Patent US5330467A successfully refreshed from Google Patents.
US5330467A
Expired / Lapsed
US
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Cell treatment apparatus and method
Assignee: Individual
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Filing: 1993-04-28
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Granted: 1994-07-19
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Expires: 2013-04-28
Abstract
Abstract A catheter arrangement and associated method provides for the application of a cell treatment agent, such as genetic material or drugs to be inserted within the cells of a patient in vivo. The catheter arrangement uses an optical fiber having a prism at its tip. Laser energy from the optical fiber is directed by the prism through a window portion on a side of the catheter. The window portion has a plurality of holes so as to divide the laser energy into a plurality of microbeams. The microbeams potate cell walls of the patient's cells. A treatment agent channel in the catheter allows the treatment agent to be provided directly to the same holes through which the microbeams pass such that the treatment agent is very efficiently applied to the porations in the cell walls.
Inventors
- 👤 George S. Abela
Bibliographic Details
Application Number
—
Jurisdiction
US
Data Source
google_patents
Last Synchronized
2026-10-23 23:09
CPC Classifications
A; A61; A61B; A61B18/00; A61B18/18; A61B18/20; A61B18/22; A61B18/24; A61B17/00; A61B17/22; A61B2017/22038; A61B2017/22082; A61B2018/2255; A61B2018/2272
Claims Analysis
Total Claims: 30
Claim 1
Independent Claim
119 words
An apparatus for patient treatment comprising: a treatment catheter including an optical fiber, a body having a wall with a window means disposed therein to pass laser energy from said optical fiber, and a treatment agent channel inside said body, said window means passing laser energy for poration of a patient's cells in vivo, said treatment agent channel operable to supply treatment agent to said window means for entry into a patient's cells in vivo after the patient's cells have been porated by said laser energy, said treatment catheter further including a flushing solution channel distinct from said treatment agent channel and terminating in a flushing solution exit for applying flushing solution to a treatment site in a patient.
Claim 2
Independent Claim
119 words
An apparatus for patient treatment comprising: a treatment catheter including an optical fiber, a body having a wall with a window means disposed therein to pass laser energy from said optical fiber, and a treatment agent channel inside said body, said window means passing laser energy for poration of a patient's cells in vivo, said treatment agent channel operable to supply treatment agent to said window means for entry into a patient's cells in vivo after the patient's cells have been porated by said laser energy, said treatment catheter further including a flushing solution channel distinct from said treatment agent channel and terminating in a flushing solution exit for applying flushing solution to a treatment site in a patient.
Claim 3
Dependent Claim
59 words
The apparatus of claim 1 wherein said window means has an opening through which laser energy may pass and wherein said treatment agent channel is connected to said opening for supplying treatment agent by way of said opening for pressurized flow towards a patient's cells for entry therein after the patient's cells have been porated by said laser energy.
Claim 4
Dependent Claim
29 words
The apparatus of claim 1 wherein said window means passes laser energy in a plurality of distinct beams, each of which has a width of less than 100 microns.
Claim 5
Dependent Claim
37 words
The apparatus of claim 1 wherein said window means has a plurality of openings, each opening corresponding on a one-to-one basis with one beam of a plurality of distinct beams in which said laser energy is disposed.
Claim 6
Dependent Claim
45 words
The apparatus of claim 4 wherein said treatment agent channel is connected to said openings for supplying treatment agent by way of said openings for pressurized flow towards a patient's cells for entry therein after the patient's cells have been porated by said laser energy.
Claim 7
Dependent Claim
59 words
The apparatus of claim 5 wherein said treatment catheter includes a balloon mounted thereon and a balloon channel connected to said balloon for inflating said balloon, said window portion is on a side of said body, and wherein said window portion passes laser energy in a plurality of distinct beams, each having a width of less than 100 microns.
Claim 8
Independent Claim
115 words
An apparatus for patient treatment comprising: a treatment catheter including an optical fiber, a body having a wall with a window means disposed therein to pass laser energy from said optical fiber, and a treatment agent channel inside said body, said window means passing laser energy in a form including at least one beam passing through an opening of less than 200 microns in said window portion, said opening functioning to limit said at least one beam in diameter, said treatment agent channel disposed to supply treatment agent by way of said opening to a location for entry into a patient's cells in vivo after the patient's cells have been porated by said laser energy.
