US4791192A
Expired / Lapsed
US
⏱️ 0.0 years remaining
Chemically modified protein with polyethyleneglycol
Assignee: Takeda Pharmaceutical Co Ltd
•
Filing: 1987-06-18
•
Granted: 1988-12-13
•
Expires: 2007-06-18
Abstract
Abstract The chemically modified protein of the present invention has a strong islet-activating activity and is lower in various side effects than non-modified IAP, so that it may be employed as a prevention and therapeutic drug for diabetes.
Inventors
- 👤 Yasushi Nakagawa
- 👤 Takashi Ito
Bibliographic Details
Application Number
—
Jurisdiction
US
Data Source
google_patents
Last Synchronized
2026-10-24 03:14
CPC Classifications
C; C07; C07K; C07K1/00; C07K1/107; C07K1/1072; C07K1/1077; A; A61; A61K; A61K38/00; A61K38/16; A61K38/164; Y; Y02; Y02P; Y02P20/00; Y02P20/50; Y02P20/55
Claims Analysis
Total Claims: 17
Claim 1
Independent Claim
65 words
A chemically modified protein with insulin secreting activity which comprises an islet-activating protein produced by bacteria belonging to the genus Bordetella and polyethylene glycol moiety of the formula --O--CH.sub.2 CH.sub.2 O).sub.l R where R is a protective group for hydroxyl and l is an integer of about 7 to 700, the polyethylene glycol moiety being bound with a primary amino group of the islet-activating protein.
Claim 2
Dependent Claim
65 words
A chemically modified protein with insulin secreting activity which comprises an islet-activating protein produced by bacteria belonging to the genus Bordetella and polyethylene glycol moiety of the formula --O--CH.sub.2 CH.sub.2 O).sub.l R where R is a protective group for hydroxyl and l is an integer of about 7 to 700, the polyethylene glycol moiety being bound with a primary amino group of the islet-activating protein.
Claim 3
Dependent Claim
22 words
A chemically modified protein as claimed in claim 1, wherein the islet-activating protein is bound with the polyethylene glycol via a spacer.
Claim 4
Dependent Claim
19 words
A chemically modified protein as claimed in claim 2, wherein the spacer is a group of the formula ##STR6##
Claim 5
Dependent Claim
28 words
A chemically modified protein as claimed in claim 2, wherein the spacer is a group of the formula --CH.sub.2).sub.m wherein m is an integer from 1 to 3.
Claim 6
Dependent Claim
13 words
A chemically modified protein as claimed in claim 4, wherein m is 2.
Claim 7
Dependent Claim
28 words
A chemically modified protein as claimed in claim 2, wherein the spacer is a group of the formula ##STR7## wherein n is an integer from 1 to 3.
Claim 8
Dependent Claim
13 words
A chemically modified protein as claimed in claim 6, wherein n is 2.
Claim 9
Dependent Claim
22 words
A chemically modified protein as claimed in claim 2, wherein the average molecular weight of the polyethylene glycol is 350 to 30000.
Claim 10
Dependent Claim
22 words
A chemically modified protein as claimed in claim 2, wherein the average molecular weight of the polyethylene glycol is 1900 to 15000.
Claim 11
Dependent Claim
20 words
A chemically modified protein as claimed in claim 2, wherein the average molecular weight of the polyethylene glycol is 5000.
Claim 12
Dependent Claim
20 words
A chemically modified protein as claimed in claim 2, wherein the islet-activating protein is bound with 1 to 30 spacers.
Claim 13
Dependent Claim
20 words
A chemically modified protein as claimed in claim 2, wherein the islet-activating protein is bound with 1 to 10 spacers.
Claim 14
Dependent Claim
22 words
A chemically modified protein as claimed in claim 2, wherein the modification ratio of the primary amino group is 3 to 80%.
Claim 15
Dependent Claim
22 words
A chemically modified protein as claimed in claim 2, wherein the modification ratio of the primary amino group is 3 to 40%.
Claim 16
Dependent Claim
19 words
A chemically modified protein as claimed in claim 2, wherein R is C 1-3 alkyl or C 1-3 alkanoyl.
Claim 17
Dependent Claim
13 words
A chemically modified protein as claimed in claim 2, wherein R is methyl.
References Cited (Backward Citations)
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Cited
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US4640835A
Cited
US4609549A
Cited
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Cited
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Cited
USPTO Annuity & Maintenance Windows
| Annuity Stage | Window Opens | Payment Deadline | Surcharge Period Until | Estimated Fee | Status |
|---|---|---|---|---|---|
| 3.5 Years (Year 4) | 1991-12-13 | 1992-06-13 | 1992-12-13 | $2000.00 | Window Closed / Lapsed |
| 7.5 Years (Year 8) | 1995-12-13 | 1996-06-13 | 1996-12-13 | $3760.00 | Window Closed / Lapsed |
| 11.5 Years (Year 12) | 1999-12-13 | 2000-06-13 | 2000-12-13 | $7700.00 | Window Closed / Lapsed |