Patent US1549754A successfully refreshed from Google Patents.
Patent US5321046A successfully refreshed from Google Patents.
US5321046A
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Hypocholesterolemic unsymmetrical dithiol ketals
Assignee: Bristol Myers Squibb Co
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Filing: 1992-10-27
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Granted: 1994-06-14
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Expires: 2012-10-27
Abstract
Abstract Disclosed herein are novel unsymmetrical dithiol ketals which are useful in the treatment or prevention of hypercholesterolemia, hyperlipoproteinemia, and atherosclerosis.
Inventors
- 👤 Sing-Yuen Sit
- 👤 John J. Wright
- 👤 Jeff A. Field
Bibliographic Details
Application Number
—
Jurisdiction
US
Data Source
google_patents
Last Synchronized
2026-11-01 18:44
CPC Classifications
C; C07; C07D; C07D213/00; C07D213/02; C07D213/04; C07D213/60; C07D213/78; C07D213/79; C07D213/80; A; A61; A61P; A61P3/00; A61P3/06; A61P9/00; A61P9/10; C07C; C07C319/00; C07C319/02; C07C319/14; C07C323/00; C07C323/10; C07C323/18; C07C323/20
Claims Analysis
Total Claims: 8
Claim 1
Independent Claim
113 words
A compound of the formula ##STR44## wherein R 1 represents C 1 to C 6 alkyl, hydroxy, hydrogen, or halogen; R 2 , R 3 , R 4 , and R 5 are identical or different and independently of one another are each hydrogen, C 1 to C 6 alkyl, phenyl, carboxylic acid esters, amides, and nitriles; R 6 , and R 7 are identical or different and independently of one another are each hydrogen, C 1 to C 6 alkyl, cyclic alkyls, chloroalkyls, fluoroalkyls, or COOR, wherein R is methyl or ethyl; m is 0-2; and n is 1-3; or a nontoxic pharmaceutically acceptable salt, hydrate, solvate or quaternary ammonium salt thereof.
Claim 2
Dependent Claim
113 words
A compound of the formula ##STR44## wherein R 1 represents C 1 to C 6 alkyl, hydroxy, hydrogen, or halogen; R 2 , R 3 , R 4 , and R 5 are identical or different and independently of one another are each hydrogen, C 1 to C 6 alkyl, phenyl, carboxylic acid esters, amides, and nitriles; R 6 , and R 7 are identical or different and independently of one another are each hydrogen, C 1 to C 6 alkyl, cyclic alkyls, chloroalkyls, fluoroalkyls, or COOR, wherein R is methyl or ethyl; m is 0-2; and n is 1-3; or a nontoxic pharmaceutically acceptable salt, hydrate, solvate or quaternary ammonium salt thereof.
Claim 3
Dependent Claim
11 words
The compound of claim 1 which is propanoic Acid, 2-[(4-hydroxy-3,5-dimethylphenyl)thio]-2-[(3,7,11-trimethyl-2,6,10-dodecatrienyl)thio]methyl ester.
Claim 4
Dependent Claim
11 words
The compound of claim 1 which is propanoic Acid, 2-[(4-hydroxy-3,5-dimethylphenyl)thio]-2-[(3,7,11-trimethyl-2,6,10-dodecatrienyl)thio]ethyl ester.
Claim 5
Dependent Claim
12 words
The compound of claim 1 which is propanoic Acid, 2-[(4-hydroxy-3,5-dimethyl phenyl)thio]-2-[(3,7,11,15-tetramethyl-2,6,10,14-hexadecatetraenyl)thio]ethyl ester.
Claim 6
Dependent Claim
12 words
The compound of claim 1 which is propanoic Acid, 2-[(4-hydroxy-3,5-dimethyl phenyl)thio]-2-[(3,7,11,15-tetramethyl-2,6,10,14-hexadecatetraenyl)thio]methyl ester.
Claim 7
Dependent Claim
12 words
The compound of claim 1 which is 5-[[1-methyl-1-[(3,7,11-trimethyl-2,6,10-dodecatrienyl) thio]ethyl]mercapto-2-hydroxybenzoic acid methyl ester.
Claim 8
Dependent Claim
18 words
A pharmaceutical composition comprising an effective amount of a compound of claim 1 and a pharmacologically acceptable carrier.
References Cited (Backward Citations)
US4461911A
Cited
US4755524A
Cited
USPTO Annuity & Maintenance Windows
| Annuity Stage | Window Opens | Payment Deadline | Surcharge Period Until | Estimated Fee | Status |
|---|---|---|---|---|---|
| 3.5 Years (Year 4) | 1997-06-13 | 1997-12-13 | 1998-06-14 | $2000.00 | Window Closed / Lapsed |
| 7.5 Years (Year 8) | 2001-06-13 | 2001-12-13 | 2002-06-14 | $3760.00 | Window Closed / Lapsed |
| 11.5 Years (Year 12) | 2005-06-13 | 2005-12-13 | 2006-06-14 | $7700.00 | Window Closed / Lapsed |