Devices and methods for optical diagnosis of tissue

Claim 2

An optical needle device for diagnosis of tissue comprising: an optically transparent needle have a coupling surface, a tapered surface and a cutting edge for insertion into tissue to be diagnosed such that a converging optical channel is provided where light entering through the coupling surface is internally reflected by the tapered surface and is increasingly divergent as it progresses along the convergent channel until the angle of incidence of the light against the tapered surface exceeds a critical angle and is directed onto tissue contacting the tapered surface; an optical fiber coupled to the coupling surface of the needle such that the light can be transmitted through the fiber into the needle and onto the contacted tissue to stimulate an emission of light by the tissue, the emitted light being transmitted through the needle and the optical fiber; and a light detector coupled to the optical fiber for receiving and detecting the light emission from the tissue.

Claim 3

The optical needle device of claim 1 wherein said needle further comprises a hypodermic needle having a distal opening and a lumen through which the optically transparent needle is positioned such that a plane formed by the distal surface lies in a plane formed by the distal opening.

Claim 4

The optical needle device of claim 1 further comprising a plurality of optical fibers that are optically coupled to the needle.

Claim 5

The optical needle device of claim 3 wherein the optical needle secures the fibers in a fixed spaced apart relationship.

Claim 6

The optical needle device of claim 1 wherein the detector comprises an analyzer that spectrally resolves the light emitted by the tissue.

Claim 7

The optical needle device of claim 5 wherein the analyzer comprises a spectrometer coupled to a distal end of the fiber to spectrally resolve the light emitted by the tissue.

Claim 8

The optical needle device of claim 1 wherein said optical needle comprises a groove projecting through a portion of the optically transparent needle such that a plurality of distal surfaces are formed defining the groove, each surface having a cutting edge for the incision of tissue.

Claim 9

The optical needle device of claim 7 wherein said groove comprises three distal surfaces such that tissue located within the channel is optically coupled to the three distal surfaces.

Claim 10

The optical needle device of claim 1 wherein said optical needle comprises a plurality of grooves projecting through a portion of the optically transparent needle.

Claim 11

The optical needle device of claim wherein the optically transparent needle comprises an optical fiber.

Claim 12

The optical needle device of claim wherein the optically transparent needle comprises an optical fiber bundle.

Claim 13

The optical needle device of claim 11 wherein a distal portion of the bundle is co red within a hypodermic needle.

Claim 14

The optical needle device of claim 11 wherein each fiber of the bundle has a distal surface which lies in a plane orthogonal to a longitudinal axis of the needle device.

Claim 15

The optical needle device of claim 11 wherein a distal end of each fiber of the bundle forms a single tapered distal surface.

Claim 16

The optical needle device of claim 1 further comprising a laser coupled to the optically transparent needle.

Claim 17

The optical needle device of claim 11 further comprising a channel having a plurality of distal surfaces wherein a selected number of fibers form each of the distal surfaces within the channel.

Claim 18

The optical needle device of claim 11 wherein one of said fibers couples a laser light source to the distal surface.

Claim 19

The optical needle device of claim 1 further comprising a source of laser radiation coupled to a distal end of the fiber to direct coherent radiation through the needle and into the tissue.

Claim 20

The optical needle device of claim 1 wherein the needle has a plurality of optical transmission surfaces through which light is directed onto tissue.

Claim 21

The optical needle device of claim 19 wherein the plurality of transmission surfaces comprises a first surface and a second surface such that light emitted through the first surface is directed through the tissue and onto the second surface.

Claim 22

An optical needle device for insertion and diagnose of tissue comprising an optically conductive needle having a cutting edge for the incision of tissue, a converging optical channel and a light transmitting distal surface that forms a groove extending along an exterior surface of the converging channel such that tissue cut by the edge is directed through the groove into optically conductive contact with the distal surface.

Claim 23

An optical needle device for insertion and diagnose of tissue comprising an optically conductive needle having a cutting edge for the incision of tissue, a converging optical channel and a light transmitting distal surface that forms a groove extending along an exterior surface of the converging channel such that tissue cut by the edge is directed through the groove into optically conductive contact with the distal surface.

Claim 24

The optical needle device of claim 21 wherein said plurality of distal surfaces further comprises a first tapered surface, a second surface extending orthogonal to the first surface, and a third surface parallel to the second surface such that the first, second and third surfaces form a groove that surrounds tissue extending into the groove on three sides.

Claim 25

The optical needle device of claim 22 wherein the first, second and third surfaces extend to a cutting edge at a distal tip of the needle.

Claim 26

The optical needle device of claim 21 further comprising a bundle of optical fibers coupled to a proximal end of the optical channel.

