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US5300564A
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Doped sol-gel glasses for obtaining chemical interactions
Assignee: Yissum Research Development Co of Hebrew University of Jerusalem
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Filing: 1991-01-08
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Granted: 1994-04-05
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Expires: 2011-01-08
Abstract
Abstract A method is proposed of obtaining a chemical interaction between at least one reagent trapped in sol-gel glass by doping it with the reagent, and diffusible solutes or components in an adjacent liquid or gas phase. The reagents, the solutes or the components can be any organic or inorganic compounds or materials of biological origin including enzymes. The doped sol-gel glass in various forms may be useful as analytical test, chromatographic medium, sensor, catalyst or biocatalyst, electrode or enzyme electrode, or other detection device.
Inventors
- 👤 David Avnir
- 👤 Michael Ottolenghi
- 👤 Sergei Braun
- 👤 Rivka Zusman
Bibliographic Details
Application Number
—
Jurisdiction
US
Data Source
google_patents
Last Synchronized
2026-10-23 17:13
CPC Classifications
G; G01; G01N; G01N33/00; G01N33/48; G01N33/50; G01N33/68; G01N33/6863; G01N33/6869; B; B01; B01J; B01J20/00; B01J20/281; B01J20/282; B01J20/283; B01J20/291; C; C03; C03C; C03C4/00; C03C4/0007; C12; C12N; C12N11/00; C12N11/14; C12P; C12P1/00; G01N31/00; G01N31/22; G01N33/53; G01N33/543; G01N33/5436; G01N33/551; G01N33/552; G01N33/84; B01J2220/00; B01J2220/50; B01J2220/54; G01N30/00; G01N30/02; G01N30/90; G01N30/92; Y; Y02; Y02P; Y02P20/00; Y02P20/50; Y10; Y10S; Y10S530/00; Y10S530/81; Y10S530/811; Y10T; Y10T428/00; Y10T428/29; Y10T428/2982; Y10T428/2989; Y10T436/00; Y10T436/10
Claims Analysis
Total Claims: 27
Claim 1
Independent Claim
143 words
A method for obtaining an interaction between a reagent and a component, comprising (a) trapping a reagent in an inorganic sol-gel porous glass formed by polymerization of at least one metal alkoxide, semi-metal alkoxide, metal ester or semi-metal ester, the reagent being trapped in the sol-gel glass by conducting the polymerization in the presence of the reagent, the reagent being reactive after preparation of the sol-gel glass, and the sol-gel glass providing a solid support for the reagent, the polymerization including a gelling step conducted at not greater than room temperature and a drying step conducted at not greater than 45° C.; and (b) interacting the reagent trapped in the sol-gel glass with a component which is in a liquid or gas phase in pores of the sol-gel glass and which is reactive with the reagent in the pores of the sol-gel glass.
Claim 2
Independent Claim
143 words
A method for obtaining an interaction between a reagent and a component, comprising (a) trapping a reagent in an inorganic sol-gel porous glass formed by polymerization of at least one metal alkoxide, semi-metal alkoxide, metal ester or semi-metal ester, the reagent being trapped in the sol-gel glass by conducting the polymerization in the presence of the reagent, the reagent being reactive after preparation of the sol-gel glass, and the sol-gel glass providing a solid support for the reagent, the polymerization including a gelling step conducted at not greater than room temperature and a drying step conducted at not greater than 45° C.; and (b) interacting the reagent trapped in the sol-gel glass with a component which is in a liquid or gas phase in pores of the sol-gel glass and which is reactive with the reagent in the pores of the sol-gel glass.
Claim 3
Dependent Claim
29 words
A method according to claim 1, wherein the reagent is selected from the group consisting of organic compounds, stable organic radicals, organometallic compounds, and a material of biological origin.
Claim 4
Dependent Claim
29 words
A method according to claim 1, wherein the component is selected from the group consisting of organic compounds, stable organic radicals, organometallic compounds, and a material of biological origin.
Claim 5
Dependent Claim
13 words
A method according to claim 1, wherein the reagent is a pH indicator.
Claim 6
Dependent Claim
37 words
A method according to claim 1, wherein the component is a compound containing an ion selected from the group consisting of Fe 2+ , Al 3+ , Co 2+ , Ni 2+ , and Cu 2+ .
Claim 7
Dependent Claim
23 words
A method according to claim 1, wherein the sol-gel glass is in the shape of a rod, a sieve or a thin film.
Claim 8
Dependent Claim
27 words
A method according to claim 1, wherein the component is selected from the group consisting of chlorides, nitrates, sulfates, phosphate, herbicides, insecticides, inorganic ions and organic pollutants.
Claim 9
Dependent Claim
31 words
A method according to claim 1, wherein the component is at least one enzyme in a liquid phase, and the reagent is selected from the group consisting of immunoglobulins and antigens.
Claim 10
Dependent Claim
25 words
A method according to claim 1, wherein the reagent is an enzyme and the component is selected from the group consisting of immunoglobulins and antigens.
Claim 11
Dependent Claim
16 words
A method according to claim 8, wherein the enzyme is of microbial, animal or plant origin.
Claim 12
Dependent Claim
16 words
A method according to claim 9, wherein the enzyme is of microbial, animal or plant origin.
Claim 13
Dependent Claim
12 words
A method according to claim 8, wherein the enzyme is a hydrolase.
Claim 14
Dependent Claim
12 words
A method according to claim 9, wherein the enzyme is a hydrolase.
Claim 15
Dependent Claim
29 words
A method according to claim 12, wherein the hydrolase is selected from the group consisting of trypsin, alkaline phosphatase, acid phosphatase, chitinase, lipase, lactase, aminoacylase, penicillin and cephalosporin acylase.
Claim 16
Dependent Claim
29 words
A method according to claim 13, wherein the hydrolase is selected from the group consisting of trypsin, alkaline phosphatase, acid phosphatase, chitinase, lipase, lactase, aminoacylase, penicillin and cephalosporin acylase.
Claim 17
Dependent Claim
12 words
A method according to claim 8, wherein the enzyme is a lyase.
Claim 18
Dependent Claim
12 words
A method according to claim 9, wherein the enzyme is a lyase.
Claim 19
Dependent Claim
11 words
A method according to claim 15, wherein the lyase is aspartase.
Claim 20
Dependent Claim
11 words
A method according to claim 16, wherein the lyase is aspartase.
Claim 21
Dependent Claim
12 words
A method according to claim 8, wherein the enzyme is an oxidoreductase.
Claim 22
Dependent Claim
12 words
A method according to claim 9, wherein the enzyme is an oxidoreductase.
Claim 23
Dependent Claim
20 words
A method according to claim 20, wherein the enzyme is selected from the group consisting of peroxidase and glucose oxidase.
Claim 24
Dependent Claim
20 words
A method according to claim 21, wherein the enzyme is selected from the group consisting of peroxidase and glucose oxidase.
Claim 25
Dependent Claim
21 words
A method according to claim 1, wherein the reagent is an antibody and the component is an antigen of the antibody.
Claim 26
Dependent Claim
21 words
A method according to claim 1, wherein the component is an antibody and the reagent is an antigen of the antibody.
Claim 27
Dependent Claim
16 words
A method according to claim 1, wherein the component is a compound containing a metal ion.
References Cited (Backward Citations)
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