Patent US5288717A successfully refreshed from Google Patents.
US5288717A
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Alkali metal 8,9-dehydroestrone sulfate esters
Assignee: Wyeth LLC
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Filing: 1992-12-03
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Granted: 1994-02-22
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Expires: 2012-12-03
Abstract
Abstract This invention presents alkali metal salts of 8,9-dehydroestrone, its sulfate ester, and stable compositions thereof, as well as processes for their production. The sulfate ester salts are useful in estrogen replacement therapy.
Inventors
- 👤 Panolil C. Raveendranath
- 👤 John A. Wichtowski
Bibliographic Details
Application Number
—
Jurisdiction
US
Data Source
google_patents
Last Synchronized
2026-11-02 15:38
CPC Classifications
C; C07; C07J; C07J31/00; C07J1/00; C07J1/0051; C07J1/0059; A; A61; A61P; A61P15/00; A61P15/12; A61P19/00; A61P19/08; A61P19/10; A61P3/00; A61P3/06; A61P5/00; A61P5/24; A61P5/36; A61P9/00; A61P9/10; C07J31/006
Claims Analysis
Total Claims: 9
Claim 1
Independent Claim
6 words
An alkali metal salt of 8,9-dehydroestrone.
Claim 2
Dependent Claim
6 words
An alkali metal salt of 8,9-dehydroestrone.
Claim 3
Dependent Claim
12 words
A salt of claim 1 which is the sodium salt of 8,9-dehydroestrone.
Claim 4
Dependent Claim
12 words
A salt of claim 1 which is the potassium salt of 8,9-dehydroestrone
Claim 5
Dependent Claim
12 words
A salt of claim 1 which is the lithium salt of 8,9-dehydroestrone.
Claim 6
Dependent Claim
41 words
A process for the production of a stable composition containing an alkali metal salt of 8,9-dehydroestrone-3-sulfate which comprises reacting trimethylamine-sulfurtrioxide with an alkali metal salt of 8,9-dehydroestrone in a polar, aprotic solvent in the presence of a stabilizing amount of tris(hydroxymethyl)aminomethane.
Claim 7
Dependent Claim
41 words
A process for the production of a stable composition containing an alkali metal salt of 8,9-dehydroestrone-3-sulfate which comprises reacting trimethylamine-sulfurtrioxide with an alkali metal salt of 8,9-dehydroestrone in a polar, aprotic solvent in the presence of a stabilizing amount of tris(hydroxymethyl)aminomethane.
Claim 8
Dependent Claim
55 words
A process for the production of a stable composition containing an alkali metal salt of 8,9-dehydroestrone-3-sulfate which comprises reacting trimethylamine-sulfurtrioxide with an alkali metal salt of 8,9-dehydroestrone in a polar, aprotic solvent, adding a stabilizing amount of tris(hydroxymethyl)aminomethane to the reaction mixture, and recovering said stable mixture of alkali metal salt of 8,9-dehydroestrone and tris(hydroxymethyl)aminomethane.
Claim 9
Dependent Claim
55 words
A process for the production of a stable composition containing an alkali metal salt of 8,9-dehydroestrone-3-sulfate which comprises reacting trimethylamine-sulfurtrioxide with an alkali metal salt of 8,9-dehydroestrone in a polar, aprotic solvent, adding a stabilizing amount of tris(hydroxymethyl)aminomethane to the reaction mixture, and recovering said stable mixture of alkali metal salt of 8,9-dehydroestrone and tris(hydroxymethyl)aminomethane.
References Cited (Backward Citations)
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