Patent US5292840A successfully refreshed from Google Patents.
US5292840A
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Polymeric supports
Assignee: 3M Co
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Filing: 1989-04-10
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Granted: 1994-03-08
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Expires: 2009-04-10
Abstract
Abstract Azlactone-functional polymer supports are useful reactive supports for the attachment of functional materials to provide novel adduct beads. The adduct beads are useful as complexing agents, catalysts, polymeric reagents, chromatographic supports, and as enzyme- or other biologically active supports. Novel carboxylate-functional polymer beads, are intermediates in the preparation of the azlactone-functional beads. Azlactone-functional supports have units of the formula: ##STR1## wherein R 1 is H or CH 3 , R 2 and R 3 independently can be an alkyl group having 1 to 14 carbon atoms, a cycloalkyl group having 3 to 14 carbon atoms, an aryl group having 5 to 12 ring atoms, an arenyl group having 6 to 26 carbon and 0 to 3 S, N, and nonperoxidic O heteroatoms, or R 2 and R 3 taken together with the carbon to which they are joined can form a carbocyclic ring containing 4 to 12 ring atoms, and n is an integer 0 or 1, the azlactone functional supports having 0.1 to 99 molar parts of crosslinking monomer incorporated therein.
Inventors
- 👤 Steven M. Heilmann
- 👤 Jerald K. Rasmussen
- 👤 Larry R. Krepski
- 👤 Dean S. Milbrath
- 👤 Patrick L. Coleman
- 👤 Margaret M. Walker
Bibliographic Details
Application Number
—
Jurisdiction
US
Data Source
google_patents
Last Synchronized
2026-11-05 13:06
CPC Classifications
A; A61; A61K; A61K39/00; A61K39/395; A61K39/39516; A61K39/39525; B; B01; B01J; B01J20/00; B01J20/22; B01J20/26; C; C07; C07K; C07K17/00; C07K17/02; C07K17/08; C08; C08F; C08F20/00; C08F20/02; C08F20/52; C08F20/54; C08F20/58; C08F8/00; C08F8/12; C08F8/14; C08F8/16; C08F8/30; C08F8/32; C08F8/48; C12; C12N; C12N11/00; C12N11/02; C12N11/08; C12N11/082; C12N11/087; C08F2800/00; C08F2800/10; C08F2800/20; C08F2810/00; C08F2810/20
Claims Analysis
Total Claims: 11
Claim 1
Independent Claim
163 words
A polymeric adduct support having units of the formula ##STR15## wherein R 1 is H or CH 3 , R 2 and R 3 each independently is an alkyl group having 1 to 14 carbon atoms, a cycloalkyl group having 3 to 14 carbon atoms, an aryl group having 5 to 12 ring atoms, an arenyl group having 6 to 26 carbon and 0 to 3 S, N, and nonperoxidic O heteroatoms, or R 2 and R 3 taken together with the carbon to which they are joined can form a carbocyclic ring containing 4 to 12 ring atoms, n=0 or 1, X is --O--, --S--, --NH--, or --NR 4 wherein R 4 is alkyl or aryl, and G is the residue of HXG which performs the adsorbing, complexing, catalyzing, separating, or reagent function of the adduct supports, said adduct support having in the range of 0 to 99 molar parts of crosslinking monomer incorporated therein, and said adduct support being a bead.
Claim 2
Dependent Claim
163 words
A polymeric adduct support having units of the formula ##STR15## wherein R 1 is H or CH 3 , R 2 and R 3 each independently is an alkyl group having 1 to 14 carbon atoms, a cycloalkyl group having 3 to 14 carbon atoms, an aryl group having 5 to 12 ring atoms, an arenyl group having 6 to 26 carbon and 0 to 3 S, N, and nonperoxidic O heteroatoms, or R 2 and R 3 taken together with the carbon to which they are joined can form a carbocyclic ring containing 4 to 12 ring atoms, n=0 or 1, X is --O--, --S--, --NH--, or --NR 4 wherein R 4 is alkyl or aryl, and G is the residue of HXG which performs the adsorbing, complexing, catalyzing, separating, or reagent function of the adduct supports, said adduct support having in the range of 0 to 99 molar parts of crosslinking monomer incorporated therein, and said adduct support being a bead.
Claim 3
Dependent Claim
21 words
The adduct support according to claim 1 wherein R 1 is hydrogen, R 2 and R 3 are methyl, and n=0.
Claim 4
Dependent Claim
24 words
The adduct support according to claim 1 wherein HXG is selected from the group consisting of adsorbants, biologically active substances, catalysts, reagents, and dyes.
Claim 5
Dependent Claim
46 words
The adduct support according to claim 1 wherein said biologically active substance is selected from the group consisting of antibodies, antigens, enzymes, cofactors, inhibitors, lectins, hormones, receptors, coagulation factors, amino acids, histones, vitamins, drugs, cell surface markers, and substances which interact with any of the foregoing.
Claim 6
Dependent Claim
12 words
The adduct support according to claim 1 which is a complexing agent.
Claim 7
Dependent Claim
12 words
The adduct support according to claim 1 which is a chromatographic support.
Claim 8
Dependent Claim
11 words
The adduct support according to claim 1 which is a catalyst.
Claim 9
Dependent Claim
12 words
The adduct support according to claim 1 which is a polymeric reagent.
Claim 10
Dependent Claim
11 words
The adduct support according to claim 1 which is an adsorbant.
Claim 11
Dependent Claim
21 words
The support according to claim 9 having in the range of 0.1 to 99 molar parts of crosslinking monomer incorporated therein.
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