Claim 9
Independent Claim
115 words
An apparatus for patient treatment comprising: a treatment catheter including an optical fiber, a body having a wall with a window means disposed therein to pass laser energy from said optical fiber, and a treatment agent channel inside said body, said window means passing laser energy in a form including at least one beam passing through an opening of less than 200 microns in said window portion, said opening functioning to limit said at least one beam in diameter, said treatment agent channel disposed to supply treatment agent by way of said opening to a location for entry into a patient's cells in vivo after the patient's cells have been porated by said laser energy.
Claim 10
Dependent Claim
37 words
The apparatus of claim 7 wherein said treatment catheter includes a balloon mounted thereon and a balloon channel connected to said balloon for inflating said balloon and said window means is on a side of said body.
Claim 11
Dependent Claim
81 words
The apparatus of claim 8 wherein said window means has a plurality of openings, each opening corresponding to a one-to-one basis with one beam of a plurality of distinct beam in which said laser energy is disposed, and each opening connected to said treatment agent channel is connected to said openings for supplying treatment agent by way of said openings for pressurized flow towards a patient's cells for entry therein after the patient's cells have been porated by said laser energy.
Claim 12
Dependent Claim
57 words
The apparatus of claim 8 wherein said treatment catheter includes a laser catheter having said optical fiber, said body and said treatment agent channel and a flushing solution catheter connected to said laser catheter and having a flushing solution channel terminating in a flushing solution exit for applying flushing solution to a treatment site in a patient.
Claim 13
Dependent Claim
28 words
The apparatus of claim 7 wherein said at least one beam has a width of less than 100 microns and said opening is less than 100 microns across.
Claim 14
Independent Claim
119 words
An apparatus for patient treatment comprising: a laser catheter including an optical fiber, a body having a wall with a window means disposed therein to pass laser energy from said optical fiber, and a treatment agent channel inside said body, said window means passing laser energy in the form of a plurality of distinct beams, there being at least three distinct beams, each of the three beams passes out of said window portion in the same general direction for poration of a patient's cells in vivo, said treatment agent channel operable to supply treatment agent to a location for entry into a patient's cells in vivo after the patient's cells have been porated by said plurality of distinct beams.
Claim 15
Independent Claim
119 words
An apparatus for patient treatment comprising: a laser catheter including an optical fiber, a body having a wall with a window means disposed therein to pass laser energy from said optical fiber, and a treatment agent channel inside said body, said window means passing laser energy in the form of a plurality of distinct beams, there being at least three distinct beams, each of the three beams passes out of said window portion in the same general direction for poration of a patient's cells in vivo, said treatment agent channel operable to supply treatment agent to a location for entry into a patient's cells in vivo after the patient's cells have been porated by said plurality of distinct beams.
Claim 16
Dependent Claim
37 words
The apparatus of claim 12 wherein said treatment catheter includes a balloon mounted thereon and a balloon channel connected to said balloon for inflating said balloon and said window means is on a side of said body.
Claim 17
Dependent Claim
78 words
The apparatus of claim 12 wherein said window means has a plurality of openings, each opening corresponding on a one-to-one basis with one beam of a plurality of distinct beams in which said laser energy is disposed and wherein said treatment agent channel is connected to said openings for supplying treatment agent by way of said openings for pressurized flow towards a patient's cells for entry therein after the patient's cells have been porated by said laser energy.
Claim 18
Dependent Claim
39 words
The apparatus of claim 14 further comprising a flushing solution catheter connected to said laser catheter and having a flushing solution channel terminating in a flushing solution exit for applying flushing solution to a treatment site in a patient.
Claim 19
Independent Claim
107 words
A method of treating cells of a patient in vivo comprising the steps of: inserting a laser catheter into the patient; passing laser energy through an opening at a distal end of said catheter such that the laser energy is applied to the cells of the patient in vivo to cause porations in the cells; and applying a treatment agent to the cells having porations therein such that the treatment agent enters the cells through the porations said applying of the treatment agent being performed by forcing the treatment agent out said opening to follow at least one path corresponding to a beam of said laser energy.
