US5283342A
Expired / Lapsed
US
⏱️ 0.0 years remaining
Biotinylated small molecules
Assignee: Aletheon Pharmaceuticals Inc
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Filing: 1992-06-09
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Granted: 1994-02-01
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Expires: 2012-06-09
Abstract
Abstract Methods, compounds, compositions and kits that relate to pretargeted delivery of diagnostic and therapeutic agents are disclosed. In particular, methods for radiometal labeling of biotin and for improved radiohalogenation of biotin, as well as related compounds, are described.
Inventors
- 👤 Linda M. Gustavson
- 👤 Ananthachari Srinivasan
- 👤 Alan R. Fritzberg
- 👤 John M. Reno
- 👤 Donald B. Axworthy
Bibliographic Details
Application Number
—
Jurisdiction
US
Data Source
google_patents
Last Synchronized
2026-10-27 15:28
CPC Classifications
B; B82; B82Y; B82Y5/00; A; A61; A61K; A61K47/00; A61K47/50; A61K47/51; A61K47/68; A61K47/6891; A61K47/6893; A61K47/54; A61K47/555; A61K47/557; A61K47/62; A61K47/66; A61K47/665; A61K47/6835; A61K47/6887; A61K47/6897; A61K47/6898; A61K51/00; A61K51/02; A61K51/04; A61K51/0497; A61K51/12; A61K51/1268; A61K2121/00; A61K2123/00; Y; Y10; Y10S; Y10S436/00; Y10S436/804; Y10S436/807; Y10S436/808
Claims Analysis
Total Claims: 6
Claim 1
Independent Claim
41 words
A compound having a biotin portion and a chelate portion and having the following formula: ##STR16## wherein X is a spacer group which facilities steric availability of the biotin portion and R 1 is H or CH 2 CO 2 H.
Claim 2
Dependent Claim
41 words
A compound having a biotin portion and a chelate portion and having the following formula: ##STR16## wherein X is a spacer group which facilities steric availability of the biotin portion and R 1 is H or CH 2 CO 2 H.
Claim 3
Dependent Claim
22 words
The compound of claim 1 wherein X is (CH 2 ) n or CO(CH 2 ) 5 NH and n=0 to 5.
Claim 4
Dependent Claim
18 words
A compound of the following formula: ##STR17## wherein X is a radiohalogen and R is COOH or H.
Claim 5
Dependent Claim
18 words
A compound of the following formula: ##STR17## wherein X is a radiohalogen and R is COOH or H.
Claim 6
Dependent Claim
9 words
The compound of claim 3 wherein X is radioiodine.
References Cited (Backward Citations)
USPTO Annuity & Maintenance Windows
| Annuity Stage | Window Opens | Payment Deadline | Surcharge Period Until | Estimated Fee | Status |
|---|---|---|---|---|---|
| 3.5 Years (Year 4) | 1997-01-31 | 1997-08-02 | 1998-02-01 | $2000.00 | Window Closed / Lapsed |
| 7.5 Years (Year 8) | 2001-01-31 | 2001-08-02 | 2002-02-01 | $3760.00 | Window Closed / Lapsed |
| 11.5 Years (Year 12) | 2005-01-31 | 2005-08-02 | 2006-02-01 | $7700.00 | Window Closed / Lapsed |