US5285159A
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RF pulse cascade for the generation of NMR spectra
Assignee: Spectrospin AG
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Filing: 1990-10-06
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Granted: 1994-02-08
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Expires: 2010-10-06
Abstract
Abstract PCT No. PCT/EP90/01681 Sec. 371 Date Jun. 1, 1992 Sec. 102(e) Date Jun. 1, 1992 PCT Filed Oct. 6, 1990 PCT Pub. No. WO91/09322 PCT Pub. Date Jun. 27, 1991.A method for generating a spectrum of NMR signals with rectangular characteristic in the frequency space by radiating a sequence of RF pulses onto a sample in the homogeneous magnetic field is presented. The RF pulses of the sequence are amplitude modulated and the enveloping function of the sequence consists of a superposition of bell-curve-shaped RF pulses with optimized positions of the maxima, pulse widths and peak amplitudes. The response signals, in dependence on the standardized frequency, shift, approximate virtually ideally, a rectangular function. The method is applicable with success especially in image generation for NMR tomography, in multidimensional NMR spectroscopy, as well as in volume selective NMR spectroscopy.
Inventors
- 👤 Geoffrey Bodenhausen
- 👤 Lyndon Emsley
Bibliographic Details
Application Number
—
Jurisdiction
US
Data Source
google_patents
Last Synchronized
2026-11-07 10:34
CPC Classifications
G; G01; G01R; G01R33/00; G01R33/20; G01R33/44; G01R33/446; G01R33/48; G01R33/54; G01R33/56; G01R33/46; G01R33/4616
Claims Analysis
Total Claims: 20
Claim 1
Independent Claim
118 words
A method for generating a spectrum of nuclear magnetic resonance signals comprising the steps of: a) selecting a pulse sequence with a number n of at least 2 but not more than 10 amplitude modulated bell shaped RF pulses, each RF pulse comprising an amplitude w k max , an extremum position t k max , and a width a k ; b) varying the amplitude, extremum position, and width of each pulse to minimize a deviation of a signal response frequency space envelop from a rectangular function: c) radiating the pulse sequence onto a sample located in a homogeneous static magnetic field to produce a nuclear magnetic resonance signal response with an approximately rectangular frequency space envelope.
Claim 2
Independent Claim
118 words
A method for generating a spectrum of nuclear magnetic resonance signals comprising the steps of: a) selecting a pulse sequence with a number n of at least 2 but not more than 10 amplitude modulated bell shaped RF pulses, each RF pulse comprising an amplitude w k max , an extremum position t k max , and a width a k ; b) varying the amplitude, extremum position, and width of each pulse to minimize a deviation of a signal response frequency space envelop from a rectangular function: c) radiating the pulse sequence onto a sample located in a homogeneous static magnetic field to produce a nuclear magnetic resonance signal response with an approximately rectangular frequency space envelope.
Claim 3
Dependent Claim
30 words
The method according to claim 1, wherein the minimization of the deviation of the envelope is accomplished by use of a numerical fit program on an automatic data processing installation.
Claim 4
Dependent Claim
35 words
The method according to claim 1, wherein the minimization of the deviation of the envelope is accomplished by optimization of a predetermined error function, which describes the deviation of the envelope from a rectangular function.
Claim 5
Dependent Claim
24 words
The method according to claim 3, wherein the minimization is stopped when the absolute value of the error function exceeds a predetermined limit value.
Claim 6
Dependent Claim
22 words
The method according to claim 1, wherein the sequence contains RF pulses whose amplitude distribution follows the form of a Lorentz curve.
Claim 7
Dependent Claim
22 words
The method according to claim 1, wherein the sequence contains RF pulses whose amplitude distribution follows the form of a Gaussian curve.
Claim 8
Dependent Claim
21 words
The method according to claim 1, wherein n=3 and the method is used for the selective inversion of nuclear magnetic moments.
Claim 9
Dependent Claim
72 words
The method according to claim 7, wherein the pulse sequence has a time duration t p , a kth pulse has a half pulse width δt k 1/2 at a half pulse amplitude w.sub.k.sup.max /2, a.sub.k =ln2/(δt.sub.k.sup.1/2).sup.2, and w.sub.k.sup.max, t.sub.k.sup.max /t.sub.p and δt.sub.k.sup.1/2 /t.sub.p have values in ranges: 1.2<w.sub.2.sup.max /w.sub.1.sup.max <1.5; 0.3<w.sub.3.sup.max /w.sub.1.sup.max <0.7 15<δt.sub.1.sup.1/2 /t.sub.p <25; 15<δt.sub.2.sup.1/2 /t.sub.p <25; 20<δt.sub.3.sup.1/2 /t.sub.p <30; 20<t.sub.1.sup.max /t.sub.p <40; 40<t.sub.2.sup.max /t.sub.p <60; 70<t.sub.3.sup.max /t.sub.p <90.
