Patent US5292512A successfully refreshed from Google Patents.
US5292512A
Expired / Lapsed
US
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Cosmetic or pharmaceutical composition containing microspheres of polymers or of fatty substances filled with at least one active product
Assignee: Galderma Research and Development SNC
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Filing: 1989-12-20
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Granted: 1994-03-08
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Expires: 2009-12-20
Abstract
Abstract The invention relates to a pharmaceutical or cosmetic composition for topical application, containing, in a suitable carrier, microspheres of polymers or of fatty substances filled with at least one active product, characterized in that at least 80% of the microspheres employed have a diameter of between 3 μm and 10 μm.
Inventors
- 👤 Hans Schaefer
- 👤 Francine Watts
- 👤 Christos Papantoniou
- 👤 Claude Mahieu
Bibliographic Details
Application Number
—
Jurisdiction
US
Data Source
google_patents
Last Synchronized
2026-10-25 14:44
CPC Classifications
A; A61; A61Q; A61Q5/00; A61K; A61K9/00; A61K9/48; A61K9/50; A61K8/00; A61K8/02; A61K8/0241; A61K8/18; A61K8/30; A61K8/33; A61K8/37; A61K8/375; A61K8/49; A61K8/494; A61K8/4953; A61K8/67; A61K8/671; A61K8/673; A61K8/675; A61K8/72; A61K8/84; A61K8/85; A61K9/14; A61K9/16; A61K9/1605; A61K9/1617; A61K9/1629; A61K9/1641; A61K9/1647; A61P; A61P17/00; A61P25/00; A61P25/24; A61P25/26; A61Q19/00; A61Q19/08; A61K2800/00; A61K2800/40; A61K2800/41; A61K2800/412; A61K2800/42; A61K2800/43; A61K2800/434; A61K2800/56; A61Q7/00
Claims Analysis
Total Claims: 34
Claim 1
Independent Claim
134 words
A pharmaceutical or cosmetic composition for topical application to the skin comprises, in a pharmaceutically or cosmetically acceptable carrier for topical application to the skin, microspheres of a polymer or fatty substance having a melting point approximately higher than 50° C., said microspheres being filled with at least one pharmaceutically or cosmetically active product and having a size such that they enter the sebaceous follicle on topical application to the skin and selectively and progressively reach the follicular canal whereby the said pharmaceutically or cosmetically active product diffuses into the follicular canal and surrounding tissue and the solid substrate forming said microspheres is rejected thereby avoiding any undesirable reaction between the organism and said solid substrate, at least 80 weight percent of said microspheres having a diameter ranging from 3 μm to 10 μm.
Claim 2
Dependent Claim
134 words
A pharmaceutical or cosmetic composition for topical application to the skin comprises, in a pharmaceutically or cosmetically acceptable carrier for topical application to the skin, microspheres of a polymer or fatty substance having a melting point approximately higher than 50° C., said microspheres being filled with at least one pharmaceutically or cosmetically active product and having a size such that they enter the sebaceous follicle on topical application to the skin and selectively and progressively reach the follicular canal whereby the said pharmaceutically or cosmetically active product diffuses into the follicular canal and surrounding tissue and the solid substrate forming said microspheres is rejected thereby avoiding any undesirable reaction between the organism and said solid substrate, at least 80 weight percent of said microspheres having a diameter ranging from 3 μm to 10 μm.
Claim 3
Dependent Claim
49 words
The composition of claim 1 wherein said polymer is selected from the group consisting of styrene-based polymer, a β-alanine-based polymer, a polymer derived from acrylic or methacrylic acid, a polyester derived from lactic or glycolic acid or a mixture thereof, a crosslinked protein and a protein coagulated by heat.
Claim 4
Dependent Claim
13 words
The composition of claim 1 wherein said polymer is a β-alanine based polymer.
Claim 5
Dependent Claim
22 words
The composition of claim 1 wherein said polymer is a polyester derived from lactic acid or glycolic acid or a mixture thereof.
Claim 6
Dependent Claim
29 words
The composition of claim 1 wherein said fatty substance is selected from the group consisting of a fatty alcohol and a derivative of an alcohol and a fatty acid.
Claim 7
Dependent Claim
22 words
The composition of claim 5 wherein said fatty substance has a melting point between approximately higher than 50° C. and 100° C.
Claim 8
Dependent Claim
83 words
The composition of claim 1 wherein said active product is selected from the group consisting of an agent for treating acne, a skin-reinforcing agent, a hair treating agent, an antifungal, an astringent, an antibiotic, an antiviral agent, an antihypertensive agent, an antioginal vasodilator, an agent for treating a cardiovascular disorder, an antiinflammatory agent, an antiallergen, an antiprurior, a growth factor of peptidic or proteinic nature, a neurostimulant, an antidepressant agent, a natural compound employed in neurobiological research, an anaesthetic and a hormone steroid.
