Patent US5320844A successfully refreshed from Google Patents.
US5320844A
Expired / Lapsed
US
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Composite materials for hard tissue replacement
Assignee: Ceramedical Inc
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Filing: 1992-03-12
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Granted: 1994-06-14
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Expires: 2012-03-12
Abstract
Abstract Hard tissue replacement materials and methods for making same are disclosed. In one embodiment, the present composition comprises a synthetically derived, substantially homogenous composite containing collagen component and calcium phosphate-containing component precipitated from a liquid medium in which the collagen component is contained.
Inventors
- 👤 Sung-Tsuen Liu
Bibliographic Details
Application Number
—
Jurisdiction
US
Data Source
google_patents
Last Synchronized
2026-10-24 10:36
CPC Classifications
A; A61; A61L; A61L27/00; A61L27/40; A61L27/44; A61L27/46
Claims Analysis
Total Claims: 20
Claim 1
Independent Claim
91 words
A composition useful as a hard tissue replacement material comprising a synthetically derived, substantially homogenous, solid composite consisting essentially of about 25% to about 95% by weight of collagen component and about 5% to about 75% by weight of calcium, phosphate-containing component precipitated from an aqueous liquid medium in which said collagen component and a soluble calcium-containing component and a soluble phosphate-containing component from which said calcium, phosphate-containing component is derived are contained, said aqueous liquid medium prior to said precipitation being free of insoluble calcium-component and insoluble phosphate containing component.
Claim 2
Dependent Claim
91 words
A composition useful as a hard tissue replacement material comprising a synthetically derived, substantially homogenous, solid composite consisting essentially of about 25% to about 95% by weight of collagen component and about 5% to about 75% by weight of calcium, phosphate-containing component precipitated from an aqueous liquid medium in which said collagen component and a soluble calcium-containing component and a soluble phosphate-containing component from which said calcium, phosphate-containing component is derived are contained, said aqueous liquid medium prior to said precipitation being free of insoluble calcium-component and insoluble phosphate containing component.
Claim 3
Dependent Claim
13 words
The composition of claim 1 wherein said collagen component is type 1 collagen.
Claim 4
Dependent Claim
24 words
The composition of claim 1 wherein said calcium, phosphate-containing component is selected from the group consisting of calcium phosphates, calcium apatites, and mixtures thereof.
Claim 5
Dependent Claim
22 words
The composition of claim 1 wherein the mole ratio of calcium to phosphate is in the range of about 1 to 2.
Claim 6
Independent Claim
139 words
A method for producing a collagen-calcium, phosphate-containing substantially homogeneous solid composite comprising: forming a mixture containing aqueous liquid, collagen, and either a soluble calcium-containing component or a soluble phosphate-containing component; combining said mixture with an aqueous liquid containing said soluble calcium-containing component or said soluble phosphate-containing component which is not present in said mixture, and subjecting said combination to conditions effective to cause the precipitation of a calcium, phosphate-containing component derived from said soluble calcium-containing component and said soluble phosphate-containing component, said combination prior to said precipitation being free of insoluble calcium-containing component and insoluble phosphate containing component; and recovering from said collagen and said precipitated calcium, phosphate-containing component a solid collagen-calcium, phosphate-containing material consisting essentially of about 25% to about 95% by weight of collagen and about 5% to about 75% by weight of said calcium, phosphate-containing component.
Claim 7
Independent Claim
139 words
A method for producing a collagen-calcium, phosphate-containing substantially homogeneous solid composite comprising: forming a mixture containing aqueous liquid, collagen, and either a soluble calcium-containing component or a soluble phosphate-containing component; combining said mixture with an aqueous liquid containing said soluble calcium-containing component or said soluble phosphate-containing component which is not present in said mixture, and subjecting said combination to conditions effective to cause the precipitation of a calcium, phosphate-containing component derived from said soluble calcium-containing component and said soluble phosphate-containing component, said combination prior to said precipitation being free of insoluble calcium-containing component and insoluble phosphate containing component; and recovering from said collagen and said precipitated calcium, phosphate-containing component a solid collagen-calcium, phosphate-containing material consisting essentially of about 25% to about 95% by weight of collagen and about 5% to about 75% by weight of said calcium, phosphate-containing component.
