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US4818940A Expired / Lapsed US ⏱️ 0.0 years remaining

Method for measuring nuclear magnetic resonance

Assignee: Bruker Biospin MRI GmbH
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Filing: 1987-09-18
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Granted: 1989-04-04
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Expires: 2007-09-18
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Abstract

Abstract For recording a nuclear magnetic resonance tomogram according to a Fourier-transform method, a Carr-Purcell-Gill-Meiboom pulse sequence is used for the excitation of a body to produce a sequence of spin-echo signals. A time-limited phase-encoding magnetic gradient field G X is imposed between each pair of 180° pulses of the sequence. The phase-encoding magnetic gradient field is modified after every 180° pulse so that every spin-echo signal corresponds to a different projection of the body. The magnetic gradient fields used in the recording are regulated in intensity and duration in such a way that a spin-phase condition at each 180° pulse of the pulse sequence remains effectively constant. Thereby, it is possible to construct a complete tomographic recording with a single pulse-sequence excitation, so that the time required for such recordings can be reduced to a fraction of the time needed for recording nuclear-magnetic-resonance tomograms conventionally.

Inventors

  • 👤 Jurgen Hennig
  • 👤 Arno Nauerth

Bibliographic Details

Application Number —
Jurisdiction US
Data Source google_patents
Last Synchronized 2026-10-25 17:50
CPC Classifications
G; G01; G01R; G01R33/00; G01R33/20; G01R33/44; G01R33/48; G01R33/54; G01R33/56; G01R33/561; G01R33/5615; G01R33/5617

