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Patent US5283317A successfully refreshed from Google Patents.
US5283317A
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Intermediates for conjugation of polypeptides with high molecular weight polyalkylene glycols
Assignee: Sanofi SA
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Filing: 1991-10-11
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Granted: 1994-02-01
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Expires: 2011-10-11
Abstract
Abstract A biologically persistent, water-soluble, substantially non-immunogenic, substantially non-antigenic conjugate of superoxide dismutase is prepared by coupling one to five strands of a polyalkylene glycol which is polyethylene glycol or polyethylene-polypropylene glycol copolymer, wherein said polyalkylene glycol has an average molecular weight of about 35,000-1,000,000.
Inventors
- 👤 Mark Saifer
- 👤 Ralph Somack
- 👤 L. David Williams
Bibliographic Details
Application Number
—
Jurisdiction
US
Data Source
google_patents
Last Synchronized
2026-11-05 18:10
CPC Classifications
A; A61; A61K; A61K38/00; A61K38/16; A61K38/43; A61K38/44; A61K38/446; A61K47/00; A61K47/50; A61K47/51; A61K47/56; A61K47/59; A61K47/60; C; C12; C12N; C12N11/00; C12N11/02; C12N11/08; C12N11/089; C12N9/00; C12N9/96
Claims Analysis
Total Claims: 2
Claim 1
Independent Claim
60 words
A polyalkylene glycol which is a polyethylene glycol or polyethylene-polypropylene glycol copolymer wherein all of the polyalkylene glycol has an average molecular weight as determined by HPLC using PEG as standard of about 35,000-200,000 and is unsubstituted or substituted at one terminal by a C 1-4 alkyl group and substituted at another terminal by a group of the formula: ##STR2##
Claim 2
Dependent Claim
60 words
A polyalkylene glycol which is a polyethylene glycol or polyethylene-polypropylene glycol copolymer wherein all of the polyalkylene glycol has an average molecular weight as determined by HPLC using PEG as standard of about 35,000-200,000 and is unsubstituted or substituted at one terminal by a C 1-4 alkyl group and substituted at another terminal by a group of the formula: ##STR2##
References Cited (Backward Citations)
USPTO Annuity & Maintenance Windows
| Annuity Stage | Window Opens | Payment Deadline | Surcharge Period Until | Estimated Fee | Status |
|---|---|---|---|---|---|
| 3.5 Years (Year 4) | 1997-01-31 | 1997-08-02 | 1998-02-01 | $2000.00 | Window Closed / Lapsed |
| 7.5 Years (Year 8) | 2001-01-31 | 2001-08-02 | 2002-02-01 | $3760.00 | Window Closed / Lapsed |
| 11.5 Years (Year 12) | 2005-01-31 | 2005-08-02 | 2006-02-01 | $7700.00 | Window Closed / Lapsed |