Patent US5285063A successfully refreshed from Google Patents.
US5285063A
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US
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Method of detecting ions in an ion trap mass spectrometer
Assignee: Thermo Finnigan LLC
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Filing: 1993-05-24
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Granted: 1994-02-08
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Expires: 2013-05-24
Abstract
Abstract A method is disclosed for operating an ion trap mass spectrometer in such a way as to distinguish resonantly ejected ions from non-resonantly ejected ions. A supplementary AC field is superimposed on the three-dimensional quadrupole trapping field and the combined fields are scanned to resonantly eject ions of consecutive mass-to-charge ratio. The ejected ions are detected and the output signal of the resonantly ejected ions has a frequency component at the frequency of the supplementary AC field.
Inventors
- 👤 Jae C. Schwartz
- 👤 John N. Louris
Bibliographic Details
Application Number
—
Jurisdiction
US
Data Source
google_patents
Last Synchronized
2026-11-08 18:08
CPC Classifications
H; H01; H01J; H01J49/00; H01J49/26; H01J49/34; H01J49/42; H01J49/4205; H01J49/424; H01J49/426; H01J49/427; H01J49/4285; H01J49/429
Claims Analysis
Total Claims: 24
Claim 1
Independent Claim
112 words
The method of operating an ion trap mass spectrometer comprising the steps of defining a trap volume with a three-dimensional substantially quadrupole field for trapping ions within a predetermined range of mass-to-charge ratio, forming within or injecting ions into said trap volume such that those within said predetermined mass-to-charge ratio range are trapped, applying a supplementary AC field superimposed on said three-dimensional quadrupole field to form combined fields, changing said combined fields to sequentially resonantly eject ions from said trap volume for detecting ejected ions and generating an output signal in which the output signal of said resonantly ejected ions has a frequency component at the frequency of said supplementary AC field.
Claim 2
Independent Claim
112 words
The method of operating an ion trap mass spectrometer comprising the steps of defining a trap volume with a three-dimensional substantially quadrupole field for trapping ions within a predetermined range of mass-to-charge ratio, forming within or injecting ions into said trap volume such that those within said predetermined mass-to-charge ratio range are trapped, applying a supplementary AC field superimposed on said three-dimensional quadrupole field to form combined fields, changing said combined fields to sequentially resonantly eject ions from said trap volume for detecting ejected ions and generating an output signal in which the output signal of said resonantly ejected ions has a frequency component at the frequency of said supplementary AC field.
Claim 3
Dependent Claim
28 words
The method as in claim 1 including the step of processing said signal to identify signal components having said frequency components to thereby identify said resonantly ejected ions.
Claim 4
Dependent Claim
20 words
The method as in claim 2 in which said step of processing includes amplifying the signal with a lock-in amplifier.
Claim 5
Dependent Claim
19 words
The method as in claim 2 in which said signal is digitally processed to identify the resonantly ejected ions.
Claim 6
Dependent Claim
23 words
The method as in claim 2 in which the signal is processed by multiplying by sin (f2πt+ρ) to identify the resonantly ejected ions.
Claim 7
Dependent Claim
34 words
The method as in claim 2 in which the signal is processed by calculating √((S(t)* sin (f*2πt+ρ)) 2 +(S(t)* cos (f*2πt+ρ) 2 ), where S(t) is the time at which each point is acquired.
Claim 8
Independent Claim
27 words
The method as in any one of claims 1, 2, 3, 4, 5 or 6 in which the processed signal is plotted to provide a mass spectrum.
Claim 9
Independent Claim
66 words
The method of operating an ion trap mass spectrometer in the mass selective instability mode with resonance ejection which comprises applying a supplementary AC field at a selected frequency, whereby the resonantly ejected ions have an ejection frequency component at said selected frequency, detecting the ejected ions and providing an output signal which includes a component having said selected frequency to identify said resonantly ejected ions.
Claim 10
Independent Claim
66 words
The method of operating an ion trap mass spectrometer in the mass selective instability mode with resonance ejection which comprises applying a supplementary AC field at a selected frequency, whereby the resonantly ejected ions have an ejection frequency component at said selected frequency, detecting the ejected ions and providing an output signal which includes a component having said selected frequency to identify said resonantly ejected ions.
Claim 11
Independent Claim
37 words
The method of operating an ion trap in the mass selective instability mode with resonant ejection of ions which comprises detecting all ejected ions including resontantly ejected and non-resonantly ejected ions, and identifying the resonantly ejected ions.
Claim 12
Independent Claim
37 words
The method of operating an ion trap in the mass selective instability mode with resonant ejection of ions which comprises detecting all ejected ions including resontantly ejected and non-resonantly ejected ions, and identifying the resonantly ejected ions.