Claim 9
Dependent Claim
29 words
The composition of claim 1 wherein said active product is minoxidil as an anti hair loss or regrowth agent in combination with S-carboxymethylcysteine or octopirox as an antiseborrheic agent.
Claim 10
Dependent Claim
19 words
The composition of claim 1 wherein said pharmaceutically or cosmetically acceptable carrier is an aqueous carrier or an oil.
Claim 11
Dependent Claim
14 words
The composition of claim 9 wherein said aqueous carrier is a lipophilic aqueous carrier.
Claim 12
Dependent Claim
16 words
The composition of claim 1 wherein said pharmaceutically or cosmetically acceptable carrier is a hydroalcoholic solution.
Claim 13
Dependent Claim
19 words
The composition of claim 1 wherein said pharmaceutically or cosmetically acceptable carrier is an aqueous solution of a silicone.
Claim 14
Dependent Claim
20 words
The composition of claim 1 wherein said pharmaceutically or cosmetically acceptable carrier is an aqueous carrier containing a gelling agent.
Claim 15
Dependent Claim
29 words
The composition of claim 1 wherein said microspheres are present in an amount ranging from 1 to 40 percent by weight based on the total weight of said composition.
Claim 16
Dependent Claim
33 words
The composition of claim 1 wherein said pharmaceutically or cosmetically active product is present in an amount ranging from 0.05 to 60 percent by weight based on the total weight of said composition.
Claim 17
Dependent Claim
27 words
Composition according to claim 7, characterized in that it contains vitamin A, retinoic acid or one of its derivatives, or benzoyl peroxide, as agent for treating acne.
Claim 18
Dependent Claim
15 words
Composition according to claim 7, characterized in that it contains nystatin or econazole as antifungal.
Claim 19
Dependent Claim
14 words
Composition according to claim 7, characterized in that it contains aluminium chloride as astringent.
Claim 20
Dependent Claim
15 words
Composition according to claim 7, characterized in that it contains erythromycin or tetracycline as antibiotic.
Claim 21
Dependent Claim
14 words
Composition according to claim 7, characterized in that it contains vidarabine as antiviral agent.
Claim 22
Dependent Claim
14 words
Composition according to claim 7, characterized in that it contains clonidine hydrochloride as antihypertensive.
Claim 23
Dependent Claim
13 words
Composition according to claim 7, characterized in that it contains bradikynine as vasodilator.
Claim 24
Dependent Claim
26 words
Composition according to claim 7, characterized in that it contains a peptide of the tachykinins group, in particular "substance P", as agent for treating cardiovascular disorders.
Claim 25
Dependent Claim
19 words
Composition according to claim 7, characterized in that it contains aspirin or hydrocortisone or its derivatives as antiinflammatory agent.
Claim 26
Dependent Claim
14 words
Composition according to claim 7, characterized in that it contains a chromoglycate as antiallergen.
Claim 27
Dependent Claim
15 words
Composition according to claim 7, characterized in that it contains a phenothiazine derivative as antipruritic.
Claim 28
Dependent Claim
21 words
Composition according to claim 7, characterized in that it contains the epidermic growth factor (EGF) as growth factor of peptidic nature.
Claim 29
Dependent Claim
15 words
Composition according to claim 7, characterized in that it contains caffeine or theophylline as neurostimulant.
Claim 30
Dependent Claim
15 words
Composition according to claim 7, characterized in that it contains a lithium salt as antidepressant.
Claim 31
Dependent Claim
18 words
Composition according to claim 7, characterized in that it contains capsaicine as natural compound employed in neurobiological research.
Claim 32
Dependent Claim
15 words
Composition according to claim 7, characterized in that it contains lidocaine or procaine as anaesthetic.
Claim 33
Dependent Claim
14 words
Composition according to claim 7, characterized in that it contains nitroglycerine as antianginal agent.
Claim 34
Dependent Claim
40 words
Composition according to claim 1, characterized in that the carrier is an oil consisting of a triglyceride of C 8 -C 10 fatty acids or a mixture of several of these triglycerides, of vaseline, of liquid paraffin or of lanolin.
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USPTO Annuity & Maintenance Windows
| Annuity Stage | Window Opens | Payment Deadline | Surcharge Period Until | Estimated Fee | Status |
|---|---|---|---|---|---|
| 3.5 Years (Year 4) | 1997-03-07 | 1997-09-06 | 1998-03-08 | $2000.00 | Window Closed / Lapsed |
| 7.5 Years (Year 8) | 2001-03-07 | 2001-09-06 | 2002-03-08 | $3760.00 | Window Closed / Lapsed |
| 11.5 Years (Year 12) | 2005-03-07 | 2005-09-06 | 2006-03-08 | $7700.00 | Window Closed / Lapsed |