Claim 10
Dependent Claim
47 words
The method according to claim 8, wherein w k max , t k max , and δt k 1/2 /t p have values: w.sub.1.sup.max =-1.00; w.sub.2.sup.max =1.37; w.sub.3.sup.max =0.49; δt.sub.1.sup.1/2 /t.sub.p =18.9; δt.sub.2.sup.1/2 /t.sub.p =18.3; δt.sub.3.sup.1/2 /t.sub.p =24.3; t.sub.1.sup.max /t.sub.p =28.7; t.sub.2.sup.max /t.sub.p =50.8; t.sub.3.sup.max /t.sub.p =79.5.
Claim 11
Dependent Claim
20 words
The method according to claim 1, wherein n=4, and the method is used for an inphase excitation of transverse magnetization.
Claim 12
Dependent Claim
98 words
The method according to claim 10, wherein the pulse sequence has a time duration t p , the kth pulse has a half pulse width δt k 1/2 at a half pulse amplitude w k max /2, a k =ln2/(δt k 1/2 ) 2 , and w k max , t k max /t p and δt k 1/2 /t p have values in ranges: 0.95<w.sub.2.sup.max /w.sub.1.sup.max <1.35; -1.7<w.sub.3.sup.max /w.sub.1.sup.max <-1.3; -0.7<w.sub.4.sup.max /w.sub.1.sup.max <-1.4; 15<δt.sub.1.sup.1/2 /t.sub.p <20; 10<δt.sub.2.sup.1/2 /t.sub.p <15; 10<δt.sub.3.sup.1/2 /t.sub.p 15; 10<δt.sub.4.sup.1/2 /t.sub.p <20; 5<t.sub.1.sup.max /t.sub.p <25; 40<t.sub.2.sup.max /t.sub.p <60; 55<t.sub.3.sup.max /t.sub.p <75; 75<t.sub.4.sup.max /t.sub.p <95.
Claim 13
Dependent Claim
54 words
The method according to claim 11, wherein w k max , t k max and δt k 1/2 /t p have values: w.sub.1.sup.max =0.62; w.sub.2.sup.max =0.72; w.sub.3.sup.max =-0.91; w.sub.4.sup.max =-0.33 δt.sub.1.sup.1/2 /t.sub.p =17.2; δt.sub.2.sup.1/2 /t.sub.p =12.9; δt.sub.3.sup.1/2 /t.sub.p =11.9; δt.sub.4.sup.1/2 /t.sub.p =13.9; t.sub.1.sup.max /t.sub.p =17.7; t.sub.2.sup.max /t.sub.p =49.2; t.sub.3.sup.max /t.sub.p =65.3; t.sub.4.sup.max /t.sub.p =89.2.
Claim 14
Dependent Claim
19 words
The method according to claim 1 further comprising the step of: d) generating section images for an NMR tomograph.
Claim 15
Dependent Claim
17 words
The method according to claim 1 further comprising the step of: d) generating a multidimensional NMR spectroscopy.
Claim 16
Dependent Claim
13 words
The method according to claim 14, wherein the NMR spectroscopy is volume selective.
Claim 17
Dependent Claim
20 words
The method according to claim 14, wherein the sequence of n RF pulses is part of a NOESY pulse sequence.
Claim 18
Dependent Claim
20 words
The method according to claim 14, wherein the sequence of n RF pulses is part of a COSY pulse sequence.
Claim 19
Dependent Claim
157 words
A nuclear magnetic resonance spectrometer with an RF pulse generator and an arrangement for the drive of the RF pulse generator, the arrangement comprising a memory for the storage of data sets for the generation of RF pulse sequences wherein the memory comprises a data set for the generation of a pulse sequence with a number n of at least two but not more than 10 amplitude modulated bell shaped RF pulses, each RF pulse comprising an amplitude w k max , an extremum position t k max , and a width a k and, in advance, the amplitude distribution of the entire pulse sequence has been determined in a suitable optimization procedure under a criterion of a minimization of a deviation of an envelope of a nuclear magnetic resonance signal response in frequency space from a rectangular function by variation, for each pulse, of w k max , t k max , and a k .
Claim 20
Dependent Claim
157 words
A nuclear magnetic resonance spectrometer with an RF pulse generator and an arrangement for the drive of the RF pulse generator, the arrangement comprising a memory for the storage of data sets for the generation of RF pulse sequences wherein the memory comprises a data set for the generation of a pulse sequence with a number n of at least two but not more than 10 amplitude modulated bell shaped RF pulses, each RF pulse comprising an amplitude w k max , an extremum position t k max , and a width a k and, in advance, the amplitude distribution of the entire pulse sequence has been determined in a suitable optimization procedure under a criterion of a minimization of a deviation of an envelope of a nuclear magnetic resonance signal response in frequency space from a rectangular function by variation, for each pulse, of w k max , t k max , and a k .
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| 3.5 Years (Year 4) | 1997-02-07 | 1997-08-09 | 1998-02-08 | $2000.00 | Window Closed / Lapsed |
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