Claims Analysis

Total Claims: 6
Claim 1
Independent Claim 380 words
A nuclear-magnetic-resonance Fourier-transform tomographic method for imaging cross sections of a body, the method comprising exposing the body to a homogeneous magnetic field, superimposing upon the body a time-limited selection magnetic gradient field, during the selection magnetic gradient field irradiating the body with an essentially 90° pulse, subsequently irradiating the body with a timed sequence of essentially 180° pulses to produce a sequence of spin-echo nuclear induction signals, the relative phases and spacing of the 90° pulse and the 180° pulses being selected to define a Carr-Purcell-Gill-Meiboom pulse sequence so that a spin-echo nuclear induction signal occurs in an interval between each pair of adjacent essentially 180° pulses in the pulse sequence, during the sequence of essentially 180° pulses superimposing upon the body a sequence of time-limited phase-encoding magnetic gradient fields and time-limited recording magnetic gradient fields, each phase-encoding magnetic gradient field being imposed during a time interval between a pair of adjacent essentially 180° pulses of the Carr-Purcell-Gill-Meiboom pulse sequence, a portion of the phase-encoding magnetic gradient field being imposed between the first essentially 180° pulse of the pair of pulses and a midpoint of the spin-echo nuclear induction signal occurring between the pair of pulses, each recording magnetic gradient field being imposed during the time interval between a pair of adjacent essentially 180° pulses of the Carr-Purcell-Gill-Meiboom pulse sequence coincident with the occurrence of the spin-echo nuclear induction signal between the pair of pulses, the phase-encoding magnetic gradient fields being changed after each essentially 180° pulse in accordance with a Fourier-transform tomographic imaging method, the form and timing of each time-limited magnetic gradient field relative to the substantially 180° pulses and the spin-echo nuclear induction signals being selected so that spin dephasing which arises during the magnetic gradient field is substantially cancelled at the end of the time-limited gradient field so that a spin phase condition at the time of each essentially 180° pulse subsequent to the first such pulse is substantially the same as a spin phase condition at the time of the preceding essentially 180° pulse, sampling and digitizing the spin-echo nuclear induction signals to form digitized nuclear signal data, and combining such digitized nuclear signal data in accordance with the Fourier-transform tomographic method to form a tomographic image of the cross section of the body.
Claim 2
Dependent Claim 380 words
A nuclear-magnetic-resonance Fourier-transform tomographic method for imaging cross sections of a body, the method comprising exposing the body to a homogeneous magnetic field, superimposing upon the body a time-limited selection magnetic gradient field, during the selection magnetic gradient field irradiating the body with an essentially 90° pulse, subsequently irradiating the body with a timed sequence of essentially 180° pulses to produce a sequence of spin-echo nuclear induction signals, the relative phases and spacing of the 90° pulse and the 180° pulses being selected to define a Carr-Purcell-Gill-Meiboom pulse sequence so that a spin-echo nuclear induction signal occurs in an interval between each pair of adjacent essentially 180° pulses in the pulse sequence, during the sequence of essentially 180° pulses superimposing upon the body a sequence of time-limited phase-encoding magnetic gradient fields and time-limited recording magnetic gradient fields, each phase-encoding magnetic gradient field being imposed during a time interval between a pair of adjacent essentially 180° pulses of the Carr-Purcell-Gill-Meiboom pulse sequence, a portion of the phase-encoding magnetic gradient field being imposed between the first essentially 180° pulse of the pair of pulses and a midpoint of the spin-echo nuclear induction signal occurring between the pair of pulses, each recording magnetic gradient field being imposed during the time interval between a pair of adjacent essentially 180° pulses of the Carr-Purcell-Gill-Meiboom pulse sequence coincident with the occurrence of the spin-echo nuclear induction signal between the pair of pulses, the phase-encoding magnetic gradient fields being changed after each essentially 180° pulse in accordance with a Fourier-transform tomographic imaging method, the form and timing of each time-limited magnetic gradient field relative to the substantially 180° pulses and the spin-echo nuclear induction signals being selected so that spin dephasing which arises during the magnetic gradient field is substantially cancelled at the end of the time-limited gradient field so that a spin phase condition at the time of each essentially 180° pulse subsequent to the first such pulse is substantially the same as a spin phase condition at the time of the preceding essentially 180° pulse, sampling and digitizing the spin-echo nuclear induction signals to form digitized nuclear signal data, and combining such digitized nuclear signal data in accordance with the Fourier-transform tomographic method to form a tomographic image of the cross section of the body.
Claim 3
Dependent Claim 30 words
Method according to claim 1, characterized by the body being excited repeatedly in succession with Carr-Purcell-Gill-Meiboom sequences and being subject to different phase-encoding magnetic gradient fields with the successive excitations.
Claim 4
Dependent Claim 53 words
Method according to claim 2, characterized by the time interval between the 90° pulse and the first 180° pulse as well as between the first two 180° pulses being increased with every excitation by a fraction of the constant interval between the remaining 180° pulses inversely proportionate to the planned number of repetitions.
Claim 5
Dependent Claim 27 words
Method according to claim 2, characterized by each repeated excitation occurring before a complete relaxation of the spin-moments excited by the preceding Carr-Purcell-Gill-Meiboom sequence has taken place.
Claim 6
Dependent Claim 33 words
Method according to claim 1 characterized by another phase-encoding magnetic gradient field being used as a selection magnetic gradient field and the image reconstruction occurring according to a three-dimensional nuclear-magnetic-resonance Fourier-transform tomographic method.

References Cited (Backward Citations)

EP0098426A2 Cited
US4521733A Cited
US4532474A Cited
US4595879A Cited
US4697148A Cited
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USPTO Annuity & Maintenance Windows

Annuity Stage Window Opens Payment Deadline Surcharge Period Until Estimated Fee Status
3.5 Years (Year 4) 1992-04-03 1992-10-03 1993-04-04 $2000.00 Window Closed / Lapsed
7.5 Years (Year 8) 1996-04-03 1996-10-03 1997-04-04 $3760.00 Window Closed / Lapsed
11.5 Years (Year 12) 2000-04-03 2000-10-03 2001-04-04 $7700.00 Window Closed / Lapsed

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