Claim 8
Dependent Claim
16 words
The method of claim 5 wherein said combination is agitated while being subjected to said conditions.
Claim 9
Dependent Claim
16 words
The method of claim 5 wherein said conditions include a pH of at least about 7.
Claim 10
Dependent Claim
16 words
The method of claim 5 wherein said conditions include a pH of at least about 10.
Claim 11
Dependent Claim
17 words
The method of claim 1 wherein said solid collagen-calcium, phosphate-containing material is a substantially homogenous solid composite.
Claim 12
Dependent Claim
36 words
The method of claim 9 wherein said recovering step comprises separating said solid collagen-calcium phosphate-containing material from one or more components other than collagen and said precipitated calcium, phosphate-containing component present with said collagen-calcium, phosphate-containing material.
Claim 13
Dependent Claim
17 words
The method of claim 10 wherein said recovering step further comprises drying said solid collagen-calcium, phosphate-containing material.
Claim 14
Independent Claim
140 words
A method for producing a collagen-calcium, phosphate homogeneous solid composite comprising: forming a mixture containing an aqueous liquid and collagen; simultaneously combining said mixture with a first aqueous liquid containing a soluble calcium-containing component and with a second aqueous liquid containing a soluble phosphate-containing component at conditions effective to cause the precipitation of a calcium, phosphate-containing component derived from said soluble calcium-containing component and said soluble phosphate-containing component, provided that said mixture, said first aqueous liquid and said second aqueous liquid prior to said precipitation are free of insoluble calcium-are free of insoluble calcium-containing component and insoluble phosphate-containing componet; and recovering from said collagen and said precipitated calcium, phosphate-containing component a solid collagen-calcium, phosphate-containing material consisting essentially of about 25% to about 95% by weight of collagen and about 5% to about 75% by weight of said calcium, phosphate-containing component.
Claim 15
Independent Claim
140 words
A method for producing a collagen-calcium, phosphate homogeneous solid composite comprising: forming a mixture containing an aqueous liquid and collagen; simultaneously combining said mixture with a first aqueous liquid containing a soluble calcium-containing component and with a second aqueous liquid containing a soluble phosphate-containing component at conditions effective to cause the precipitation of a calcium, phosphate-containing component derived from said soluble calcium-containing component and said soluble phosphate-containing component, provided that said mixture, said first aqueous liquid and said second aqueous liquid prior to said precipitation are free of insoluble calcium-are free of insoluble calcium-containing component and insoluble phosphate-containing componet; and recovering from said collagen and said precipitated calcium, phosphate-containing component a solid collagen-calcium, phosphate-containing material consisting essentially of about 25% to about 95% by weight of collagen and about 5% to about 75% by weight of said calcium, phosphate-containing component.
Claim 16
Dependent Claim
24 words
The method of claim 12 wherein said first aqueous liquid and said second aqueous liquid each have a pH of at least about 7.
Claim 17
Dependent Claim
24 words
The method of claim 12 wherein said first aqueous liquid and said second aqueous liquid each have a pH of at least about 10.
Claim 18
Dependent Claim
17 words
The method of claim 12 wherein said solid collagen-calcium, phosphate-containing material is a substantially homogenous solid composite.
Claim 19
Dependent Claim
36 words
The method of claim 15 wherein said recovering step comprises separating said solid collagen-calcium, phosphate-containing material from one or more components other than collagen and said precipitated calcium, phosphate-containing component present with said collagen-calcium, phosphate-containing material.
Claim 20
Dependent Claim
17 words
The method of claim 16 wherein said recovering step further comprises drying said solid collagen-calcium, phosphate-containing material.
References Cited (Backward Citations)
USPTO Annuity & Maintenance Windows
| Annuity Stage | Window Opens | Payment Deadline | Surcharge Period Until | Estimated Fee | Status |
|---|---|---|---|---|---|
| 3.5 Years (Year 4) | 1997-06-13 | 1997-12-13 | 1998-06-14 | $2000.00 | Window Closed / Lapsed |
| 7.5 Years (Year 8) | 2001-06-13 | 2001-12-13 | 2002-06-14 | $3760.00 | Window Closed / Lapsed |
| 11.5 Years (Year 12) | 2005-06-13 | 2005-12-13 | 2006-06-14 | $7700.00 | Window Closed / Lapsed |