in step (a) has a concentration of about 30,000 to about 50,000 u/cc.
Claim 7
Dependent Claim
19 words
The process of claim 1 wherein the acidic ion exchange resin comprises a resin with a sulfonic acid functionality.
Claim 8
Dependent Claim
24 words
The process of claim 6 wherein the acidic ion exchange resin is selected from the group of IR-120 and IR-120 in the hydrogen form.
Claim 9
Dependent Claim
24 words
The process of claim 1 wherein the heavy metal-containing compound comprises a zinc, barium or copper salt and the lithium salt is lithium hydroxide.
Claim 10
Dependent Claim
39 words
The process of claim 8 wherein the heavy metal-containing compound is selected from the group consisting of zinc acetate dihydrate, zinc chloride, zinc sulfate, barium acetate, barium chloride, barium sulfate, copper acetate, copper chloride, copper sulfate and mixtures thereof.
Claim 11
Dependent Claim
15 words
The process of claim 1 wherein the heavy metal containing compound comprises zinc acetate dihydrate.
Claim 12
Dependent Claim
32 words
The process of claim 10 wherein zinc acetate dihydrate is utilized in amounts ranging from about 2 to about 7 grams per each 15 grams of sodium heparin used in step (a).
Claim 13
Dependent Claim
26 words
The process of claim 11 wherein about 5 grams of zinc acetate dihydrate is utilized per each 15 grams of sodium heparin used in step (a).
Claim 14
Dependent Claim
105 words
A process for the production of an anticoagulant composition comprising a) passing an aqueous solution of sodium heparin through the bed of an acidic ion exchange resin to produce an aqueous effluent having a pH of about 3 or less; b) reacting said aqueous effluent with zinc acetate dihydrate in amounts ranging from about 2 to about 7 grams per each 15 grams of sodium heparin used in step (a); c) reacting the product of step (b) with an aqueous solution of lithium hydroxide sufficient to produce a solution having a pH of about 6 to about 6.5; d) filtering the solution of step (c).
Claim 15
Dependent Claim
105 words
A process for the production of an anticoagulant composition comprising a) passing an aqueous solution of sodium heparin through the bed of an acidic ion exchange resin to produce an aqueous effluent having a pH of about 3 or less; b) reacting said aqueous effluent with zinc acetate dihydrate in amounts ranging from about 2 to about 7 grams per each 15 grams of sodium heparin used in step (a); c) reacting the product of step (b) with an aqueous solution of lithium hydroxide sufficient to produce a solution having a pH of about 6 to about 6.5; d) filtering the solution of step (c).
Claim 16
Dependent Claim
21 words
The process of claim 13 wherein the solution of step (a) has a concentration of about 30,000 to about 50,000 u/cc.
Claim 17
Dependent Claim
32 words
The process of claim 13 wherein zinc acetate dihydrate is utilized in step (b) in an amount of about 5 grams per each 15 grams of sodium heparin acid in step (a).
Claim 18
Dependent Claim
25 words
The process of claim 13 wherein the solution of step (c) is filtered with a filter media having a pore size of about 0.22 microns.
Claim 19
Dependent Claim
17 words
The process of claim 13 wherein the solution of step (c) or (d) is dried through lyophilization.
References Cited (Backward Citations)
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| Annuity Stage | Window Opens | Payment Deadline | Surcharge Period Until | Estimated Fee | Status |
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| 3.5 Years (Year 4) | 1997-08-08 | 1998-02-07 | 1998-08-09 | $2000.00 | Window Closed / Lapsed |
| 7.5 Years (Year 8) | 2001-08-08 | 2002-02-07 | 2002-08-09 | $3760.00 | Window Closed / Lapsed |
| 11.5 Years (Year 12) | 2005-08-08 | 2006-02-07 | 2006-08-09 | $7700.00 | Window Closed / Lapsed |