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US5320837A
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Controlled release preparations of active materials
Assignee: NOF Corp
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Filing: 1991-09-23
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Granted: 1994-06-14
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Expires: 2011-09-23
Abstract
Abstract A controlled release preparation of an active material comprising a reaction product obtained by reacting (a) a copolymer consisting essentially of maleic anhydride and at least one polyalkylene glycol ether represented by formula (I): ##STR1## wherein B represents a residue of a compound having from 2 to 8 hydroxyl groups; R 1 represents an alkenyl group having from 2 to 5 carbon atoms; AO represents an oxyalkylene group having from 2 to 18 carbon atoms or a combination thereof which may be linked together in blocks or at random; R 2 represents a hydrocarbon group having from 1 to 24 carbon atoms; a represents a positive integer, b and c each represents 0 or a positive integer, and a+b+c=2 to 8; l≧0, m≧0, n≧0, and l+m+n =1 to 1000; and (b) an active material. The preparation is soluble both in water and in an organic solvent and exhibits activity for a prolonged period of time.
Inventors
- 👤 Shin-ichi Akimoto
- 👤 Susumu Honda
- 👤 Tohru Yasukohchi
Bibliographic Details
Application Number
—
Jurisdiction
US
Data Source
google_patents
Last Synchronized
2026-11-01 23:47
CPC Classifications
C; C08; C08F; C08F222/00; C08F222/04; C08F222/06; A; A61; A61K; A61K47/00; A61K47/50; A61K47/51; A61K47/56; A61K47/58; C08F8/00; C08F8/14; C08F8/30; C08F8/32; C08F8/42; C08F2800/00; C08F2800/10; C08F2800/20; C08F2810/00; C08F2810/30
Claims Analysis
Total Claims: 6
Claim 1
Independent Claim
147 words
A controlled release preparation of a biologically active compound comprising a reaction product obtained by reacting: (a) a copolymer consisting essentially of maleic anhydride and at least one polyalkylene glycol ether represented by formula (I): ##STR7## wherein Z represents the remaining residue of a compound having from 2 to 8 hydroxyl groups once all the hydroxyl groups are removed; R 1 represents an alkenyl group having from 2 to 5 carbon atoms; AO represents an oxyalkylene group having from 2 to 18 carbon atoms or a combination thereof which may be linked together in blocks or at random; R 2 represents a hydrocarbon group having from 1 to 24 carbon atoms; a represents a positive integer, b and c each represents 0 or a positive integer, and a+b+c=2 to 8; l≧9, m≧0, n≧0, and l+m+n=1 to 1000; and (b) a biologically active compound having an amino group.
Claim 2
Dependent Claim
147 words
A controlled release preparation of a biologically active compound comprising a reaction product obtained by reacting: (a) a copolymer consisting essentially of maleic anhydride and at least one polyalkylene glycol ether represented by formula (I): ##STR7## wherein Z represents the remaining residue of a compound having from 2 to 8 hydroxyl groups once all the hydroxyl groups are removed; R 1 represents an alkenyl group having from 2 to 5 carbon atoms; AO represents an oxyalkylene group having from 2 to 18 carbon atoms or a combination thereof which may be linked together in blocks or at random; R 2 represents a hydrocarbon group having from 1 to 24 carbon atoms; a represents a positive integer, b and c each represents 0 or a positive integer, and a+b+c=2 to 8; l≧9, m≧0, n≧0, and l+m+n=1 to 1000; and (b) a biologically active compound having an amino group.
Claim 3
Dependent Claim
37 words
A controlled release preparation of a biologically active compound as claimed in claim 1, wherein said biologically active compound having an amino group is an enzyme, a peptide other than an enzyme, and aminoglucoside, or a pesticide.
Claim 4
Dependent Claim
29 words
A controlled release preparation of a biologically active compound as claimed in claim 2, wherein said enzyme is a hydrolase, an oxidoreductase, an isomerase, a transferase or an eliminase.
Claim 5
Dependent Claim
52 words
A controlled release preparation of a biologically active compound as claimed in claim 2, wherein said enzyme is amylase, protease, cellulase, hemicellulase, lipase, pectinase, lysozyme, hesperidinase, anthocyanase, aminoacylase, urease, invertase, melibiase, dextranase, peptidase, ribonuclease, lactase, glucose oxidase, uricase, catalase, lipoxygenase, cytochrome C, peroxidase, glycose isomerase, cyclodextrin glucosyltransferase, transaminase, aspartase, hyaluronidase, or chondroitinase.
Claim 6
Dependent Claim
21 words
A controlled release preparation of a biologically active compound as claimed in claim 2, wherein said pesticide is 3,5-dichloroaniline or 2,6-dichloro-4-nitroaniline.
References Cited (Backward Citations)
JPS56133334A
Cited
JPS59104323A
Cited
USPTO Annuity & Maintenance Windows
| Annuity Stage | Window Opens | Payment Deadline | Surcharge Period Until | Estimated Fee | Status |
|---|---|---|---|---|---|
| 3.5 Years (Year 4) | 1997-06-13 | 1997-12-13 | 1998-06-14 | $2000.00 | Window Closed / Lapsed |
| 7.5 Years (Year 8) | 2001-06-13 | 2001-12-13 | 2002-06-14 | $3760.00 | Window Closed / Lapsed |
| 11.5 Years (Year 12) | 2005-06-13 | 2005-12-13 | 2006-06-14 | $7700.00 | Window Closed / Lapsed |