Claim 20
Independent Claim
107 words
A method of treating cells of a patient in vivo comprising the steps of: inserting a laser catheter into the patient; passing laser energy through an opening at a distal end of said catheter such that the laser energy is applied to the cells of the patient in vivo to cause porations in the cells; and applying a treatment agent to the cells having porations therein such that the treatment agent enters the cells through the porations said applying of the treatment agent being performed by forcing the treatment agent out said opening to follow at least one path corresponding to a beam of said laser energy.
Claim 21
Dependent Claim
26 words
The method of claim 16 wherein the treatment agent includes a DNA plasmid and the applying of the treatment agent causes the cells to be transfected.
Claim 22
Dependent Claim
40 words
The method of claim 17 wherein the step of applying laser energy uses application of laser energy in the form of a plurality of distinct beams, different ones of the beams are applied to different cells at the same time.
Claim 23
Dependent Claim
27 words
The method of claim 18 and wherein said beams are applied to the cells after leaving said laser catheter with a width of less than 200 microns.
Claim 24
Dependent Claim
41 words
The method of claim 19 wherein said beams leave said laser catheter with a width of less than 100 microns and wherein there are at least 12 of said beam which exit through openings on a side of said laser catheter.
Claim 25
Dependent Claim
35 words
The method of claim 19 wherein said laser beams exit from openings on a side of said catheter and said treatment agent is forced out said openings to follow multiple paths corresponding to said beams.
Claim 26
Independent Claim
102 words
A method of treating cells of a patient in vivo comprising the steps of: applying laser energy to the cells of the patient in vivo to cause porations in the cells; and applying a treatment agent to the cells having porations therein such that the treatment agent enters the cells through the porations; and further comprising the step of inserting a laser catheter into the patient and wherein the laser energy is applied to the cells as a plurality of beams each leaving said laser catheter with a width of less than 200 microns and wherein the treatment agent is a drug.
Claim 27
Independent Claim
102 words
A method of treating cells of a patient in vivo comprising the steps of: applying laser energy to the cells of the patient in vivo to cause porations in the cells; and applying a treatment agent to the cells having porations therein such that the treatment agent enters the cells through the porations; and further comprising the step of inserting a laser catheter into the patient and wherein the laser energy is applied to the cells as a plurality of beams each leaving said laser catheter with a width of less than 200 microns and wherein the treatment agent is a drug.
Claim 28
Independent Claim
97 words
A method of treating cells of a patient in vivo comprising the steps of: inserting a laser catheter into the patient; applying laser energy to the cells of the patient in vivo to cause porations in the cells, the laser energy exiting from at least one opening in said laser catheter; and applying a treatment agent to the cells having porations therein such that the treatment agent enters the cells through the porations; and wherein said treatment agent is forced out said opening to follow at least one path corresponding to a beam of said laser energy.
Claim 29
Independent Claim
97 words
A method of treating cells of a patient in vivo comprising the steps of: inserting a laser catheter into the patient; applying laser energy to the cells of the patient in vivo to cause porations in the cells, the laser energy exiting from at least one opening in said laser catheter; and applying a treatment agent to the cells having porations therein such that the treatment agent enters the cells through the porations; and wherein said treatment agent is forced out said opening to follow at least one path corresponding to a beam of said laser energy.
Claim 30
Dependent Claim
21 words
The method of claim 23 wherein the inserting step involves insertion of the laser catheter into an artery of the patient.
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USPTO Annuity & Maintenance Windows
| Annuity Stage | Window Opens | Payment Deadline | Surcharge Period Until | Estimated Fee | Status |
|---|---|---|---|---|---|
| 3.5 Years (Year 4) | 1997-07-18 | 1998-01-17 | 1998-07-19 | $2000.00 | Window Closed / Lapsed |
| 7.5 Years (Year 8) | 2001-07-18 | 2002-01-17 | 2002-07-19 | $3760.00 | Window Closed / Lapsed |
| 11.5 Years (Year 12) | 2005-07-18 | 2006-01-17 | 2006-07-19 | $7700.00 | Window Closed / Lapsed |