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US5283058A
Expired / Lapsed
US
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Methods for inhibiting rejection of transplanted tissue
Assignee: General Hospital Corp
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Filing: 1991-03-19
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Granted: 1994-02-01
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Expires: 2011-03-19
Abstract
Abstract A method for inhibiting rejection by a recipient animal of a transplanted tissue, said method comprising modifying, eliminating, or masking an antigen which, when present on the surface of a cell of said tissue, is capable of causing a T-lymphocyte-mediated response in said animal, to inhibit antigen-mediated interaction between said cell and a T-lymphocyte of said animal without causing lysis of said cell.
Inventors
- 👤 Denise Faustman
Bibliographic Details
Application Number
—
Jurisdiction
US
Data Source
google_patents
Last Synchronized
2026-11-02 20:43
CPC Classifications
C; C12; C12N; C12N5/00; C12N5/06; C12N5/0602; C12N5/0676; A; A61; A61K; A61K35/00; A61K35/12; A61K35/22; A61K35/34; A61K35/37; A61K35/407; A61K35/42; A61P; A61P3/00; A61P3/08; A61P3/10; A61P37/00; A61P37/02; A61P37/06; C07; C07K; C07K16/00; C07K16/18; C07K16/28; C07K16/2803; C07K16/2833; A61K39/00; A61K2039/505; A61K38/00; C07K2317/00; C07K2317/50; C07K2317/54; C07K2317/70; Y; Y10; Y10S; Y10S424/00; Y10S424/809; Y10S424/81
Claims Analysis
Total Claims: 22
Claim 1
Independent Claim
80 words
A method for inhibiting rejection by a recipient animal of a human non-lymphoid tissue which is to be transplanted into a recipient animal, said method comprising modifying, eliminating, or masking an antigen of said non-lymphoid tissue which, when present on the surface of a cell of said human tissue, is capable of causing a T-lymphocyte-mediated response in the recipient animal, to inhibit antigen-mediated interaction between said cell and a T-lymphocyte of the recipient animal without causing lysis of said cell.
Claim 2
Independent Claim
80 words
A method for inhibiting rejection by a recipient animal of a human non-lymphoid tissue which is to be transplanted into a recipient animal, said method comprising modifying, eliminating, or masking an antigen of said non-lymphoid tissue which, when present on the surface of a cell of said human tissue, is capable of causing a T-lymphocyte-mediated response in the recipient animal, to inhibit antigen-mediated interaction between said cell and a T-lymphocyte of the recipient animal without causing lysis of said cell.
Claim 3
Independent Claim
86 words
A method for inhibiting rejection by a recipient animal of a non-lymphoid tissue obtained from an animal of a different species which is to be transplanted into the recipient animal, said method comprising modifying, eliminating, or masking an antigen of said non-lymphoid tissue which, when present on the surface of a cell of said tissue, is capable of causing a T-lymphocyte-mediated response in the recipient animal, to inhibit antigen-mediated interaction between said cell and a T-lymphocyte of the recipient animal without causing lysis of said cell.
Claim 4
Independent Claim
86 words
A method for inhibiting rejection by a recipient animal of a non-lymphoid tissue obtained from an animal of a different species which is to be transplanted into the recipient animal, said method comprising modifying, eliminating, or masking an antigen of said non-lymphoid tissue which, when present on the surface of a cell of said tissue, is capable of causing a T-lymphocyte-mediated response in the recipient animal, to inhibit antigen-mediated interaction between said cell and a T-lymphocyte of the recipient animal without causing lysis of said cell.
Claim 5
Dependent Claim
37 words
The method of claim 1 or claim 2 wherein said inhibiting comprises masking said antigen by treating said tissue with a non-lytic masking agent which is capable of forming a complex with said antigen on said cell.
Claim 6
Dependent Claim
17 words
The method of claim 1 or claim 2 wherein said inhibiting comprises modifying said antigen by capping.
Claim 7
Dependent Claim
15 words
The method of claim 1 or claim 2 wherein said cell is an islet cell.
Claim 8
Dependent Claim
11 words
The method of claim 1 wherein said animal is a human.
Claim 9
Dependent Claim
40 words
The method of claim 1 or claim 2 wherein said masking comprises treating said tissue with a non-lytic masking agent which comprises an antibody F(ab') 2 fragment which is capable of forming a complex with said antigen on said cell.
Claim 10
Dependent Claim
10 words
The method of claim 7 wherein said antibody is monoclonal.
Claim 11
Dependent Claim
15 words
The method of claim 7 wherein said antibody comprises a polyclonal antisera against said tissue.
Claim 12
Dependent Claim
39 words
The method of claim 3 wherein said antigen is an HLA class I antigen and a cytotoxic CD8+ lymphocyte of said animal is inhibited, by said masking agent, from interacting with said HLA class I antigen on said cell.
Claim 13
Dependent Claim
44 words
The method of claim 7 wherein said F(ab') 2 fragment is produced by digesting intact antibody and then purifying said fragment in a two-step process involving first applying the digested antibody to a Protein A column and then further purifying the fragment by HPLC.
Claim 14
Dependent Claim
13 words
The method of claim 3 wherein said antigen is a Class I antigen.
Claim 15
Dependent Claim
39 words
The method of claim 12 wherein said masking comprises treating said tissue with a non-lytic masking agent which comprises at least one antibody F(ab') 2 fragment which is capable of forming a complex with said antigen on said cell.
Claim 16
Dependent Claim
10 words
The method of claim 13 wherein said tissue is islets.
Claim 17
Dependent Claim
10 words
The method of claim 12 wherein said tissue is islets.
Claim 18
Dependent Claim
30 words
The method of claim 2 wherein said inhibiting comprises masking said antigen with a nonlytic masking agent which is capable of forming a complex with said antigen on said cell.
Claim 19
Dependent Claim
13 words
The method of claim 16 wherein said antigen is a Class I antigen.
Claim 20
Dependent Claim
39 words
The method of claim 17 wherein said masking comprises treating said tissue with a non-lytic masking agent which comprises at least one antibody F(ab') 2 fragment which is capable of forming a complex with said antigen on said cell.
Claim 21
Dependent Claim
13 words
The method of claim 1 wherein said antigen is a Class I antigen.
Claim 22
Dependent Claim
10 words
The method of claim 18 wherein said tissue is islets.
References Cited (Backward Citations)
WO1991006105A1
Cited
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