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US5320109A
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Cerebral biopotential analysis system and method
Assignee: Nellcor Puritan Bennett LLC
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Filing: 1991-10-25
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Granted: 1994-06-14
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Expires: 2011-10-25
Abstract
Abstract Disclosed is a real time diagnostic apparatus and method quantitatively evaluating, in a noninvasive manner, cerebral phenomena. Surface electroencephalographic (EEG) signals are obtained and filtered in a desired frequency range. Digital EEG data is normalized and the dynamic phase and density relations within the signal are characterized by processing the filtered signals to generate Kth-ordered spectral values where K is an integer greater than 2. A diagnostic index which quantifies the detected cerebral phenomena is then derived from the generated Kth-order spectral values.
Inventors
- 👤 Nassib G. Chamoun
- 👤 Peter A. Mead
- 👤 Hsing H. Chiang
- 👤 Vikas Saini
Bibliographic Details
Application Number
—
Jurisdiction
US
Data Source
google_patents
Last Synchronized
2026-11-05 13:46
CPC Classifications
A; A61; A61B; A61B5/00; A61B5/48; A61B5/4821; A61B5/16; A61B5/24; A61B5/316; A61B5/369; A61B5/372; A61B5/374; A61B5/72; A61B5/7235; A61B5/725; A61B5/7253; G; G16; G16H; G16H15/00; A61B5/7257
Claims Analysis
Total Claims: 51
Claim 1
Independent Claim
95 words
A method of noninvasively detecting cerebral phenomena comprising the steps of: acquiring electroencephalographic signals through at least one electrode from a body surface of a subject being analyzed; band pass filtering said electroencephalographic signals to obtain filtered signals in a desired frequency range; dividing said filtered signals into a plurality of data records; characterizing dynamic phase relations within said filtered signals by processing said filtered signals to generate Kth-order spectral values, where K is an integer greater than 2; deriving from said generated Kth-order spectral values, a diagnostic index that quantifies the detected cerebral phenomena.
Claim 2
Independent Claim
95 words
A method of noninvasively detecting cerebral phenomena comprising the steps of: acquiring electroencephalographic signals through at least one electrode from a body surface of a subject being analyzed; band pass filtering said electroencephalographic signals to obtain filtered signals in a desired frequency range; dividing said filtered signals into a plurality of data records; characterizing dynamic phase relations within said filtered signals by processing said filtered signals to generate Kth-order spectral values, where K is an integer greater than 2; deriving from said generated Kth-order spectral values, a diagnostic index that quantifies the detected cerebral phenomena.
Claim 3
Dependent Claim
61 words
The method of noninvasively detecting cerebral phenomena of claim 1 wherein the step of acquiring electroencephalographic signals further comprises the step of attaching electrodes to a head of the subject being analyzed in order to obtain a unipolar electroencephalographic signal from each region of interest of both left and right hemispheres of the subject's brain to which said electrodes are attached.
Claim 4
Dependent Claim
31 words
The method of noninvasively detecting cerebral phenomena of claim 1 wherein said Kth-order spectral values generated in said step of characterizing said dynamic phase relations are auto Kth-order spectral density values.
Claim 5
Dependent Claim
30 words
The method of noninvasively detecting cerebral phenomena of claim 1 wherein said Kth-order spectral values generated in said step of characterizing said dynamic phase relations are auto Kth-order coherence values.
Claim 6
Dependent Claim
30 words
The method of noninvasively detecting cerebral phenomena of claim 1 wherein said Kth-order spectral values generated in said step of characterizing said dynamic phase relations are auto Kth-order phase values.
Claim 7
Dependent Claim
57 words
The method of noninvasively detecting cerebral phenomena of claim 1 wherein said step of acquiring electroencephalographic signals further comprises the step of attaching electrodes to the head of the subject being analyzed in order to obtain bipolar data sets of electroencephalographic signals from left and right hemispheres of the subject's brain to which said electrodes are attached.
Claim 8
Dependent Claim
43 words
The method of noninvasively detecting cerebral phenomena of claim 6 wherein one bipolar data set is acquired from a n frontal left hemisphere of the subject's brain and another bipolar data set is acquired from a frontal right hemisphere of the subject's brain.
Claim 9
Dependent Claim
42 words
The method of noninvasively detecting cerebral phenomena of claim 6 wherein one bipolar data set is acquired from a left occipital region of the subject's brain and another bipolar data set is acquired from a right occipital region of the subject's brain.
