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US5309903A Expired / Lapsed US ⏱️ 0.0 years remaining

Method for administering surfactant to the lungs while concurrently providing one-lung ventilation

Assignee: SmithKline Beecham Corp
•
Filing: 1993-04-30
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Granted: 1994-05-10
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Expires: 2013-04-30
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Abstract

Abstract A method of administering a liquid pharmaceutical formulation, particularly a surfactant formulation, to at least one lung of a subject in need of such treatment is disclosed. The method is carried out while the subject has a breathing tube extending through the subject's mouth and larynx, and while ventilating at least one lung of the subject through the breathing tube. The method comprises simultaneously administering the liquid pharmaceutical formulation down the breathing tube and into at least one lung of the subject and ventilating at least one lung of the subject through the breathing tube. The method may be performed on premature infants to combat respiratory distress syndrome. A preferred apparatus for carrying out the method of the present invention comprises a breathing tube configured for insertion through a subject's mouth and larynx, a ventilating apparatus operatively associated with the breathing tube, and an injecting device such as a syringe operatively associated with the breathing tube for introducing a liquid pharmaceutical formulation into the breathing tube.

Inventors

  • 👤 Walker A. Long

Bibliographic Details

Application Number —
Jurisdiction US
Data Source google_patents
Last Synchronized 2026-10-23 17:09
CPC Classifications
A; A61; A61M; A61M16/00; A61M16/08; A61M16/04; A61M16/0475; A61M16/0477; A61M16/0816; A61M16/0833; A61M16/10; A61M16/14; A61M16/16

Claims Analysis

Total Claims: 10
Claim 1
Independent Claim 57 words
A method of administering a liquid surfactant formulation to at least one lung of a subject in need of such treatment while ventilating at least one lung of the subject, the method comprising simultaneously administering the liquid surfactant formulation into at least one lung of the subject, and ventilating said at least one lung of the subject.
Claim 2
Independent Claim 57 words
A method of administering a liquid surfactant formulation to at least one lung of a subject in need of such treatment while ventilating at least one lung of the subject, the method comprising simultaneously administering the liquid surfactant formulation into at least one lung of the subject, and ventilating said at least one lung of the subject.
Claim 3
Dependent Claim 33 words
A method according to claim 1, wherein said ventilating step is carried out by cyclically forcing oxygen-rich air into, and permitting oxygen-depleted air to escape from, at least one lung of the subject.
Claim 4
Dependent Claim 25 words
A method according to claim 2, wherein said ventilating step is conducted at a rate of from about 20 to about 60 breaths per minute.
Claim 5
Independent Claim 84 words
A method of administering a liquid stream of surfactant formulation to at least one lung of a subject in need of such treatment, the method comprising the steps of: ventilating at least one lung of the subject with an oxygen-rich air stream; providing introducing means for introducing a liquid surfactant formulation into said air stream; and administering the liquid surfactant formulation through the introducing means and into at least one lung of the subject while simultaneously ventilating at least one lung of the subject.
Claim 6
Independent Claim 84 words
A method of administering a liquid stream of surfactant formulation to at least one lung of a subject in need of such treatment, the method comprising the steps of: ventilating at least one lung of the subject with an oxygen-rich air stream; providing introducing means for introducing a liquid surfactant formulation into said air stream; and administering the liquid surfactant formulation through the introducing means and into at least one lung of the subject while simultaneously ventilating at least one lung of the subject.
Claim 7
Dependent Claim 56 words
A method according to claim 4, further comprising the step of providing injecting means associated with the introducing means for limiting the escape of gas from the introducing means during administration of the surfactant formulation, and wherein the step of administering the surfactant formulation is carried out by injecting the surfactant formulation into the introducing means.
Claim 8
Dependent Claim 24 words
A method according to claim 4, further comprising the step of administering a volume of liquid surfactant solution of at least 1 cubic centimeter.
Claim 9
Dependent Claim 30 words
A method according to claim 4, wherein said ventilating step comprises cyclically forcing oxygen-rich air into, and permitting oxygen-depleted air to escape from, at least one lung of the subject.
Claim 10
Dependent Claim 28 words
A method according to claim 7, further comprising the step of conducting said ventilating step at a rate of from about 20 to about 60 breaths per minute.

References Cited (Backward Citations)

US4973582A Cited
US4603124A Cited
US4826821A Cited
US5110806A Cited
US4765987A Cited
US4953547A Cited
US5207220A Cited

USPTO Annuity & Maintenance Windows

Annuity Stage Window Opens Payment Deadline Surcharge Period Until Estimated Fee Status
3.5 Years (Year 4) 1997-05-09 1997-11-08 1998-05-10 $2000.00 Window Closed / Lapsed
7.5 Years (Year 8) 2001-05-09 2001-11-08 2002-05-10 $3760.00 Window Closed / Lapsed
11.5 Years (Year 12) 2005-05-09 2005-11-08 2006-05-10 $7700.00 Window Closed / Lapsed

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