Claim 27

The optical needle device of claim 21 further comprising a plurality of converging channels, each channel extending along an optical fiber having a beveled distal surface.

Claim 28

The optical needle device of claim 25 further comprising a hypodermic needle through which the fibers extend.

Claim 29

The optical needle device of claim 21 further comprising a second groove extending along the exterior surface of the converging channel.

Claim 30

The optical needle device of claim 21 further comprising a laser coupled to the converging optical channel.

Claim 31

The optical needle devices of claim 21 further comprising a plurality of grooves extending along the convergent channel.

Claim 34

The method of claim 30 further comprising coupling a laser light source to the element to deliver radiation to the tissue to treat the tissue.

Claim 35

The method of claim 30 further comprising coupling the light source to the optically transparent element with an optic fiber.

Claim 36

The method of claim 3 further comprising coupling the optically transparent element to an analyzer with an optical fiber bundle.

Claim 37

The method of claim 3 further comprising inserting the needle into tissue such that the tissue is directed into a groove extending through the distal surface.

Claim 38

The method of claim 30 wherein the analyzing step comprises comparing a characteristic of the collected light with a reference.

Claim 39

The method of claim 30 rein the analyzing step further comprises coupling the collected light to a spectrometer.

Claim 40

The method of claim 3 wherein said optically transparent element comprises an optical fiber.

Claim 41

The method of claim 30 further comprising positioning the optically transparent element into a hypodermic needle such that the distal surface lies in a plane of a cutting angle on the needle.

Claim 42

The method of claim 3 wherein the optically transparent element comprises an optical fiber bundle.

Claim 43

The method of claim 38 wherein the optically transparent element comprises a plurality of grooves extending through the distal surface to receive the portion of tissue to be diagnosed.

Claim 44

A laser optical needle system for diagnosis of tissue comprising: a laser source provide radiation for delivery to the tissue to be diagnosed; an optically transparent needle having a coupling surface, a tapered surface and a cutting edge for insertion into tissue to be diagnosed such that a converging optical channel is provided where light entering through the coupling surface is internally reflected by the tapered surface and is increasingly divergent as it progresses along the convergent channel until the angle of incidence of the light against the tapered surface exceeds a critical angle and is directed onto tissue contacting the tapered surface; a plurality of optical fibers coupled at a distal end of each fiber to the coupling surface of the needle and at a proximal end of at least one of the fibers to the laser source such that laser radiation transmitted through the fibers into the needle and onto the contacted tissue to stimulate an emission of light by the tissue, the emitted light being transmitted through the needle and the optical fibers; and a spectral analyzer coupled to the proximal end of at least one of the optical fibers to receive the emitted light.

Claim 45

A laser optical needle system for diagnosis of tissue comprising: a laser source provide radiation for delivery to the tissue to be diagnosed; an optically transparent needle having a coupling surface, a tapered surface and a cutting edge for insertion into tissue to be diagnosed such that a converging optical channel is provided where light entering through the coupling surface is internally reflected by the tapered surface and is increasingly divergent as it progresses along the convergent channel until the angle of incidence of the light against the tapered surface exceeds a critical angle and is directed onto tissue contacting the tapered surface; a plurality of optical fibers coupled at a distal end of each fiber to the coupling surface of the needle and at a proximal end of at least one of the fibers to the laser source such that laser radiation transmitted through the fibers into the needle and onto the contacted tissue to stimulate an emission of light by the tissue, the emitted light being transmitted through the needle and the optical fibers; and a spectral analyzer coupled to the proximal end of at least one of the optical fibers to receive the emitted light.

Claim 46

The optical needle device of claim 41 wherein said needle further comprises a hypodermic needle having a distal opening and a lumen through which the optically transparent needle is positioned such that a plane formed by the distal surface lies in a plane formed by the distal opening.

Claim 47

The optical needle device of claim 42 further comprising a detector to detect the spectrally resolved light.

Claim 48

The optical needle device of claim 41 wherein said optical needle comprises a groove projecting through a portion of the optically transparent needle such that a plurality of distal surfaces are formed defining the groove, each surface having a cutting edge for the incision of tissue.

Claim 49

The optical needle device of claim 44 wherein said groove comprises three distal surfaces such that tissue located within the channel is optically coupled to the three distal surfaces.

Claim 50

The optical needle device of claim 41 wherein said optical needle comprises a plurality of grooves projecting through a portion of the optically transparent needle.

Claim 51

The optical needle device of claim 41 wherein the optically transparent needle comprises an optical fiber bundle.

Claim 52

The optical needle device of claim 47 wherein a distal portion of the bundle is configured within a hypodermic needle.

Claim 55

The method of claim 49 wherein the distal surface forms an optical needle having an edge for the incision of tissue.