Claim 10
Dependent Claim
42 words
The method of noninvasively detecting cerebral phenomena of claim 6 wherein one bipolar data set is acquired from a left parietal region of the subject's brain and another bipolar data set is acquired from a right parietal region of the subject's brain.
Claim 11
Dependent Claim
31 words
The method of noninvasively detecting cerebral phenomena of claim 1 wherein said Kth-order spectral values generated in said step of characterizing said dynamic phase relations are cross Kth-order spectral density values.
Claim 12
Dependent Claim
30 words
The method of noninvasively detecting cerebral phenomena of claim 1 wherein said Kth-order spectral values generated in said step of characterizing said dynamic phase relations are cross Kth-order coherence values.
Claim 13
Dependent Claim
31 words
The method of noninvasively detecting cerebral phenomena of claim 1 wherein said Kth-order spectral values are generated in said step of characterizing said dynamic phase relations are cross Kth-order phase values.
Claim 14
Dependent Claim
27 words
The method of noninvasively detecting cerebral phenomena of claim 1 wherein the cerebral phenomena being detected are pain responses during surgical stress in the subject being analyzed.
Claim 15
Dependent Claim
27 words
The method of noninvasively detecting cerebral phenomena of claim 1 wherein the physical phenomenon being detected is the degree of cerebral intoxication of the subject being analyzed.
Claim 16
Dependent Claim
27 words
The method of noninvasively detecting cerebral phenomena of claim 1 wherein the cerebral phenomena being detected are normal or abnormal cognitive processes of a subject being analyzed.
Claim 17
Dependent Claim
26 words
The method of noninvasively detecting cerebral phenomena of claim 1 wherein the cerebral phenomenon being detected is chronic ischemia or infarction in the subject being analyzed.
Claim 18
Dependent Claim
23 words
The method of noninvasively detecting cerebral phenomena of claim 1 wherein the cerebral phenomenon being detected are cognitive processes caused by neurological disorders.
Claim 19
Dependent Claim
21 words
The method of noninvasively detecting cerebral phenomena of claim 1 wherein the cerebral phenomenon being detected are altered evoked potential responses.
Claim 20
Dependent Claim
39 words
The method of noninvasively detecting cerebral phenomena of claim 18 wherein said step of acquiring electorencephalographic signals comprises acquiring electorencephalographic signals through at least one electrode placed near areas of the brain in which the evoked potential response occurs.
Claim 21
Dependent Claim
27 words
The method of noninvasively detecting cerebral phenomena of claim 18 wherein said step of acquiring electorencephalographic signals comprises acquiring electorencephalographic signals from one complete evoked potential response.
Claim 22
Dependent Claim
32 words
The method of noninvasively detecting cerebral phenomena of claim 1 wherein said Kth-order spectral values generated in said step of characterizing said dynamic phase relations are average auto Kth-order complex product values.
Claim 23
Dependent Claim
32 words
The method of noninvasively detecting cerebral phenomena of claim 1 wherein said Kth-order spectral values generated in said step of characterizing said dynamic phase relations are average cross Kth-order real product values.
Claim 24
Dependent Claim
32 words
The method of noninvasively detecting cerebral phenomena of claim 1 wherein said Kth-order spectral values generated in said step of characterizing said dynamic phase relations are average cross Kth-order complex product values.
Claim 25
Dependent Claim
32 words
The method of noninvasively detecting cerebral phenomena of claim 1 wherein said Kth-order spectral values generated in said step of characterizing said dynamic phase relations are average auto Kth-order real product values.
Claim 26
Independent Claim
93 words
A system for noninvasively detecting cerebral phenomena comprising: means for acquiring electroencephalographic signals through at least one electrode from a body surface of a subject being analyzed; means for band pass filtering said electroencephalographic signals to eliminate those signals outside a desired frequency range; means for dividing said filtered signals into a plurality of data records; means for generating Kth-order spectral values capable of characterizing dynamic phase relations within said filtered electroencephalographic signals where K is an integer greater than 2; means for deriving a diagnostic index that quantifies the detected cerebral phenomena.
Claim 27
Independent Claim
93 words
A system for noninvasively detecting cerebral phenomena comprising: means for acquiring electroencephalographic signals through at least one electrode from a body surface of a subject being analyzed; means for band pass filtering said electroencephalographic signals to eliminate those signals outside a desired frequency range; means for dividing said filtered signals into a plurality of data records; means for generating Kth-order spectral values capable of characterizing dynamic phase relations within said filtered electroencephalographic signals where K is an integer greater than 2; means for deriving a diagnostic index that quantifies the detected cerebral phenomena.
