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US5328681A
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Composition comprising magnetic metal oxide ultrafine particles and derivatized polysaccharides
Assignee: Meito Sangyo KK
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Filing: 1992-01-17
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Granted: 1994-07-12
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Expires: 2012-01-17
Abstract
Abstract PCT No. PCT/JP92/00031 Sec. 371 Date Sep. 17, 1992 Sec. 102(e) Date Sep. 17, 1992 PCT Filed Jan. 17, 1992 PCT Pub. No. WO92/12735 PCT Pub. Date Aug. 6, 1992.A composition containing magnetic metal oxide ultrafine particles, which comprises an aqueous sol of a complex of the magnetic metal oxide ultrafine particles with a polysaccharide, a polysaccharide derivative and/or a protein; and an organic monocarboxylic acid. The composition is free of side effects such as platelet aggregation, is safe for use with living bodies, and, in the case of intravascular administration, has no harmful effects on living bodies, and is useful in fields such as medicine and diagnostic drugs.
Inventors
- 👤 Kyoji Kito
- 👤 Hideo Nagae
- 👤 Masakatsu Hasegawa
- 👤 Yoshio Ito
- 👤 Akihiro Mizutani
- 👤 Kimio Hirose
- 👤 Yasuji Yamashita
- 👤 Nahoko Tozawa
- 👤 Keiko Yamada
- 👤 Masahiro Ohgai
- 👤 Shusaburo Hokukoku
Bibliographic Details
Application Number
—
Jurisdiction
US
Data Source
google_patents
Last Synchronized
2026-11-07 21:54
CPC Classifications
A; A61; A61K; A61K49/00; A61K49/06; A61K49/18; A61K49/1818; A61K49/1821; A61K49/1824; A61K49/1827; A61K49/1851; A61K49/1863; A61K9/00; A61K9/48; A61K9/50; A61K9/5094; G; G01; G01N; G01N2400/00; G01N2400/10; G01N2400/12; G01N2400/14; G01N2400/22; G01N2446/00; G01N2446/20; G01N2446/30; G01N2446/80; Y; Y10; Y10S; Y10S436/00; Y10S436/806; Y10T; Y10T436/00; Y10T436/24
Claims Analysis
Total Claims: 23
Claim 1
Independent Claim
56 words
A composition containing magnetic metal oxide ultrafine particles, which comprises (A) an aqueous sol of a complex of the magnetic metal oxide ultrafine particles with at least one polysaccharide derivative selected from the group consisting of carboxy polysaccharides and carboxyalkyl ethers of polysaccharides; and (B) a water-soluble monocarboxylic acid having no more than 10 carbon atoms.
Claim 2
Dependent Claim
56 words
A composition containing magnetic metal oxide ultrafine particles, which comprises (A) an aqueous sol of a complex of the magnetic metal oxide ultrafine particles with at least one polysaccharide derivative selected from the group consisting of carboxy polysaccharides and carboxyalkyl ethers of polysaccharides; and (B) a water-soluble monocarboxylic acid having no more than 10 carbon atoms.
Claim 3
Dependent Claim
44 words
The composition of claim 1 wherein the magnetic metal oxide is represented by the formula (M.sup.II O).sub.1.M.sub.2.sup.III O.sub.3 (I) wherein M II represents a divalent metal atom, M III represents a trivalent metal atom and l is a number in the range of 0≦l≦1.
Claim 4
Dependent Claim
31 words
The composition of claim 2 wherein the magnetic metal oxide is a magnetic iron oxide wherein M II in the formula (I) is divalent iron and M III is trivalent iron.
Claim 5
Dependent Claim
30 words
The composition of claim 3 wherein the divalent iron content of the magnetic iron oxide is 10 weight % or less of the whole iron in terms of iron metal.
Claim 6
Dependent Claim
28 words
The composition of claim 1 wherein the average particle size of the magnetic metal oxide ultrafine particles is in the range of about 2 to about 30 nm.
Claim 7
Dependent Claim
22 words
The composition of claim 1 wherein the complex has a particle diameter in the range of about 10 to about 500 nm.
Claim 8
Dependent Claim
30 words
The composition of claim 1 wherein the magnetization in 1 tesla of the complex is in the range of about 10 to about 150 emu per g of the metal.
Claim 9
Dependent Claim
11 words
The composition of claim 1 wherein the complex is substantially superparamagnetic.
Claim 10
Dependent Claim
25 words
The complex of claim 1 wherein the complex has a T 2 relaxivity in the range of about 5 to about 1,000 (sec.mM) -1 .
Claim 11
Dependent Claim
15 words
The composition of claim 1 wherein the organic monocarboxylic acid is one containing hydroxyl group(s).
Claim 12
Dependent Claim
15 words
The composition of claim 1 wherein the organic monocarboxylic acid is one containing amino group(s).
Claim 13
Dependent Claim
23 words
The composition of claim 1 wherein the organic monocarboxylic acid is a lower aliphatic monocarboxylic acid optionally having hydroxyl group(s) or amino group(s).
Claim 14
Dependent Claim
13 words
The composition of claim 1 wherein the organic monocarboxylic acid is lactic acid.
Claim 15
Dependent Claim
33 words
The composition of claim 1 which contains the organic monocarboxylic acid in a quantity in the range of about 1 mmol to about 30 mol per mol of the metal(s) in the complex.
Claim 16
Dependent Claim
18 words
The composition of claim 1 which has a pH in the range of about 4 to about 11.
Claim 17
Dependent Claim
27 words
The composition of claim 1 wherein the polysaccharide derivative is selected from the group consisting of alkali-modified or carboxy lower alkyl-etherified derivatives of dextran, starch and pullulan.
Claim 18
Dependent Claim
20 words
The composition of claim 1, wherein the polysaccharide derivative has an intrinsic viscosity of about 0.02 to about 0.5 dl/g.
Claim 19
Dependent Claim
33 words
The composition of claim 1, wherein the complex contains the polysaccharide derivative in a quantity of about 0.1 to about 5 weight parts per weight of the metal(s) in the magnetic metal oxide.
Claim 20
Dependent Claim
17 words
The composition of claim 1, wherein the organic monocarboxylic acid has no more than 5 carbon atoms.
Claim 21
Dependent Claim
77 words
An MRI contrast composition which comprises (A) an aqueous sol of a complex of magnetic metal oxide ultrafine particles having an average particle diameter of about 2 to about 30 nm with at least one polysaccharide derivative selected from the group consisting of carboxy polysaccharides and carboxyalkyl ethers of polysaccharides, said polysaccharide derivative having an intrinsic viscosity of about 0.02 to about 0.5 dl/g; and (B) a water-soluble monocarboxylic acid having no more than 10 carbon atoms.
Claim 22
Dependent Claim
77 words
An MRI contrast composition which comprises (A) an aqueous sol of a complex of magnetic metal oxide ultrafine particles having an average particle diameter of about 2 to about 30 nm with at least one polysaccharide derivative selected from the group consisting of carboxy polysaccharides and carboxyalkyl ethers of polysaccharides, said polysaccharide derivative having an intrinsic viscosity of about 0.02 to about 0.5 dl/g; and (B) a water-soluble monocarboxylic acid having no more than 10 carbon atoms.
Claim 23
Dependent Claim
35 words
A method for diagnosing a lesion which comprises administering the composition of claim 20 to a human being or animal and making MRI contrast photographs of the reticuloendothelial system of the human being or animal.
References Cited (Backward Citations)
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