US5298643A
Expired / Lapsed
US
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Aryl imidate activated polyalkylene oxides
Assignee: Viskase Holdings Inc
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Filing: 1992-12-22
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Granted: 1994-03-29
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Expires: 2012-12-22
Abstract
Abstract Water-soluble aryl imidate activated polyalkylene oxides having improved hydrolytic stability and conjugates of the aryl imidate activated polyalkylene oxides with biologically active nucleophiles are disclosed. Methods of preparing the activated polyalkylene oxides and conjugates thereof are also disclosed.
Inventors
- 👤 Richard B. Greenwald
Bibliographic Details
Application Number
—
Jurisdiction
US
Data Source
google_patents
Last Synchronized
2026-11-01 21:27
CPC Classifications
C; C07; C07C; C07C257/00; C07C257/04; C07C257/08; C08; C08G; C08G65/00; C08G65/02; C08G65/32; C08G65/329; C08G65/331; C08G65/332; C08G65/3324; C08G65/3326; C08G65/333; C08G65/33365
Claims Analysis
Total Claims: 9
Claim 1
Independent Claim
89 words
A water-soluble aryl imidate activated polyalkylene oxide having a structure represented by (I): ##STR5## wherein R is a water-soluble polyalkylene oxide; L is NHC(O), such that the carbonyl is attached to the phenyl ring; R 1 is a moiety selected from the group consisting of alkyl, phenyl, phenylalkyl and cycloalkyl moieties; and X is a terminal moiety of said polyalkylene oxide selected from the group consisting of OH, C 1-4 alkoxy moieties and aryl imidates corresponding to the structure: ##STR6## wherein L and R 1 are defined as above.
Claim 2
Dependent Claim
89 words
A water-soluble aryl imidate activated polyalkylene oxide having a structure represented by (I): ##STR5## wherein R is a water-soluble polyalkylene oxide; L is NHC(O), such that the carbonyl is attached to the phenyl ring; R 1 is a moiety selected from the group consisting of alkyl, phenyl, phenylalkyl and cycloalkyl moieties; and X is a terminal moiety of said polyalkylene oxide selected from the group consisting of OH, C 1-4 alkoxy moieties and aryl imidates corresponding to the structure: ##STR6## wherein L and R 1 are defined as above.
Claim 3
Dependent Claim
28 words
The aryl imidate activated polyalkylene oxide of claim 1, wherein R 1 is a moiety selected from the group consisting of methyl, ethyl, phenyl, benzyl and cyclohexyl moieties.
Claim 4
Dependent Claim
15 words
The aryl imidate activated polyalkylene oxide of claim 2, wherein X is a methoxy moiety.
Claim 5
Dependent Claim
30 words
The aryl imidate activated polyalkylene oxide of claim 1, wherein said polyalkylene oxide is selected from the group consisting of polyethylene glycol, block copolymers of polyethylene glycol and polypropylene glycol.
Claim 6
Dependent Claim
16 words
The aryl imidate activated polyalkylene oxide of claim 4, wherein said polyalkylene oxide comprises polyethylene glycol.
Claim 7
Dependent Claim
25 words
The aryl imidate activated polyalkylene oxide of claim 1, wherein said polyalkylene oxide has a number average molecular weight between about 600 and 100,000 daltons.
Claim 8
Dependent Claim
26 words
The aryl imidate activated polyalkylene oxide of claim 6, wherein said polyalkylene oxide has a number average molecular weight between about 2,000 and about 20,000 daltons.
Claim 9
Dependent Claim
21 words
The aryl imidate activated polyalkylene oxide of claim 7, wherein said polyalkylene oxide has a 5,000 dalton number average molecular weight.
References Cited (Backward Citations)
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