Claim 28
Dependent Claim
36 words
The system for noninvasively detecting cerebral phenomena of claim 25 further comprising a plurality of said means for acquiring electroencephalographic signals, each of said means for acquiring electroencephalographic signals being connected to said means for filtering.
Claim 29
Dependent Claim
59 words
The system for noninvasively detecting cerebral phenomena of claim 26 wherein said plurality of said means for acquiring electroencephalographic signals is a plurality of electrodes attachable to a head of a subject being analyzed to obtain a unipolar electroencephalographic signal from each of a plurality of regions of interest on both left and right hemispheres of the subject's brain.
Claim 30
Dependent Claim
94 words
The system for noninvasively detecting cerebral phenomena of claim 25 wherein said means for acquiring electroencephalographic signals comprises: a plurality of surface electrodes for mounting on a surface of a head of the subject being analyzed; means for providing defibrillator protection for limiting voltage to said amplifier during a discharge; means for amplifying said filtered signals for a high gain in order to maximize the dynamic range for high frequency, low energy wave components of said filtered signals; means for feeding said signals to an analog-to-digital converter to convert said signals to digital signals.
Claim 31
Dependent Claim
44 words
The system for noninvasively detecting cerebral phenomena of claim 25 wherein said Kth-order spectral values are auto Kth-order spectral density values and further comprising means for organizing said auto Kth-order spectral density values in at least one array of auto Kth-order spectral density values.
Claim 32
Dependent Claim
26 words
The system for noninvasively detecting cerebral phenomena of claim 25 wherein said means for acquiring electroencephalographic signals from different regions of a brain of said subject.
Claim 33
Dependent Claim
26 words
The system for noninvasively detecting cerebral phenomena of claim 25 wherein said means for generating Kth-order spectral values comprises means for computing auto Kth-order phase values.
Claim 34
Dependent Claim
26 words
The system of noninvasively detecting cerebral phenomena of claim 25 wherein said means for generating Kth-order spectral values comprises means for computing auto Kth-order coherence values.
Claim 35
Dependent Claim
28 words
The system for noninvasively detecting cerebral phenomena of claim 25 wherein said means for generating Kth-order spectral values comprises means for computing an average auto Kth-order real product.
Claim 36
Dependent Claim
28 words
The system for noninvasively detecting cerebral phenomena of claim 25 wherein said means for generating Kth-order spectral values comprises means for computing an average auto Kth-order complex product.
Claim 37
Dependent Claim
27 words
The system for noninvasively detecting cerebral phenomena of claim 25 wherein said means for generating Kth-order spectral values comprises means for computing cross Kth-order spectral density values.
Claim 38
Dependent Claim
26 words
The system for noninvasively detecting cerebral phenomena of claim 25 wherein said means for generating Kth-order spectral values comprises means for computing cross Kth-order coherence values.
Claim 39
Dependent Claim
26 words
The system for noninvasively detecting cerebral phenomena of claim 25 wherein said means for generating Kth-order spectral values comprises means for computing cross Kth-order phase values.
Claim 40
Dependent Claim
28 words
The system for noninvasively detecting cerebral phenomena of claim 25 wherein said means for generating Kth-order spectral values comprises means for computing an average cross Kth-order real product.
Claim 41
Dependent Claim
28 words
The system for noninvasively detecting cerebral phenomena of claim 25 wherein said means for generating Kth-order spectral values comprises means for computing an average cross Kth-order complex product.
Claim 42
Independent Claim
95 words
A method of generating a diagnostic index for quantifying the presence or absence of a phenomena which is represented by spectral values generated from acquired electrical signals of the phenomena, said method comprising the steps of: sorting said spectral values into predetermined bins of ranges of spectral values; summing all of the spectral values in each bin; multiplying the sum of spectral values in each bin by a predetermined coefficient to obtain a bin product; summing said bin products to obtain a diagnostic index which represents a degree of presence or absence of said phenomena.
Claim 43
Independent Claim
95 words
A method of generating a diagnostic index for quantifying the presence or absence of a phenomena which is represented by spectral values generated from acquired electrical signals of the phenomena, said method comprising the steps of: sorting said spectral values into predetermined bins of ranges of spectral values; summing all of the spectral values in each bin; multiplying the sum of spectral values in each bin by a predetermined coefficient to obtain a bin product; summing said bin products to obtain a diagnostic index which represents a degree of presence or absence of said phenomena.