Claim 13
Independent Claim
121 words
The method of operating an ion trap mass spectrometer comprising the steps of defining a trap volume with a three-dimensional substantially quadrupole field for trapping ions within a predetermined range of mass-to-charge ratio, forming within or injecting ions into said trap volume such that those within said predetermined mass-to-charge ratio range are trapped, applying at least two supplementary AC fields at different frequencies superimposed on said three-dimensional quadrupole field to form combined fields, changing said combined fields to sequentially resonantly eject ions from said trap volume for detecting ejected ions and generating an output signal in which the output signal of said resonantly ejected ions has a frequency component at the frequency of at least one of said supplementary AC fields.
Claim 14
Independent Claim
121 words
The method of operating an ion trap mass spectrometer comprising the steps of defining a trap volume with a three-dimensional substantially quadrupole field for trapping ions within a predetermined range of mass-to-charge ratio, forming within or injecting ions into said trap volume such that those within said predetermined mass-to-charge ratio range are trapped, applying at least two supplementary AC fields at different frequencies superimposed on said three-dimensional quadrupole field to form combined fields, changing said combined fields to sequentially resonantly eject ions from said trap volume for detecting ejected ions and generating an output signal in which the output signal of said resonantly ejected ions has a frequency component at the frequency of at least one of said supplementary AC fields.
Claim 15
Dependent Claim
28 words
The method as in claim 10 including the step of processing said signal to identify signal components having said frequency components to thereby identify said resonantly ejected ions.
Claim 16
Dependent Claim
20 words
The method as in claim 11 in which said step of processing includes amplifying the signal with a lock-in amplifier.
Claim 17
Dependent Claim
19 words
The method as in claim 11 in which said signal is digitally processed to identify the resonantly ejected ions.
Claim 18
Dependent Claim
23 words
The method as in claim 11 in which the signal is processed by multiplying by sin (f2πt+ρ) to identify the resonantly ejected ions.
Claim 19
Dependent Claim
34 words
The method as in claim 11 in which the signal is processed by calculating √((S(t)* sin (f*2πt+ρ)) 2 +(S(t)* cos (f*2πt+ρ) 2 ), where S(t) is the time at which each point is acquired.
Claim 20
Independent Claim
27 words
The method as in any one of claims 10, 11, 12, 13, 14 or 15 in which the processed signal is plotted to provide a mass spectrum.
Claim 21
Independent Claim
110 words
The method of operating an ion trap mass spectrometer comprising the steps of defining a trap volume with a field for trapping ions within a predetermined range of mass-to-charge ratio, forming or injecting ions within said trap volume such that those within said predetermined mass-to-charge ratio range are trapped, applying a supplementary AC field superimposed on said field to form combined fields, changing said combined fields to sequentially resonantly eject ions of consecutive mass-to-charge ratio from said trap volume for detecting ejected ions and providing an output signal in which the output signal of said resonantly ejected ions has a frequency component at the frequency of said supplementary AC field.
Claim 22
Independent Claim
110 words
The method of operating an ion trap mass spectrometer comprising the steps of defining a trap volume with a field for trapping ions within a predetermined range of mass-to-charge ratio, forming or injecting ions within said trap volume such that those within said predetermined mass-to-charge ratio range are trapped, applying a supplementary AC field superimposed on said field to form combined fields, changing said combined fields to sequentially resonantly eject ions of consecutive mass-to-charge ratio from said trap volume for detecting ejected ions and providing an output signal in which the output signal of said resonantly ejected ions has a frequency component at the frequency of said supplementary AC field.
Claim 23
Independent Claim
115 words
The method of operating an ion trap mass spectrometer comprising the steps of defining a trap volume with a field for trapping ions within a predetermined range of mass-to-charge ratio, forming or injecting ions within said trap volume such that those within said predetermined mass-to-charge ratio range are trapped, applying at least two supplementary AC fields at different frequencies superimposed on said field to form combined fields, changing said combined fields to sequentially resonantly eject ions of consecutive mass-to-charge ratio from said trap volume for detecting ejected ions and providing an output signal in which the output signal of said resonantly ejected ions has a frequency component at the frequency of said supplementary AC field.
Claim 24
Independent Claim
115 words
The method of operating an ion trap mass spectrometer comprising the steps of defining a trap volume with a field for trapping ions within a predetermined range of mass-to-charge ratio, forming or injecting ions within said trap volume such that those within said predetermined mass-to-charge ratio range are trapped, applying at least two supplementary AC fields at different frequencies superimposed on said field to form combined fields, changing said combined fields to sequentially resonantly eject ions of consecutive mass-to-charge ratio from said trap volume for detecting ejected ions and providing an output signal in which the output signal of said resonantly ejected ions has a frequency component at the frequency of said supplementary AC field.
References Cited (Backward Citations)
US4540884A
Cited
US5089703A
Cited
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