Claim 44
Dependent Claim
18 words
The method of generating a diagnostic index of claim 40 wherein said acquired electrical signals are electroencephalographic signals.
Claim 45
Independent Claim
100 words
A system for generating a diagnostic index for quantifying the presence or absence of a phenomena which is represented by spectral values generated from acquired electrical signals of the phenomena, said system comprising: means for sorting said spectral values into predetermined bins of ranges of spectral values; means for summing all of the spectral values in each bin; means for multiplying the sum of spectral values in each bin by a predetermined coefficient to obtain a bin product; means for summing said bin products to obtain a diagnostic index which represents a degree of presence or absence of said phenomena.
Claim 46
Independent Claim
100 words
A system for generating a diagnostic index for quantifying the presence or absence of a phenomena which is represented by spectral values generated from acquired electrical signals of the phenomena, said system comprising: means for sorting said spectral values into predetermined bins of ranges of spectral values; means for summing all of the spectral values in each bin; means for multiplying the sum of spectral values in each bin by a predetermined coefficient to obtain a bin product; means for summing said bin products to obtain a diagnostic index which represents a degree of presence or absence of said phenomena.
Claim 47
Dependent Claim
18 words
The system for generating a diagnostic index of claim 42 wherein said acquired electrical signals are electroencephalographic signals.
Claim 48
Independent Claim
87 words
A method of noninvasively detecting cerebral phenomena comprising the steps of: acquiring electroencephalographic signals through at least one electrode from a body surface of a subject being analyzed; band pass filtering said electroencephalographic signals to obtain filtered signals in a desired frequency range; dividing said filtered signals into a plurality of data records; characterizing dynamic phase relations within said filtered signals by processing said filtered signals to generate third-order moment values; deriving from said generated third-order moment values, a diagnostic index that quantifies the detected cerebral phenomena.
Claim 49
Independent Claim
87 words
A method of noninvasively detecting cerebral phenomena comprising the steps of: acquiring electroencephalographic signals through at least one electrode from a body surface of a subject being analyzed; band pass filtering said electroencephalographic signals to obtain filtered signals in a desired frequency range; dividing said filtered signals into a plurality of data records; characterizing dynamic phase relations within said filtered signals by processing said filtered signals to generate third-order moment values; deriving from said generated third-order moment values, a diagnostic index that quantifies the detected cerebral phenomena.
Claim 50
Independent Claim
85 words
A system for noninvasively detecting cerebral phenomena comprising: means for acquiring electroencephalographic signals through at least one electrode from a body surface of a subject being analyzed; means for band pass filtering said electroencephalographic signals to eliminate those signals outside a desired frequency range; means for dividing said filtered signals into a plurality of data records; means for generating third-order moment values capable of characterizing dynamic phase relations within said filtered electroencephalographic signals; means for deriving a diagnostic index that quantifies the detected cerebral phenomena.
Claim 51
Independent Claim
85 words
A system for noninvasively detecting cerebral phenomena comprising: means for acquiring electroencephalographic signals through at least one electrode from a body surface of a subject being analyzed; means for band pass filtering said electroencephalographic signals to eliminate those signals outside a desired frequency range; means for dividing said filtered signals into a plurality of data records; means for generating third-order moment values capable of characterizing dynamic phase relations within said filtered electroencephalographic signals; means for deriving a diagnostic index that quantifies the detected cerebral phenomena.
References Cited (Backward Citations)
US4407299A
Cited
US4557270A
Cited
US4697598A
Cited
US4753246A
Cited
US4705049A
Cited
US4905285A
Cited
US4907597A
Cited
US5010891A
Cited
US4974602A
Cited
USPTO Annuity & Maintenance Windows
| Annuity Stage | Window Opens | Payment Deadline | Surcharge Period Until | Estimated Fee | Status |
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| 3.5 Years (Year 4) | 1997-06-13 | 1997-12-13 | 1998-06-14 | $2000.00 | Window Closed / Lapsed |
| 7.5 Years (Year 8) | 2001-06-13 | 2001-12-13 | 2002-06-14 | $3760.00 | Window Closed / Lapsed |
| 11.5 Years (Year 12) | 2005-06-13 | 2005-12-13 | 2006-06-14 | $7700.00 | Window Closed / Lapsed |